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Science 20 November 1987:
Vol. 238. no. 4830, pp. 1142 - 1144
DOI: 10.1126/science.3120313
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Articles

Science, Vol 238, Issue 4830, 1142-1144
Copyright © 1987 by American Association for the Advancement of Science

articles

A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions

TC Sudhof, F Lottspeich, P Greengard, E Mehl, and R Jahn

Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Health Science Center, Dallas 75235.

Complementary DNA and genomic clones were isolated and sequenced corresponding to rat and human synaptophysin (p38), a major integral membrane protein of synaptic vesicles. The deduced amino acid sequences indicate an evolutionarily highly conserved protein that spans the membrane four times. Both amino and carboxyl termini face the cytoplasm, with the latter containing ten copies of a tyrosine-rich pentapeptide repeat. The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.


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