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Science 23 October 1987:
Vol. 238. no. 4826, pp. 539 - 542
DOI: 10.1126/science.3659926
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Articles

Science, Vol 238, Issue 4826, 539-542
Copyright © 1987 by American Association for the Advancement of Science

articles

Family study of platelet membrane fluidity in Alzheimer's disease

GS Zubenko, M Wusylko, BM Cohen, F Boller, and I Teply

Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213.

The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, identifies a prominent subgroup of patients with Alzheimer's disease who manifest distinct clinical features. In a family study, the prevalence of this platelet membrane abnormality was 3.2 to 11.5 times higher in asymptomatic, first-degree relatives of probands with Alzheimer's disease than in neurologically healthy control subjects chosen without regard to family history of dementia. The pattern of the platelet membrane abnormality within families was consistent with that of a fully penetrant autosomal dominant trait. Thus, this abnormality of platelet membranes may be an inherited factor that is related to the development of Alzheimer's disease.


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