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Science 20 November 1987:
Vol. 238. no. 4830, pp. 1079 - 1087
DOI: 10.1126/science.3317825

Articles

Science, Vol 238, Issue 4830, 1079-1087
Copyright © 1987 by American Association for the Advancement of Science


articles

Development of the primary antibody repertoire

FW Alt, TK Blackwell, and GD Yancopoulos

Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032.

The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.


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