Science 30 October 1987: Vol. 238. no. 4827, pp. 688 - 692 DOI: 10.1126/science.3499668

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Articles

Specific Expression and Regulation of Hepassocin in the Liver and Down-regulation of the Correlation of HNF1{alpha} with Decreased Levels of Hepassocin in Human Hepatocellular Carcinoma.

H.-T. Yu, M. Yu, C.-Y. Li, Y.-Q. Zhan, W.-X. Xu, Y.-H. Li, W. Li, Z.-D. Wang, C.-H. Ge, and X.-M. Yang (2009)
J. Biol. Chem. 284, 13335-13347
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Prospero-related homeobox protein (Prox1) inhibits hepatitis B virus replication through repressing multiple cis regulatory elements.

J. Qin, J. Zhai, R. Hong, S. Shan, Y. Kong, Y. Wen, Y. Wang, J. Liu, and Y. Xie (2009)
J. Gen. Virol. 90, 1246-1255
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Identification and Characterization of Proximal Promoter Polymorphisms in the Human Concentrative Nucleoside Transporter 2 (SLC28A2).

S. W. Yee, J. E. Shima, S. Hesselson, L. Nguyen, S. De Val, R. J. LaFond, M. Kawamoto, S. J. Johns, D. Stryke, P.-Y. Kwok, et al. (2009)
J. Pharmacol. Exp. Ther. 328, 699-707
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Na+-Glucose Transporter-2 Messenger Ribonucleic Acid Expression in Kidney of Diabetic Rats Correlates with Glycemic Levels: Involvement of Hepatocyte Nuclear Factor-1{alpha} Expression and Activity.

H. S. Freitas, G. F. Anhe, K. F. S. Melo, M. M. Okamoto, M. Oliveira-Souza, S. Bordin, and U. F. Machado (2008)
Endocrinology 149, 717-724
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HNF1{alpha} Inactivation Promotes Lipogenesis in Human Hepatocellular Adenoma Independently of SREBP-1 and Carbohydrate-response Element-binding Protein (ChREBP) Activation.

S. Rebouissou, S. Imbeaud, C. Balabaud, V. Boulanger, J. Bertrand-Michel, F. Terce, C. Auffray, P. Bioulac-Sage, and J. Zucman-Rossi (2007)
J. Biol. Chem. 282, 14437-14446
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Gata4 and Hnf1{alpha} are partially required for the expression of specific intestinal genes during development.

T. Bosse, J. J. Fialkovich, C. M. Piaseckyj, E. Beuling, H. Broekman, R. J. Grand, R. K. Montgomery, and S. D. Krasinski (2007)
Am J Physiol Gastrointest Liver Physiol 292, G1302-G1314
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Computational analysis of tissue-specific combinatorial gene regulation: predicting interaction between transcription factors in human tissues.

X. Yu, J. Lin, D. J. Zack, and J. Qian (2006)
Nucleic Acids Res. 34, 4925-4936
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Hepatocyte nuclear factor-1{alpha} is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo.

T. Bosse, H. M. van Wering, M. Gielen, L. N. Dowling, J. J. Fialkovich, C. M. Piaseckyj, F. J. Gonzalez, T. E. Akiyama, R. K. Montgomery, R. J. Grand, et al. (2006)
Am J Physiol Gastrointest Liver Physiol 290, G1016-G1024
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CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.

E. W. Abrams and D. J. Andrew (2005)
Development 132, 2743-2758
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A Genome Search for Genetic Determinants That Influence Plasma Fibrinogen Levels.

J. M. Soria, L. Almasy, J. C. Souto, A. Buil, M. Lathrop, J. Blangero, and J. Fontcuberta (2005)
Arterioscler Thromb Vasc Biol 25, 1287-1292
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Hepatocyte Nuclear Factor-1{beta} (HNF-1{beta}) C-terminal Domain in Pkhd1 (ARPKD) Gene Transcription and Renal Cystogenesis.

T. Hiesberger, X. Shao, E. Gourley, A. Reimann, M. Pontoglio, and P. Igarashi (2005)
J. Biol. Chem. 280, 10578-10586
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Germline hepatocyte nuclear factor 1{alpha} and 1{beta} mutations in renal cell carcinomas.

S. Rebouissou, V. Vasiliu, C. Thomas, C. Bellanne-Chantelot, H. Bui, Y. Chretien, J. Timsit, C. Rosty, P. Laurent-Puig, D. Chauveau, et al. (2005)
Hum. Mol. Genet. 14, 603-614
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Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.

A. M. Anisfeld, H. R. Kast-Woelbern, H. Lee, Y. Zhang, F. Y. Lee, and P. A. Edwards (2005)
J. Lipid Res. 46, 458-468
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HNF-1{alpha} and endodermal transcription factors cooperatively activate Fabpl: MODY3 mutations abrogate cooperativity.

J. K. Divine, S. P. McCaul, and T. C. Simon (2003)
Am J Physiol Gastrointest Liver Physiol 285, G62-G72
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Hyperphenylalaninemia and Impaired Glucose Tolerance in Mice Lacking the Bifunctional DCoH Gene.

J. H. Bayle, F. Randazzo, G. Johnen, S. Kaufman, A. Nagy, J. Rossant, and G. R. Crabtree (2002)
J. Biol. Chem. 277, 28884-28891
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Physical Interaction between GATA-5 and Hepatocyte Nuclear Factor-1alpha Results in Synergistic Activation of the Human Lactase-Phlorizin Hydrolase Promoter.

H. M. van Wering, I. L. Huibregtse, S. M. van der Zwan, M. S. de Bie, L. N. Dowling, F. Boudreau, E. H. H. M. Rings, R. J. Grand, and S. D. Krasinski (2002)
J. Biol. Chem. 277, 27659-27667
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The Role of Hepatic Nuclear Factor 1alpha and PDX-1 in Transcriptional Regulation of the pdx-1 Gene.

K. Gerrish, M. A. Cissell, and R. Stein (2001)
J. Biol. Chem. 276, 47775-47784
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Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1{alpha}.

S. D. Krasinski, H. M. Van Wering, M. R. Tannemaat, and R. J. Grand (2001)
Am J Physiol Gastrointest Liver Physiol 281, G69-G84
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Hepatic Nuclear Factor 1-{alpha} Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets.

M. Párrizas, M. A. Maestro, S. F. Boj, A. Paniagua, R. Casamitjana, R. Gomis, F. Rivera, and J. Ferrer (2001)
Mol. Cell. Biol. 21, 3234-3243
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Regulation of the Pancreatic Pro-Endocrine Gene Neurogenin3.

J. C. Lee, S. B. Smith, H. Watada, J. Lin, D. Scheel, J. Wang, R. G. Mirmira, and M. S. German (2001)
Diabetes 50, 928-936
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Transcription factors in mouse lung development and function.

R. H. Costa, V. V. Kalinichenko, and L. Lim (2001)
Am J Physiol Lung Cell Mol Physiol 280, L823-L838
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Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury.

J. I. Leu, M. A. S. Crissey, J. P. Leu, G. Ciliberto, and R. Taub (2001)
Mol. Cell. Biol. 21, 414-424
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The I27L Amino Acid Polymorphism of Hepatic Nuclear Factor-1{alpha} Is Associated with Insulin Resistance.

K. C. Chiu, L.-M. Chuang, J. M. Ryu, G. P. Tsai, and M. F. Saad (2000)
J. Clin. Endocrinol. Metab. 85, 2178-2183
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Differential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.

P. Rollini and R. E. K. Fournier (2000)
Nucleic Acids Res. 28, 1767-1777
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Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease.

D. A. Lane and P. J. Grant (2000)
Blood 95, 1517-1532
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The Private Hepatocyte Nuclear Factor-1{alpha} G319S Variant Is Associated With Plasma Lipoprotein Variation in Canadian Oji-Cree.

R. A. Hegele, H. Cao, S. B. Harris, A. J. G. Hanley, B. Zinman, and P. W. Connelly (2000)
Arterioscler Thromb Vasc Biol 20, 217-222
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Anatomy of a Homeoprotein Revealed by the Analysis of Human MODY3 Mutations.

M. Vaxillaire, A. Abderrahmani, P. Boutin, B. Bailleul, P. Froguel, M. Yaniv, and M. Pontoglio (1999)
J. Biol. Chem. 274, 35639-35646
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The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.

P. Rollini and R. E. K. Fournier (1999)
PNAS 96, 10308-10313
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The Promoter of the C1 Inhibitor Gene Contains a Polypurine{middle dot}Polypyrimidine Segment that Enhances Transcriptional Activity.

K. Zahedi, J. J. Bissler, A. E. Prada, J. A. Prada, and A. E. Davis III (1999)
J. Immunol. 162, 7249-7255
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E.B. Wilson Lecture, 1998. Eukaryotic RNAs: Once More from the Beginning ....

J. E. Darnell Jr. (1999)
Mol. Biol. Cell 10, 1685-1692
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Regulation of alpha 1-antitrypsin gene expression in human intestinal epithelial cell line Caco-2 by HNF-1alpha and HNF-4.

C. Hu and D. H. Perlmutter (1999)
Am J Physiol Gastrointest Liver Physiol 276, G1181-G1194
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The Hepatic Nuclear Factor-1{alpha} G319S Variant Is Associated with Early-Onset Type 2 Diabetes in Canadian Oji-Cree.

R. A. Hegele, H. Cao, S. B. Harris, A. J. G. Hanley, and B. Zinman (1999)
J. Clin. Endocrinol. Metab. 84, 1077-1082
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Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription.

R. S. Streeper, E. M. Eaton, D. H. Ebert, S. C. Chapman, C. A. Svitek, and R. M. O'Brien (1998)
PNAS 95, 9208-9213
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Circadian Periodicity of Intestinal Na+/Glucose Cotransporter 1 mRNA Levels Is Transcriptionally Regulated.

D. B. Rhoads, D. H. Rosenbaum, H. Unsal, K. J. Isselbacher, and L. L. Levitsky (1998)
J. Biol. Chem. 273, 9510-9516
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Hepatocyte nuclear factor-1alpha regulates transcription of the guanylin gene.

J. A. Hochman, D. Sciaky, T. L. Whitaker, J. A. Hawkins, and M. B. Cohen (1997)
Am J Physiol Gastrointest Liver Physiol 273, G833-G841
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Induction of Fibrinogen Biosynthesis and Secretion From Cultured Pulmonary Epithelial Cells.

P. J. Simpson Haidaris (1997)
Blood 89, 873-882
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Characterization of cis-Acting Elements of the Gene for Macrophage-stimulating Protein from the Human. THE INVOLVEMENT OF POSITIVE AND NEGATIVE REGULATORY ELEMENTS.

A. Ueda and T. Yoshimura (1996)
J. Biol. Chem. 271, 20265-20272
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Transcriptional Regulation of the Gene Coding for Human Protein C.

C. H. Miao, W.-T. Ho, D. L. Greenberg, and E. W. Davie (1996)
J. Biol. Chem. 271, 9587-9594
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Tissue-specific Expression of the Nonneuronal Promoter of the Aromatic L-Amino Acid Decarboxylase Gene Is Regulated by Hepatocyte Nuclear Factor 1.

A. Aguanno, R. Afar, and V. R. Albert (1996)
J. Biol. Chem. 271, 4528-4538
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Characterization of the 5`-Flanking Region of the Gene for the alpha Chain of Human Fibrinogen.

C.-H. Hu, J. E. Harris, E. W. Davie, and D. W. Chung (1995)
J. Biol. Chem. 270, 28342-28349
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Characterization of the 5`-Flanking Region of the Gene for the [IMAGE] Chain of Human Fibrinogen.

J. Mizuguchi, C.-H. Hu, Z. Cao, K. R. Loeb, D. W. Chung, and E. W. Davie (1995)
J. Biol. Chem. 270, 28350-28356
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Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator.

J. Endrizzi, J. Cronk, W Wang, G. Crabtree, and T Alber (1995)
Science 268, 556-559
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The inductive effect of a human DNA sequence (HALF1) on the differentiation of a variant rat hepatoma cell (C2) is restricted to episomal forms of the molecule.

K. Ng, J Maigne, and J Deschatrette (1995)
J. Cell Sci. 108, 1703-1713
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Developmental expression of the maternal protein XDCoH, the dimerization cofactor of the homeoprotein LFB1 (HNF1).

E Pogge yon Strandmann and G. Ryffel (1995)
Development 121, 1217-1226
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European Atherosclerosis Research Study: Genotype at the Fibrinogen Locus (G-455-A ß-Gene) Is Associated With Differences in Plasma Fibrinogen Levels in Young Men and Women From Different Regions in Europe : Evidence for Gender-Genotype-Environment Interaction.

S. E. Humphries, S. Ye, P. Talmud, L. Bara, L. Wilhelmsen, and L. Tiret (1995)
Arterioscler Thromb Vasc Biol 15, 96-104
 |  Abstract »  |  Full Text »

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.

S. L. Ang, A. Wierda, D. Wong, K. A. Stevens, S. Cascio, J. Rossant, and K. S. Zaret (1993)
Development 119, 1301-1315
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Invited Review: From Diet to DNA: Dietary Patterning of Gene Expression.

M. M. McGrane and R. W. Hanson (1992)
Nutr Clin Pract 7, 16-21
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Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models.

B Staels and J Auwerx (1992)
Development 115, 1035-1043
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Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.

D. Mendel, P. Khavari, P. Conley, M. Graves, L. Hansen, A Admon, and G. Crabtree (1991)
Science 254, 1762-1767
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HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro..

D B Mendel, L P Hansen, M K Graves, P B Conley, and G R Crabtree (1991)
Genes & Dev. 5, 1042-1056
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Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver..

J Mirkovitch and J E Darnell (1991)
Genes & Dev. 5, 83-93
 |  Abstract »  |  PDF »

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily..

F M Sladek, W M Zhong, E Lai, and J E Darnell (1990)
Genes & Dev. 4, 2353-2365
 |  Abstract »  |  PDF »

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally..

E Lai, V R Prezioso, E Smith, O Litvin, R H Costa, and J E Darnell (1990)
Genes & Dev. 4, 1427-1436
 |  Abstract »  |  PDF »

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors..

D M Simmons, J W Voss, H A Ingraham, J M Holloway, R S Broide, M G Rosenfeld, and L W Swanson (1990)
Genes & Dev. 4, 695-711
 |  Abstract »  |  PDF »

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF..

S Baumhueter, D B Mendel, P B Conley, C J Kuo, C Turk, M K Graves, C A Edwards, G Courtois, and G R Crabtree (1990)
Genes & Dev. 4, 372-379
 |  Abstract »  |  PDF »

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.

E. Emmel, C. Verweij, D. Durand, K. Higgins, E Lacy, and G. Crabtree (1989)
Science 246, 1617-1620
 |  Abstract »  |  PDF »

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells..

A D Friedman, W H Landschulz, and S L McKnight (1989)
Genes & Dev. 3, 1314-1322
 |  Abstract »  |  PDF »

A neuron-specific enhancer of the Drosophila dopa decarboxylase gene..

W A Johnson, C A McCormick, S J Bray, and J Hirsh (1989)
Genes & Dev. 3, 676-686
 |  Abstract »  |  PDF »

The role of cis-acting promoter elements in tissue-specific albumin gene expression.

P Maire, J Wuarin, and U Schibler (1989)
Science 244, 343-346
 |  Abstract »  |  PDF »

Postnatal repression of the alpha-fetoprotein gene is enhancer independent..

S A Camper and S M Tilghman (1989)
Genes & Dev. 3, 537-546
 |  Abstract »  |  PDF »

A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells..

S Cereghini, M Blumenfeld, and M Yaniv (1988)
Genes & Dev. 2, 957-974
 |  Abstract »  |  PDF »

Identification of a putative regulator of early T cell activation genes.

J. Shaw, P. Utz, D. Durand, J. Toole, E. Emmel, and G. Crabtree (1988)
Science 241, 202-205
 |  Abstract »  |  PDF »

Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons..

S C Miller, G K Pavlath, B T Blakely, and H M Blau (1988)
Genes & Dev. 2, 330-340
 |  Abstract »  |  PDF »

One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.

D. Grayson, R. Costa, K. Xanthopoulos, and J. Darnell (1988)
Science 239, 786-788
 |  Abstract »  |  PDF »

A Molecular Link between the Common Phenotypes of Type 1 Glycogen Storage Disease and HNF1alpha -null Mice.

H. Hiraiwa, C.-J. Pan, B. Lin, T. E. Akiyama, F. J. Gonzalez, and J. Y. Chou (2001)
J. Biol. Chem. 276, 7963-7967
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Transacting Factors Responsible for the Tissue-specific Expression of Human Glucose Transporter Type 2 Isoform Gene. COOPERATIVE ROLE OF HEPATOCYTE NUCLEAR FACTORS 1alpha AND 3beta.

J.-Y. Cha, H.-i. Kim, K.-S. Kim, M.-W. Hur, and Y.-h. Ahn (2000)
J. Biol. Chem. 275, 18358-18365
 |  Abstract »  |  Full Text »  |  PDF »

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