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Science 11 December 1987:
Vol. 238. no. 4833, pp. 1566 - 1568
DOI: 10.1126/science.3685994
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Articles

Science, Vol 238, Issue 4833, 1566-1568
Copyright © 1987 by American Association for the Advancement of Science

articles

Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

N Horiuchi, MP Caulfield, JE Fisher, ME Goldman, RL McKee, JE Reagan, JJ Levy, RF Nutt, SB Rodan, TL Schofield, and al. et

Regional Bone Center, Helen Hayes Hospital (New York State Department of Health), West Haverstraw 10993.

One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.


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