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Science 6 November 1987: Vol. 238. no. 4828, pp. 797 - 799 DOI: 10.1126/science.3672127
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Articles
Science, Vol 238, Issue 4828, 797-799
Copyright © 1987 by American Association for the Advancement of Science
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
J Milbrandt
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone was examined in the NGF-responsive cell line PC12. Differential hybridization was used to screen a complementary DNA library constructed from PC12 cells treated with NGF and cycloheximide. One of the complementary DNA clones that was rapidly induced by NGF was found to have a nucleotide sequence that predicts a 54-kilodalton protein with homology to transcriptional regulatory proteins. This clone, NGFI-A, contains three tandemly repeated copies of the 28- to 30-amino acid "zinc finger" domain present in Xenopus laevis TFIIIA and other DNA-binding proteins. It also contains another highly conserved unit of eight amino acids that is repeated at least 11 times. The NGFI-A gene is expressed at relatively high levels in the brain, lung, and superior cervical ganglion of the adult rat.
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J. Immunol.
165, 286-291
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- Role of Egr1 in Hippocampal Synaptic Enhancement Induced by Tetanic Stimulation and Amputation.
- F. Wei, Z. C. Xu, Z. Qu, J. Milbrandt, and M. Zhuo (2000)
J. Cell Biol.
149, 1325-1334
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- Regulation of Tissue Factor Gene Expression In Human Endometrium by Transcription Factors Sp1 and Sp3.
- G. Krikun, F. Schatz, N. Mackman, S. Guller, R. Demopoulos, and C. J. Lockwood (2000)
Mol. Endocrinol.
14, 393-400
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- Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice.
- N. Saadane, L. Alpert, and L. E. Chalifour (2000)
Am J Physiol Heart Circ Physiol
278, H796-H805
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- Inhibition of the RelA(p65) NF-kappa B Subunit by Egr-1.
- N. R. Chapman and N. D. Perkins (2000)
J. Biol. Chem.
275, 4719-4725
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- Zinc Finger Transcription Factor Egr-1 Activates Flt-1 Gene Expression in THP-1 Cells on Induction for Macrophage Differentiation.
- N. Akuzawa, M. Kurabayashi, Y. Ohyama, M. Arai, and R. Nagai (2000)
Arterioscler Thromb Vasc Biol
20, 377-384
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- Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain.
- F Mechta-Grigoriou, S Garel, and P Charnay (2000)
Development
127, 119-128
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- Emotional stress induces immediate-early gene expression in rat heart via activation of alpha - and beta -adrenoceptors.
- T. Ueyama, K.-I. Yoshida, and E. Senba (1999)
Am J Physiol Heart Circ Physiol
277, H1553-H1561
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- Brain Gene Expression During REM Sleep Depends on Prior Waking Experience.
- S. Ribeiro, V. Goyal, C. V. Mello, and C. Pavlides (1999)
Learn. Mem.
6, 500-508
| Abstract »
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- Daily Rhythm of Spontaneous Immediate-Early Gene Expression in the Rat Suprachiasmatic Nucleus.
- M. E. Guido, L. B. de Guido, D. Goguen, H. A. Robertson, and B. Rusak (1999)
J Biol Rhythms
14, 275-280
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- The Ras Suppressor, RSU-1, Enhances Nerve Growth Factor-induced Differentiation of PC12 Cells and Induces p21CIP Expression.
- L. Masuelli, S. Ettenberg, F. Vasaturo, K. Vestergaard-Sykes, and M. L. Cutler (1999)
Cell Growth Differ.
10, 555-564
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- Insulin-induced Early Growth Response Gene (Egr-1) Mediates a Short Term Repression of Rat Malic Enzyme Gene Transcription.
- I. Barroso and P. Santisteban (1999)
J. Biol. Chem.
274, 17997-18004
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- CpG oligodeoxynucleotides rescue BKS-2 immature B cell lymphoma from anti-IgM-mediated growth inhibition by up-regulation of egr-1.
- S.-S. Han, S.-T. Chung, D. A. Robertson, R. L. Chelvarajan, and S. Bondada (1999)
Int. Immunol.
11, 871-879
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- Vascular Endothelial Cell Growth Factor-Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1.
- D. Mechtcheriakova, A. Wlachos, H. Holzmuller, B. R. Binder, and E. Hofer (1999)
Blood
93, 3811-3823
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- The Stimulatory Action and the Development of Tolerance to Caffeine Is Associated with Alterations in Gene Expression in Specific Brain Regions.
- P. Svenningsson, G. G. Nomikos, and B. B. Fredholm (1999)
J. Neurosci.
19, 4011-4022
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- Activation of Luteinizing Hormone beta Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1.
- C. Dorn, Q. Ou, J. Svaren, P. A. Crawford, and Y. Sadovsky (1999)
J. Biol. Chem.
274, 13870-13876
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- Early Growth Response Protein 1 Binds to the Luteinizing Hormone-{beta} Promoter and Mediates Gonadotropin-Releasing Hormone-Stimulated Gene Expression.
- M. W. Wolfe and G. B. Call (1999)
Mol. Endocrinol.
13, 752-763
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- Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone beta Gene Transcription.
- J. J. Tremblay and J. Drouin (1999)
Mol. Cell. Biol.
19, 2567-2576
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- COUP-TF Upregulates NGFI-A Gene Expression through an Sp1 Binding Site.
- C. Pipaon, S. Y. Tsai, and M.-J. Tsai (1999)
Mol. Cell. Biol.
19, 2734-2745
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- Ternary Complex Factors Elk-1 and Sap-1a Mediate Growth Hormone-Induced Transcription of Egr-1 (Early Growth Response Factor-1) in 3T3-F442A Preadipocytes.
- R. W. E. Clarkson, C. A. Shang, L. K. Levitt, T. Howard, and M. J. Waters (1999)
Mol. Endocrinol.
13, 619-631
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- Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use.
- B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau (1999)
Pharmacol. Rev.
51, 83-133
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- Pathways of Egr-1-Mediated Gene Transcription in Vascular Biology.
- E. S. Silverman and T. Collins (1999)
Am. J. Pathol.
154, 665-670
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- Mitogenic Up-regulation of the PRL-1 Protein-tyrosine Phosphatase Gene by Egr-1. Egr-1 ACTIVATION IS AN EARLY EVENT IN LIVER REGENERATION.
- Y. Peng, K. Du, S. Ramirez, R. H. Diamond, and R. Taub (1999)
J. Biol. Chem.
274, 4513-4520
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