Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 December 1987:
Vol. 238. no. 4834, pp. 1717 - 1720
DOI: 10.1126/science.2825356
Prev | Table of Contents | Next

Articles

Science, Vol 238, Issue 4834, 1717-1720
Copyright © 1987 by American Association for the Advancement of Science

articles

A novel putative tyrosine kinase receptor encoded by the eph gene

H Hirai, Y Maru, K Hagiwara, J Nishida, and F Takaku

Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

Growth factors and their receptors are involved in the regulation of cell proliferation and also play a key role in oncogenesis. In this study, a novel putative kinase receptor gene, termed eph, has been identified and characterized by molecular cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and includes a cysteine-rich region in the extracellular domain. However, other features of the sequence distinguish the eph gene product from known receptors with tyrosine kinase activity. Thus the eph protein may define a new class of these molecules. The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
T. Yamazaki, J. Masuda, T. Omori, R. Usui, H. Akiyama, and Y. Maru (2009)
J. Cell Sci. 122, 243-255
   Abstract »    Full Text »    PDF »
The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting.
J. Wykosky and W. Debinski (2008)
Mol. Cancer Res. 6, 1795-1806
   Abstract »    Full Text »    PDF »
Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1.
E. V. Bocharov, M. L. Mayzel, P. E. Volynsky, M. V. Goncharuk, Y. S. Ermolyuk, A. A. Schulga, E. O. Artemenko, R. G. Efremov, and A. S. Arseniev (2008)
J. Biol. Chem. 283, 29385-29395
   Abstract »    Full Text »    PDF »
Fibronectin Type I Repeat Is a Nonactivating Ligand for EphA1 and Inhibits ATF3-dependent Angiogenesis.
J. Masuda, R. Usui, and Y. Maru (2008)
J. Biol. Chem. 283, 13148-13155
   Abstract »    Full Text »    PDF »
Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?.
M. Lackmann and A. W. Boyd (2008)
Science Signaling 1, re2
   Abstract »    Full Text »    PDF »
Eph/ephrin signaling: networks.
D. Arvanitis and A. Davy (2008)
Genes & Dev. 22, 416-429
   Abstract »    Full Text »    PDF »
Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers.
S. Alam, J Fujimoto, I Jahan, E Sato, and T Tamaya (2007)
Ann. Onc. 18, 485-490
   Abstract »    Full Text »    PDF »
Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking.
D. Pfaff, U. Fiedler, and H. G. Augustin (2006)
J. Leukoc. Biol. 80, 719-726
   Abstract »    Full Text »    PDF »
Disruption of EphA2 Receptor Tyrosine Kinase Leads to Increased Susceptibility to Carcinogenesis in Mouse Skin..
H. Guo, H. Miao, L. Gerber, J. Singh, M. F. Denning, A. C. Gilliam, and B. Wang (2006)
Cancer Res. 66, 7050-7058
   Abstract »    Full Text »    PDF »
Ephrin-A1 expression contributes to the malignant characteristics of {alpha}-fetoprotein producing hepatocellular carcinoma.
H Iida, M Honda, H F Kawai, T Yamashita, Y Shirota, B-C Wang, H Miao, and S Kaneko (2005)
Gut 54, 843-851
   Abstract »    Full Text »    PDF »
EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma.
P. H. Thaker, M. Deavers, J. Celestino, A. Thornton, M. S. Fletcher, C. N. Landen, M. S. Kinch, P. A. Kiener, and A. K. Sood (2004)
Clin. Cancer Res. 10, 5145-5150
   Abstract »    Full Text »    PDF »
Identification of Tyrosine Kinases Overexpressed in Head and Neck Cancer.
H.-S. Lin, G. J. Berry, W. E. Fee Jr, D. J. Terris, and Z. Sun (2004)
Arch Otolaryngol Head Neck Surg 130, 311-316
   Abstract »    Full Text »    PDF »
Identification and Characterization of Two Splice Variants of Human Diacylglycerol Kinase {eta}.
T. Murakami, F. Sakane, S.-i. Imai, K. Houkin, and H. Kanoh (2003)
J. Biol. Chem. 278, 34364-34372
   Abstract »    Full Text »    PDF »
Increased Messenger RNA for Allograft Inflammatory Factor-1, LERK-5, and a Novel Gene in 17.5-Day Relative to 15.5-Day Bovine Embryos.
M. D. Glover and G. E. Seidel Jr (2003)
Biol Reprod 69, 1002-1012
   Abstract »    Full Text »    PDF »
`Eph'ective signaling: forward, reverse and crosstalk.
K. K. Murai and E. B. Pasquale (2003)
J. Cell Sci. 116, 2823-2832
   Abstract »    Full Text »    PDF »
Human Endometrial Epithelial Cells Express Ephrin A1: Possible Interaction between Human Blastocysts and Endometrium via Eph-Ephrin System.
H. Fujiwara, S. Yoshioka, K. Tatsumi, K. Kosaka, Y. Satoh, Y. Nishioka, M. Egawa, T. Higuchi, and S. Fujii (2002)
J. Clin. Endocrinol. Metab. 87, 5801-5807
   Abstract »    Full Text »    PDF »
Phorbol Ester-regulated Oligomerization of Diacylglycerol Kinase delta Linked to Its Phosphorylation and Translocation.
S.-i. Imai, F. Sakane, and H. Kanoh (2002)
J. Biol. Chem. 277, 35323-35332
   Abstract »    Full Text »    PDF »
Differential effects of overexpression of two forms of ephrin-A5 on neonatal rat cardiomyocytes.
Y. Y. Li, Z. Mi, Y. Feng, C. F. McTiernan, R. Zhou, P. D. Robbins, S. C. Watkins, and A. M. Feldman (2001)
Am J Physiol Heart Circ Physiol 281, H2738-H2746
   Abstract »    Full Text »    PDF »
Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II Molecules.
R. Chiari, G. Hames, V. Stroobant, C. Texier, B. Maillère, T. Boon, and P. G. Coulie (2000)
Cancer Res. 60, 4855-4863
   Abstract »    Full Text »
Expression of Eph receptors and ephrins is differentially regulated by E-cadherin.
S Orsulic and R Kemler (2000)
J. Cell Sci. 113, 1793-1802
   Abstract »    PDF »
Characterization of the Shank Family of Synaptic Proteins. MULTIPLE GENES, ALTERNATIVE SPLICING, AND DIFFERENTIAL EXPRESSION IN BRAIN AND DEVELOPMENT.
S. Lim, S. Naisbitt, J. Yoon, J.-I. Hwang, P.-G. Suh, M. Sheng, and E. Kim (1999)
J. Biol. Chem. 274, 29510-29518
   Abstract »    Full Text »    PDF »
Oligomeric Structure of the Human EphB2 Receptor SAM Domain.
C. D. Thanos, K. E. Goodwill, and J. U. Bowie (1999)
Science 283, 833-836
   Abstract »    Full Text »
Eph receptors and ephrins: effectors of morphogenesis.
N Holder and R Klein (1999)
Development 126, 2033-2044
   Abstract »    PDF »
Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand.
T. L. Jones, L. D. Chong, J. Kim, R.-H. Xu, H.-F. Kung, and I. O. Daar (1998)
PNAS 95, 576-581
   Abstract »    Full Text »    PDF »
Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis.
Z Nikolova, V Djonov, G Zuercher, A. Andres, and A Ziemiecki (1998)
J. Cell Sci. 111, 2741-2751
   Abstract »    PDF »
IL-1beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes.
Y. Y. Li, C. F. McTiernan, and A. M. Feldman (1998)
Am J Physiol Heart Circ Physiol 274, H331-H341
   Abstract »    Full Text »    PDF »
Ligand for EPH-related Kinase (LERK) 7 Is the Preferred High Affinity Ligand for the HEK Receptor.
M. Lackmann, R. J. Mann, L. Kravets, F. M. Smith, T. A. Bucci, K. F. Maxwell, G. J. Howlett, J. E. Olsson, T. Vanden Bos, D. P. Cerretti, et al. (1997)
J. Biol. Chem. 272, 16521-16530
   Abstract »    Full Text »    PDF »
Cell-Cell Adhesion Mediated by Binding of Membrane-anchored Ligand LERK-2 to the EPH-related Receptor Human Embryonal Kinase 2Promotes Tyrosine Kinase Activity.
B. Bohme, T. VandenBos, D. P. Cerretti, L. S. Park, U. Holtrich, H. Rubsamen-Waigmann, and K. Strebhardt (1996)
J. Biol. Chem. 271, 24747-24752
   Abstract »    Full Text »    PDF »
Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases.
F. Sakane, S.-i. Imai, M. Kai, I. Wada, and H. Kanoh (1996)
J. Biol. Chem. 271, 8394-8401
   Abstract »    Full Text »    PDF »
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
S Davis, N. Gale, T. Aldrich, P. Maisonpierre, V Lhotak, T Pawson, M Goldfarb, and G. Yancopoulos (1994)
Science 266, 816-819
   Abstract »    PDF »
Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish.
Q Xu, N Holder, R Patient, and S. Wilson (1994)
Development 120, 287-299
   Abstract »    PDF »
Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage.
H. Schnurch and W. Risau (1993)
Development 119, 957-968
   Abstract »    PDF »
Receptor Protein Tyrosine Kinases and Phosphatases.
T. Hunter, R.A. Lindberg, D.S. Middlemas, S. Tracy, and P. van der Geer (1992)
Cold Spring Harb Symp Quant Biol 57, 25-41
   Abstract »    PDF »
Growth factors and cancer.
S. Aaronson (1991)
Science 254, 1146-1153
   Abstract »    PDF »
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
S. Hanks, A. Quinn, and T Hunter (1988)
Science 241, 42-52
   Abstract »    PDF »
Targets for Signal-transducing Protein Kinases.
T. Hunter, P. Angel, W.J. Boyle, R. Chiu, E. Freed, K.L. Gould, C.M. Isacke, M. Karin, R.A. Lindberg, and P. van der Geer (1988)
Cold Spring Harb Symp Quant Biol 53, 131-142
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)