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Science 11 December 1987:
Vol. 238. no. 4833, pp. 1581 - 1583
DOI: 10.1126/science.2825353
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Articles

Science, Vol 238, Issue 4833, 1581-1583
Copyright © 1987 by American Association for the Advancement of Science

articles

HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia

V Manzari, A Gismondi, G Barillari, S Morrone, A Modesti, L Albonici, L De Marchis, V Fazio, A Gradilone, M Zani, and al. et

Dipartimento di Medicina Sperimentale e Scienze Biochimiche II, Universita di Roma, Tor Vergata, Italy.

A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Detection of Human T-Cell Lymphotrophic Virus Type I in Archival Tissue Specimens.
G. S. Wood, A. Ruffo, A. Salvekar, W. Henghold, M. Takeshita, and M. Kikuchi (1996)
Arch Dermatol 132, 1339-1343
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Mikulas Popovic's Letter on The HIV-1/HTLV-IIIB/83 Isolate and the Pooling Experiment.
(1991)
Science 253, 730
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Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides.
W. Hall, C. Liu, O Schneewind, H Takahashi, M. Kaplan, G Roupe, and A Vahlne (1991)
Science 253, 317-320
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Histopathologic Staging at Initial Diagnosis of Mycosis Fungoides and the Sezary Syndrome: Definition of Three Distinctive Prognostic Groups.
E. A. Sausville, J. L. Eddy, R. W. Makuch, A. B. Fischmann, G. P. Schechter, M. Matthews, E. Glatstein, D. C. Ihde, F. Kaye, S. R. Veach, et al. (1988)
Ann Intern Med 109, 372-382
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