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Science 29 January 1988:
Vol. 239. no. 4839, pp. 497 - 500
DOI: 10.1126/science.2448876
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Articles

Science, Vol 239, Issue 4839, 497-500
Copyright © 1988 by American Association for the Advancement of Science

articles

The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors

SM Goyert, E Ferrero, WJ Rettig, AK Yenamandra, F Obata, and MM Le Beau

Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.

CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.


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