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Science 16 October 1987:
Vol. 238. no. 4825, pp. 366 - 369
DOI: 10.1126/science.3659920
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Articles

Science, Vol 238, Issue 4825, 366-369
Copyright © 1987 by American Association for the Advancement of Science

articles

Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig

RB Borgens, AR Blight, and ME McGinnis

Center for Paralysis Research, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Applied electric fields were used to promote axonal regeneration in spinal cords of adult guinea pigs. A propriospinal intersegmental reflex (the cutaneous trunci muscle reflex) was used to test lateral tract function after hemisection of the thoracic spinal cord. An electrical field (200 microvolts per millimeter, cathode rostral) applied across the lesion led to functional recovery of the cutaneous trunci muscle reflex in 25 percent of experimental animals, whereas the functional deficit remained in control animals, which were implanted with inactive stimulators.


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