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Science 15 January 1988: Vol. 239. no. 4837, pp. 290 - 292 DOI: 10.1126/science.3276004
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Articles
Science, Vol 239, Issue 4837, 290-292
Copyright © 1988 by American Association for the Advancement of Science
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
WF Hickey
and
H Kimura
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6079.
A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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172, 6587-6597
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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172, 5707-5713
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| PDF »
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- W.-K. Kim, S. Corey, X. Alvarez, and K. Williams (2003)
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74, 650-656
| Abstract »
| Full Text »
| PDF »
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- A. Monsonego and H. L. Weiner (2003)
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| Abstract »
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| PDF »
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- D. Zenker, D. Begley, H. Bratzke, H. Rubsamen-Waigmann, and H. von Briesen (2003)
J. Physiol.
551, 1023-1032
| Abstract »
| Full Text »
| PDF »
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- A. Monsonego, J. Imitola, V. Zota, T. Oida, and H. L. Weiner (2003)
J. Immunol.
171, 2216-2224
| Abstract »
| Full Text »
| PDF »
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- D. S. Gregerson and J. Yang (2003)
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| Abstract »
| Full Text »
| PDF »
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170, 5281-5294
| Abstract »
| Full Text »
| PDF »
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- E. H. Hughes, F. C. Schlichtenbrede, C. C. Murphy, G.-M. Sarra, P. J. Luthert, R. R. Ali, and A. D. Dick (2003)
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44, 2229-2234
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| PDF »
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- J. M. Weimann, C. A. Charlton, T. R. Brazelton, R. C. Hackman, and H. M. Blau (2003)
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100, 2088-2093
| Abstract »
| Full Text »
| PDF »
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- G. R. John, S. C. Lee, and C. F. Brosnan (2003)
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9, 10-22
| Abstract »
| PDF »
- Nonmyelin-Specific T Cells Accelerate Development of Central Nervous System APC and Increase Susceptibility to Experimental Autoimmune Encephalomyelitis.
- R. E. Jones, T. Kay, T. Keller, and D. Bourdette (2003)
J. Immunol.
170, 831-837
| Abstract »
| Full Text »
| PDF »
- Pathogenic Role of Retinal Microglia in Experimental Uveoretinitis.
- N. A. Rao, T. Kimoto, E. Zamir, R. Giri, R. Wang, S. Ito, G. Pararajasegaram, R. W. Read, and G.-S. Wu (2003)
Invest. Ophthalmol. Vis. Sci.
44, 22-31
| Abstract »
| Full Text »
| PDF »
- Effect of endothelial cell polarity on beta -amyloid-induced migration of monocytes across normal and AD endothelium.
- R. Giri, S. Selvaraj, C. A. Miller, F. Hofman, S. D. Yan, D. Stern, B. V. Zlokovic, and V. K. Kalra (2002)
Am J Physiol Cell Physiol
283, C895-C904
| Abstract »
| Full Text »
| PDF »
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- F. Re, S. L. Belyanskaya, R. J. Riese, B. Cipriani, F. R. Fischer, F. Granucci, P. Ricciardi-Castagnoli, C. Brosnan, L. J. Stern, J. L. Strominger, et al. (2002)
J. Immunol.
169, 2264-2273
| Abstract »
| Full Text »
| PDF »
- Proliferating Cellular Nuclear Antigen Expression as a Marker of Perivascular Macrophages in Simian Immunodeficiency Virus Encephalitis.
- K. Williams, A. Schwartz, S. Corey, M. Orandle, W. Kennedy, B. Thompson, X. Alvarez, C. Brown, S. Gartner, and A. Lackner (2002)
Am. J. Pathol.
161, 575-585
| Abstract »
| Full Text »
| PDF »
- Intrathecal Fas Ligand Infusion Strengthens Immunoprivilege of Central Nervous System and Suppresses Experimental Autoimmune Encephalomyelitis.
- B. Zhu, L. Luo, Y. Chen, D. W. Paty, and M. S. Cynader (2002)
J. Immunol.
169, 1561-1569
| Abstract »
| Full Text »
| PDF »
- Distinct Brain Vascular Cell Types Manifest Inducible Cyclooxygenase Expression as a Function of the Strength and Nature of Immune Insults.
- J. C. Schiltz and P. E. Sawchenko (2002)
J. Neurosci.
22, 5606-5618
| Abstract »
| Full Text »
| PDF »
- Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma.
- P. G. Stevenson, J. M. Austyn, and S. Hawke (2002)
J. Gen. Virol.
83, 1735-1743
| Abstract »
| Full Text »
| PDF »
- Differentiation plasticity of hematopoietic cells.
- T. Graf (2002)
Blood
99, 3089-3101
| Full Text »
| PDF »
- De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis.
- S. M. Tompkins, J. Padilla, M. C. Dal Canto, J. P.-Y. Ting, L. Van Kaer, and S. D. Miller (2002)
J. Immunol.
168, 4173-4183
| Abstract »
| Full Text »
| PDF »
- The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS.
- S. Lehnardt, C. Lachance, S. Patrizi, S. Lefebvre, P. L. Follett, F. E. Jensen, P. A. Rosenberg, J. J. Volpe, and T. Vartanian (2002)
J. Neurosci.
22, 2478-2486
| Abstract »
| Full Text »
| PDF »
- Involvement of Cathepsin E in Exogenous Antigen Processing in Primary Cultured Murine Microglia.
- T. Nishioku, K. Hashimoto, K. Yamashita, S.-Y. Liou, Y. Kagamiishi, H. Maegawa, N. Katsube, C. Peters, K. von Figura, P. Saftig, et al. (2002)
J. Biol. Chem.
277, 4816-4822
| Abstract »
| Full Text »
| PDF »
- CD40-CD40L Interactions Induce Chemokine Expression by Human Microglia : Implications for Human Immunodeficiency Virus Encephalitis and Multiple Sclerosis.
- T. G. D'Aversa, K. M. Weidenheim, and J. W. Berman (2002)
Am. J. Pathol.
160, 559-567
| Abstract »
| Full Text »
| PDF »
- Light-Induced Migration of Retinal Microglia into the Subretinal Space.
- T. F. Ng and J. W. Streilein (2001)
Invest. Ophthalmol. Vis. Sci.
42, 3301-3310
| Abstract »
| Full Text »
| PDF »
- Rapid Response of Identified Resident Endoneurial Macrophages to Nerve Injury.
- M. Mueller, K. Wacker, E. B. Ringelstein, W. F. Hickey, Y. Imai, and R. Kiefer (2001)
Am. J. Pathol.
159, 2187-2197
| Abstract »
| Full Text »
| PDF »
- Developmental plasticity of CNS microglia.
- L. Santambrogio, S. L. Belyanskaya, F. R. Fischer, B. Cipriani, C. F. Brosnan, P. Ricciardi-Castagnoli, L. J. Stern, J. L. Strominger, and R. Riese (2001)
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98, 6295-6300
| Abstract »
| Full Text »
| PDF »
- Perivascular Macrophages Are the Primary Cell Type Productively Infected by Simian Immunodeficiency Virus in the Brains of Macaques: Implications for the Neuropathogenesis of AIDS.
- K. C. Williams, S. Corey, S. V. Westmoreland, D. Pauley, H. Knight, C. deBakker, X. Alvarez, and A. A. Lackner (2001)
J. Exp. Med.
193, 905-916
| Abstract »
| Full Text »
| PDF »
- The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System.
- B. Becher, B. G. Durell, A. V. Miga, W. F. Hickey, and R. J. Noelle (2001)
J. Exp. Med.
193, 967-974
| Abstract »
| Full Text »
| PDF »
- Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation.
- H.-G. Fischer and G. Reichmann (2001)
J. Immunol.
166, 2717-2726
| Abstract »
| Full Text »
| PDF »
- T Lymphocytes Promote the Development of Bone Marrow-Derived APC in the Central Nervous System.
- S. Subramanian, D. N. Bourdette, C. Corless, A. A. Vandenbark, H. Offner, and R. E. Jones (2001)
J. Immunol.
166, 370-376
| Abstract »
| Full Text »
| PDF »
- beta -Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.
- R. Giri, Y. Shen, M. Stins, S. Du Yan, A. M. Schmidt, D. Stern, K.-S. Kim, B. Zlokovic, and V. K. Kalra (2000)
Am J Physiol Cell Physiol
279, C1772-C1781
| Abstract »
| Full Text »
| PDF »
- Intracerebral Recruitment and Maturation of Dendritic Cells in the Onset and Progression of Experimental Autoimmune Encephalomyelitis.
- B. Serafini, S. Columba-Cabezas, F. Di Rosa, and F. Aloisi (2000)
Am. J. Pathol.
157, 1991-2002
| Abstract »
| Full Text »
| PDF »
- Temporal Development of Autoreactive Th1 Responses and Endogenous Presentation of Self Myelin Epitopes by Central Nervous System-Resident APCs in Theiler's Virus-Infected Mice.
- Y. Katz-Levy, K. L. Neville, J. Padilla, S. Rahbe, W. S. Begolka, A. M. Girvin, J. K. Olson, C. L. Vanderlugt, and S. D. Miller (2000)
J. Immunol.
165, 5304-5314
| Abstract »
| Full Text »
| PDF »
- The Brain Parenchyma Is Permissive for Full Antitumor CTL Effector Function, Even in the Absence of CD4 T Cells.
- P. R. Walker, T. Calzascia, V. Schnuriger, N. Scamuffa, P. Saas, N. de Tribolet, and P.-Y. Dietrich (2000)
J. Immunol.
165, 3128-3135
| Abstract »
| Full Text »
| PDF »
- IFN-{gamma} and LPS-Mediated IL-10-Dependent Suppression of Retinal Microglial Activation.
- C. Broderick, L. Duncan, N. Taylor, and A. D. Dick (2000)
Invest. Ophthalmol. Vis. Sci.
41, 2613-2622
| Abstract »
| Full Text »
- Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment.
- M. D. Carrithers, I. Visintin, S. J. Kang, and C. A. Janeway Jr (2000)
Brain
123, 1092-1101
| Abstract »
| Full Text »
| PDF »
- Phenotype and Functions of Brain Dendritic Cells Emerging During Chronic Infection of Mice with Toxoplasma gondii.
- H.-G. Fischer, U. Bonifas, and G. Reichmann (2000)
J. Immunol.
164, 4826-4834
| Abstract »
| Full Text »
| PDF »
- Presentation of {alpha}B-Crystallin to T Cells in Active Multiple Sclerosis Lesions: An Early Event Following Inflammatory Demyelination.
- J. J. Bajramovic, A. C. Plomp, A. v. d. Goes, C. Koevoets, J. Newcombe, M. L. Cuzner, and J. M. van Noort (2000)
J. Immunol.
164, 4359-4366
| Abstract »
| Full Text »
| PDF »
- Retinal Microglia Differentially Express Phenotypic Markers of Antigen-Presenting Cells In Vitro.
- T. Matsubara, G. Pararajasegaram, G.-S. Wu, and N. A. Rao (1999)
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40, 3186-3193
| Abstract »
| Full Text »
| PDF »
- Depletion of Blood-Borne Macrophages Does Not Reduce Demyelination in Mice Infected with a Neurotropic Coronavirus.
- S. Xue, N. Sun, N. Van Rooijen, and S. Perlman (1999)
J. Virol.
73, 6327-6334
| Abstract »
| Full Text »
- Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production.
- J. M. Soos, T. A. Ashley, J. Morrow, J. C. Patarroyo, B. E. Szente, and S. S. Zamvil (1999)
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11, 1169-1179
| Abstract »
| Full Text »
| PDF »
- Microglia in Alzheimer's Disease and Transgenic Models : How Close the Fit?.
- D. W. Dickson (1999)
Am. J. Pathol.
154, 1627-1631
| Full Text »
| PDF »
- T Cell Immunity Induced by Allogeneic Microglia in Relation to Neuronal Retina Transplantation.
- N. Ma and J. W. Streilein (1999)
J. Immunol.
162, 4482-4489
| Abstract »
| Full Text »
| PDF »
- Disproportionate Recruitment of CD8+ T Cells into the Central Nervous System by Professional Antigen-Presenting Cells.
- M. J. Carson, C. R. Reilly, J. G. Sutcliffe, and D. Lo (1999)
Am. J. Pathol.
154, 481-494
| Abstract »
| Full Text »
| PDF »
- Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin A under control of the colony-stimulating factor-1 receptor promoter.
- C. N. Hahn, M. del Pilar Martin, X.-Y. Zhou, L. W. Mann, and A. d'Azzo (1998)
PNAS
95, 14880-14885
| Abstract »
| Full Text »
| PDF »
- Astrocytes Express Elements of the Class II Endocytic Pathway and Process Central Nervous System Autoantigen for Presentation to Encephalitogenic T Cells.
- J. M. Soos, J. Morrow, T. A. Ashley, B. E. Szente, E. K. Bikoff, and S. S. Zamvil (1998)
J. Immunol.
161, 5959-5966
| Abstract »
| Full Text »
| PDF »
- Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler's Murine Encephalomyelitis Virus.
- J. G. Pope, C. L. Vanderlugt, S. M. Rahbe, H. L. Lipton, and S. D. Miller (1998)
J. Virol.
72, 7762-7771
| Abstract »
| Full Text »
| PDF »
- Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice.
- E. H. Tran, K. Hoekstra, N. van Rooijen, C. D. Dijkstra, and T. Owens (1998)
J. Immunol.
161, 3767-3775
| Abstract »
| Full Text »
| PDF »
- T-Cell Apoptosis in Inflammatory Brain Lesions : Destruction of T Cells Does Not Depend on Antigen Recognition.
- J. Bauer, M. Bradl, W. F. Hickey, S. Forss-Petter, H. Breitschopf, C. Linington, H. Wekerle, and H. Lassmann (1998)
Am. J. Pathol.
153, 715-724
| Abstract »
| Full Text »
| PDF »
- Characterization of a Novel Bax-Associated Protein Expressed in Hemopoietic Tissues and Regulated During Thymocyte Apoptosis.
- H. He, P. A. Hershberger, and S. A. McCarthy (1998)
J. Immunol.
161, 1169-1175
| Abstract »
| Full Text »
| PDF »
- Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-{gamma}-Activated SJL/J Astrocytes.
- L. Tan, K. B. Gordon, J. P. Mueller, L. A. Matis, and S. D. Miller (1998)
J. Immunol.
160, 4271-4279
| Abstract »
| Full Text »
| PDF »
- Stem cells transplantation-a cure for autoimmune diseases.
- Y Sherer and Y Shoenfeld (1998)
Lupus
7, 137-140
| PDF »
- Cytokine Induction of MIP-1{alpha} and MIP-1{beta} in Human Fetal Microglia.
- C. M. McManus, C. F. Brosnan, and J. W. Berman (1998)
J. Immunol.
160, 1449-1455
| Abstract »
| Full Text »
| PDF »
- Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting.
- H. Korner, D. S. Riminton, D. H. Strickland, F. A. Lemckert, J. D. Pollard, and J. D. Sedgwick (1997)
J. Exp. Med.
186, 1585-1590
| Abstract »
| Full Text »
| PDF »
- Kinetics of Central Nervous System Microglial and Macrophage Engraftment: Analysis Using a Transgenic Bone Marrow Transplantation Model.
- D. W. Kennedy and J. L. Abkowitz (1997)
Blood
90, 986-993
| Abstract »
| Full Text »
| PDF »
- Neurons Promote Macrophage Proliferation by Producing Transforming Growth Factor-beta 2.
- A. Dobbertin, P. Schmid, M. Gelman, J. Glowinski, and M. Mallat (1997)
J. Neurosci.
17, 5305-5315
| Abstract »
| Full Text »
| PDF »
- Bone Marrow Transplantation in Acid Sphingomyelinase-Deficient Mice: Engraftment and Cell Migration Into the Brain as a Function of Radiation, Age, and Phenotype.
- S. R.P. Miranda, S. Erlich, J. W.M. Visser, S. Gatt, A. Dagan, V. L. Friedrich Jr, and E. H. Schuchman (1997)
Blood
90, 444-452
| Abstract »
| Full Text »
| PDF »
- Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages.
- S. Fazio, V. R. Babaev, A. B. Murray, A. H. Hasty, K. J. Carter, L. A. Gleaves, J. B. Atkinson, and M. F. Linton (1997)
PNAS
94, 4647-4652
| Abstract »
| Full Text »
| PDF »
- Major Histocompatibility Class II Molecules in the CNS: Increased Microglial Expression at the Onset of Narcolepsy in a Canine Model.
- M. Tafti, S. Nishino, M. S. Aldrich, W. Liao, W. C. Dement, and E. Mignot (1996)
J. Neurosci.
16, 4588-4595
| Abstract »
| Full Text »
| PDF »
- Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells..
- X Y Zhou, H Morreau, R Rottier, D Davis, E Bonten, N Gillemans, D Wenger, F G Grosveld, P Doherty, and K Suzuki (1995)
Genes & Dev.
9, 2623-2634
| Abstract »
| PDF »
- Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.
- M. Linton, J. Atkinson, and S Fazio (1995)
Science
267, 1034-1037
| Abstract »
| PDF »
- Case 40-1993- A 61-Year-Old Woman with Jaundice, Anemia, Thrombocytopenia, and Leukocytosis.
- D. W. Golde and D. Rubin (1993)
N. Engl. J. Med.
329, 1108-1115
| Full Text »
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