Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 January 1988:
Vol. 239. no. 4838, pp. 401 - 404
DOI: 10.1126/science.3122324
Prev | Table of Contents | Next

Articles

Science, Vol 239, Issue 4838, 401-404
Copyright © 1988 by American Association for the Advancement of Science

articles

Suppression of macrophage activation and T-lymphocyte function in hypoprolactinemic mice

EW Bernton, MS Meltzer, and JW Holaday

Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307.

The effects of prolactin on lactation and reproductive organs are well known. However, the other possible target organs and physiological consequences of altered levels of circulating prolactin remain poorly understood. In this study, mice were treated with bromocryptine, a dopamine receptor agonist that inhibits pituitary prolactin secretion. Bromocryptine treatment prevented T-cell-dependent induction of macrophage tumoricidal activity after the intraperitoneal injection of Listeria monocytogenes or Mycobacterium bovis. Coincident treatment with ovine prolactin reversed this effect. Of the multiple events leading to macrophage activation in vivo, the production by T-lymphocytes of gamma-interferon was the most impaired in bromocryptine-treated mice. Lymphocyte proliferation after stimulation with mitogens in vitro was also depressed in spleens of bromocryptine-treated mice, and coadministration of prolactin also reversed this effect. Bromocryptine treatment also reduced the number of deaths resulting from inoculation of mice with Listeria; exogenous prolactin significantly reversed this effect. The critical influence of pituitary prolactin release on maintenance of lymphocyte function and on lymphokine-dependent macrophage activation suggests that, in mice, lymphocytes are an important target tissue for circulating prolactin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prolactin gene expression in mouse spleen helper T cells.
K Horiguchi, S Yagi, K Ono, Y Nishiura, M Tanaka, M Ishida, and T Harigaya (2004)
J. Endocrinol. 183, 639-646
   Abstract »    Full Text »    PDF »
Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives.
I. C. Chikanza and D. L. Kozaci (2004)
Rheumatology 43, 1337-1345
   Full Text »    PDF »
Is There Still a Place for Dopamine in the Modern Intensive Care Unit?.
Y. A. Debaveye and G. H. Van den Berghe (2004)
Anesth. Analg. 98, 461-468
   Abstract »    Full Text »    PDF »
Bad Medicine: Low-Dose Dopamine in the ICU.
C. L. Holmes and K. R. Walley (2003)
Chest 123, 1266-1275
   Abstract »    Full Text »    PDF »
Exercise increases prolactin-receptor expression on human lymphocytes.
K. Dohi, W. J. Kraemer, and A. M. Mastro (2003)
J Appl Physiol 94, 518-524
   Abstract »    Full Text »    PDF »
In polymyalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers.
R. H. Straub, J. Georgi, K. Helmke, P. Vaith, and B. Lang (2002)
Rheumatology 41, 423-429
   Abstract »    Full Text »    PDF »
Effect of prolactin on the antigen presenting function of monocyte-derived dendritic cells.
L Matera, M Mori, and A Galetto (2001)
Lupus 10, 728-734
   Abstract »    PDF »
Analysis of anti-prolactin autoantibodies in systemic lupus erythematosus.
F Blanco-Favela, K Chavez-Rueda, and A Leanos-Miranda (2001)
Lupus 10, 757-761
   Abstract »    PDF »
The Roles of Prolactin, Growth Hormone, Insulin-Like Growth Factor-I, and Thyroid Hormones in Lymphocyte Development and Function: Insights from Genetic Models of Hormone and Hormone Receptor Deficiency.
K. Dorshkind and N. D. Horseman (2000)
Endocr. Rev. 21, 292-312
   Abstract »    Full Text »
Influence of Prolactin on the Differentiation of Mouse B-Lymphoid Precursors.
P. Morales, M. V. Carretero, H. Geronimo, S. G. Copín, M. L. Gaspar, M. A. R. Marcos, and J. Martín-Pérez (1999)
Cell Growth Differ. 10, 583-590
   Abstract »    Full Text »
Immune System Development and Function in Prolactin Receptor-Deficient Mice.
B. Bouchard, C. J. Ormandy, J. P. Di Santo, and P. A. Kelly (1999)
J. Immunol. 163, 576-582
   Abstract »    Full Text »    PDF »
Prolactin, a pituitary hormone that modifies immune responses: Proceedings of the Mini-symposium on Prolactin and SLE, held at the 5th International Conference on Systemic Lupus Erythematosus, Cancun, Mexico.
S E Walker, D Miller, D L Hill, and G R Komatireddy (1998)
Lupus 7, 371-375
   PDF »
Bromocriptine in systemic lupus erythematosus: a double-blind, randomized, placebo-controlled study.
J Alvarez-Nemegyei, A Cobarrubias-Cobos, F Escalante-Triay, J Sosa-Muuoz, J M Miranda, and L J Jara (1998)
Lupus 7, 414-419
   Abstract »    PDF »
Differential effects of estrogen and prolactin on autoimmune disease in the NZB/NZW F1 mouse model of systemic lupus erythematosus.
K B Elbourne, D Keisler, and R W McMurray (1998)
Lupus 7, 420-427
   Abstract »    PDF »
Interleukin-1{beta} Enhances Interleukin-1 Receptor Antagonist Content in Human Somatotroph Adenoma Cell Cultures.
J. Sauer, U. Renner, U. Hopfner, M. Lange, A. Müller, C. J. Strasburger, U. Pagotto, E. Arzt, and G. K. Stalla (1998)
J. Clin. Endocrinol. Metab. 83, 2429-2434
   Abstract »    Full Text »
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice.
C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P. A. Kelly (1998)
Endocr. Rev. 19, 225-268
   Abstract »    Full Text »
Stoichiometric Structure-Function Analysis of the Prolactin Receptor Signaling Domain by Receptor Chimeras.
W.-P. Chang, Y. Ye, and C. V. Clevenger (1998)
Mol. Cell. Biol. 18, 896-905
   Abstract »    Full Text »    PDF »
A Bioactive 60-Kilodalton Prolactin Species Is Preferentially Secreted in Cultures of Mitogen-Stimulated and Nonstimulated Peripheral Blood Mononuclear Cells from Subjects with Systemic Lupus Erythematosus.
F. Larrea, A. Martinez-Castillo, V. Cabrera, J. Alcocer-Varela, G. Queipo, C. Carino, and D. Alarcon-Segovia (1997)
J. Clin. Endocrinol. Metab. 82, 3664-3669
   Abstract »    Full Text »    PDF »
Role of Bag-1 in the Survival and Proliferation of the Cytokine-Dependent Lymphocyte Lines, Ba/F3 and Nb2.
C. V. Clevenger, K. Thickman, W. Ngo, W.-P. Chang, S. Takayama, and J. C. Reed (1997)
Mol. Endocrinol. 11, 608-618
   Abstract »    Full Text »
Do Milk-Borne Cytokines and Hormones Influence Neonatal Immune Cell Function?.
L. A. Ellis, A. M. Mastro, and M. F. Picciano (1997)
J. Nutr. 127 , 985S
   Abstract »    Full Text »    PDF »
Low Concentrations of Ethanol Inhibits Prolactin-Induced Mitogenesis and Cytokine Expression in Cultured Astrocytes.
W. J. DeVito, S. Stone, and K. Mori (1997)
Endocrinology 138, 922-928
   Abstract »    Full Text »    PDF »
Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line.
C. V. Clevenger, W. Ngo, D. L. Sokol, S. M. Luger, and , A. M. Gewirtz (1995)
J. Biol. Chem. 270, 13246-13253
   Abstract »    Full Text »    PDF »
Photoperiodic Effects on Tumor Development and Immune Function.
R. J. Nelson and J. M. C. Blom (1994)
J Biol Rhythms 9, 233-249
   Abstract »    PDF »
The Hypothalamic-Pituitary-Adrenal--Immune Axis: A Critical Assessment.
M. P. Lilly and D. S. Gann (1992)
Arch Surg 127, 1463-1474
   Abstract »    PDF »
Requirement of nuclear prolactin for interleukin-2--stimulated proliferation of T lymphocytes.
C. Clevenger, S. Altmann, and M. Prystowsky (1991)
Science 253, 77-79
   Abstract »    PDF »
Role of Arginine in Trauma, Sepsis, and Immunity.
S. J. Kirk and A. Barbul (1990)
JPEN J Parenter Enteral Nutr 14, 226S-229S
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)