Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Bio

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 October 1987:
Vol. 238. no. 4825, pp. 363 - 366
DOI: 10.1126/science.3659919
Prev | Table of Contents | Next

Articles

Science, Vol 238, Issue 4825, 363-366
Copyright © 1987 by American Association for the Advancement of Science

articles

Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon

SH Chen, G Habib, CY Yang, ZW Gu, BR Lee, SA Weng, Silberman SR, SJ Cai, JP Deslypere, M Rosseneu, and al. et

Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.

The primary structure of human apolipoprotein (apo) B-48 has been deduced and shown by a combination of DNA excess hybridization, sequencing of tryptic peptides, cloned complementary DNAs, and intestinal messenger RNAs (mRNAs) to be the product of an intestinal mRNA with an in-frame UAA stop codon resulting from a C to U change in the codon CAA encoding Gln2153 in apoB-100 mRNA. The carboxyl-terminal Ile2152 of apoB-48 purified from chylous ascites fluid has apparently been cleaved from the initial translation product, leaving Met2151 as the new carboxyl-terminus. These data indicate that approximately 85% of the intestinal mRNAs terminate within approximately 0.1 to 1.0 kilobase downstream from the stop codon. The other approximately 15% have lengths similar to hepatic apoB-100 mRNA even though they have the same in-frame stop codon. The organ-specific introduction of a stop codon to a mRNA appears unprecedented and might have implications for cryptic polyadenylation signal recognition and RNA processing.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Proteasomal degradation restricts the nuclear lifespan of AID.
S. Aoufouchi, A. Faili, C. Zober, O. D'Orlando, S. Weller, J.-C. Weill, and C.-A. Reynaud (2008)
J. Exp. Med. 205, 1357-1368
   Abstract »    Full Text »    PDF »
Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic Retention Signal and Is Not Dependent on RNA Binding.
R. P. Bennett, V. Presnyak, J. E. Wedekind, and H. C. Smith (2008)
J. Biol. Chem. 283, 7320-7327
   Abstract »    Full Text »    PDF »
Missense Mutations in APOB within the beta{alpha}1 Domain of Human APOB-100 Result in Impaired Secretion of ApoB and ApoB-containing Lipoproteins in Familial Hypobetalipoproteinemia.
J. R. Burnett, S. Zhong, Z. G. Jiang, A. J. Hooper, E. A. Fisher, R. S. McLeod, Y. Zhao, P. H. R. Barrett, R. A. Hegele, F. M. van Bockxmeer, et al. (2007)
J. Biol. Chem. 282, 24270-24283
   Abstract »    Full Text »    PDF »
An accurate fluorescent assay for quantifying the extent of RNA editing.
L. M. Roberson and J. J.C. Rosenthal (2006)
RNA 12, 1907-1912
   Abstract »    Full Text »    PDF »
Metabolic regulation of ApoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor.
D. M. Lehmann, C. A. Galloway, M. P. Sowden, and H. C. Smith (2006)
Nucleic Acids Res. 34, 3299-3308
   Abstract »    Full Text »    PDF »
A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice.
T. Iwaki, M. J. Sandoval-Cooper, M. Brechmann, V. A. Ploplis, and F. J. Castellino (2006)
Blood 107, 3883-3891
   Abstract »    Full Text »    PDF »
Assembly of Lipoprotein Particles Containing Apolipoprotein-B: Structural Model for the Nascent Lipoprotein Particle.
P. E. Richardson, M. Manchekar, N. Dashti, M. K. Jones, A. Beigneux, S. G. Young, S. C. Harvey, and J. P. Segrest (2005)
Biophys. J. 88, 2789-2800
   Abstract »    Full Text »    PDF »
NMR structure of the apoB mRNA stem-loop and its interaction with the C to U editing APOBEC1 complementary factor.
C. MARIS, J. MASSE, A. CHESTER, N. NAVARATNAM, and F. H.-T. ALLAIN (2005)
RNA 11, 173-186
   Abstract »    Full Text »    PDF »
A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle.
R. D. Bagshaw, D. J. Mahuran, and J. W. Callahan (2005)
Mol. Cell. Proteomics 4, 133-143
   Abstract »    Full Text »    PDF »
Optimization of apolipoprotein B mRNA editing by APOBEC1 apoenzyme and the role of its auxiliary factor, ACF.
A. CHESTER, V. WEINREB, C. W. CARTER JR., and N. NAVARATNAM (2004)
RNA 10, 1399-1411
   Abstract »    Full Text »    PDF »
Interrelationships Between Human Apolipoprotein A-I and Apolipoproteins B-48 and B-100 Kinetics Using Stable Isotopes.
F. K. Welty, A. H. Lichtenstein, P. H. R. Barrett, G. G. Dolnikowski, and E. J. Schaefer (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1703-1707
   Abstract »    Full Text »    PDF »
Advantages and Disadvantages of Cytidine Deamination.
M. Cascalho (2004)
J. Immunol. 172, 6513-6518
   Abstract »    Full Text »    PDF »
Identification of Novel Alternative Splice Variants of APOBEC-1 Complementation Factor with Different Capacities to Support Apolipoprotein B mRNA Editing.
M. P. Sowden, D. M. Lehmann, X. Lin, C. O. Smith, and H. C. Smith (2004)
J. Biol. Chem. 279, 197-206
   Abstract »    Full Text »    PDF »
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.
H. McCarthy, W. G. Wierda, L. L. Barron, C. C. Cromwell, J. Wang, K. R. Coombes, R. Rangel, K. S. J. Elenitoba-Johnson, M. J. Keating, and L. V. Abruzzo (2003)
Blood 101, 4903-4908
   Abstract »    Full Text »    PDF »
In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1).
S. K. Petersen-Mahrt and M. S. Neuberger (2003)
J. Biol. Chem. 278, 19583-19586
   Abstract »    Full Text »    PDF »
Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences.
G. N. Fredrikson, I. Soderberg, M. Lindholm, P. Dimayuga, K.-Y. Chyu, P. K. Shah, and J. Nilsson (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 879-884
   Abstract »    Full Text »    PDF »
A Novel Nontruncating APOB Gene Mutation, R463W, Causes Familial Hypobetalipoproteinemia.
J. R. Burnett, J. Shan, B. A. Miskie, A. J. Whitfield, J. Yuan, K. Tran, C. J. McKnight, R. A. Hegele, and Z. Yao (2003)
J. Biol. Chem. 278, 13442-13452
   Abstract »    Full Text »    PDF »
ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice.
M. E. Hinsdale, P. M. Sullivan, H. Mezdour, and N. Maeda (2002)
J. Lipid Res. 43, 1520-1528
   Abstract »    Full Text »    PDF »
Sources and properties of triglyceride-rich lipoproteins containing apoB-48 and apoB-100 in postprandial blood plasma of patients with primary combined hyperlipidemia.
J. Kovar and R. J. Havel (2002)
J. Lipid Res. 43, 1026-1034
   Abstract »    Full Text »    PDF »
Reconstitution of mRNA Editing in Yeast Using a Gal4-ApoB-Gal80 Fusion Transcript as the Selectable Marker.
H. Lellek, S. Welker, I. Diehl, R. Kirsten, and J. Greeve (2002)
J. Biol. Chem. 277, 23638-23644
   Abstract »    Full Text »    PDF »
Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride.
T. Y. Hui, L. M. Olivier, S. Kang, and R. A. Davis (2002)
J. Lipid Res. 43, 785-793
   Abstract »    Full Text »    PDF »
Two Proteins Essential for Apolipoprotein B mRNA Editing Are Expressed from a Single Gene through Alternative Splicing.
G. S. C. Dance, M. P. Sowden, L. Cartegni, E. Cooper, A. R. Krainer, and H. C. Smith (2002)
J. Biol. Chem. 277, 12703-12709
   Abstract »    Full Text »    PDF »
Apolipoprotein B mRNA Editing and the Reduction in Synthesis and Secretion of the Atherogenic Risk Factor, Apolipoprotein B100 Can Be Effectively Targeted through TAT-Mediated Protein Transduction.
Y. Yang, N. Ballatori, and H. C. Smith (2002)
Mol. Pharmacol. 61, 269-276
   Abstract »    Full Text »    PDF »
Novel Role for RNA-binding Protein CUGBP2 in Mammalian RNA Editing. CUGBP2 MODULATES C TO U EDITING OF APOLIPOPROTEIN B mRNA BY INTERACTING WITH APOBEC-1 AND ACF, THE APOBEC-1 COMPLEMENTATION FACTOR.
S. Anant, J. O. Henderson, D. Mukhopadhyay, N. Navaratnam, S. Kennedy, J. Min, and N. O. Davidson (2001)
J. Biol. Chem. 276, 47338-47351
   Abstract »    Full Text »    PDF »
ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing.
S. Anant, D. Mukhopadhyay, V. Sankaranand, S. Kennedy, J. O. Henderson, and N. O. Davidson (2001)
Am J Physiol Cell Physiol 281, C1904-C1916
   Abstract »    Full Text »    PDF »
Mutagenesis of Apobec-1 Complementation Factor Reveals Distinct Domains That Modulate RNA Binding, Protein-Protein Interaction with Apobec-1, and Complementation of C to U RNA-editing Activity.
V. Blanc, J. O. Henderson, S. Kennedy, and N. O. Davidson (2001)
J. Biol. Chem. 276, 46386-46393
   Abstract »    Full Text »    PDF »
A DnaJ Protein, Apobec-1-binding Protein-2, Modulates Apolipoprotein B mRNA Editing.
P. P. Lau, H. Villanueva, K. Kobayashi, M. Nakamuta, B. H.-J. Chang, and L. Chan (2001)
J. Biol. Chem. 276, 46445-46452
   Abstract »    Full Text »    PDF »
Direct effects of growth hormone on production and secretion of apolipoprotein B from rat hepatocytes.
D. Linden, A. Sjoberg, L. Asp, L. Carlsson, and J. Oscarsson (2000)
Am J Physiol Endocrinol Metab 279, E1335-E1346
   Abstract »    Full Text »    PDF »
Regulation of Intestinal Apolipoprotein B mRNA Editing Levels by a Zinc-Deficient Diet and cDNA Cloning of Editing Protein in Hamsters.
S. K. Reaves, J. Y. J. Wu, Y. Wu, J. C. Fanzo, Y. R. Wang, P. P. Lei, and K. Y. Lei (2000)
J. Nutr. 130, 2166-2173
   Abstract »    Full Text »
Effects of ApoE Genotype on ApoB-48 and ApoB-100 Kinetics With Stable Isotopes in Humans.
F. K. Welty, A. H. Lichtenstein, P. H. R. Barrett, J. L. Jenner, G. G. Dolnikowski, and E. J. Schaefer (2000)
Arterioscler. Thromb. Vasc. Biol. 20, 1807-1810
   Abstract »    Full Text »    PDF »
An AU-Rich Sequence Element (UUUN[A/U]U) Downstream of the Edited C in Apolipoprotein B mRNA Is a High-Affinity Binding Site for Apobec-1: Binding of Apobec-1 to This Motif in the 3' Untranslated Region of c-myc Increases mRNA Stability.
S. Anant and N. O. Davidson (2000)
Mol. Cell. Biol. 20, 1982-1992
   Abstract »    Full Text »
Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA.
A. Mehta, M. T. Kinter, N. E. Sherman, and D. M. Driscoll (2000)
Mol. Cell. Biol. 20, 1846-1854
   Abstract »    Full Text »
Apolipoprotein B, a Paradigm for Proteins Regulated by Intracellular Degradation, Does Not Undergo Intracellular Degradation in CaCo2 Cells.
W. Liao and L. Chan (2000)
J. Biol. Chem. 275, 3950-3956
   Abstract »    Full Text »    PDF »
The Properties of a tRNA-Specific Adenosine Deaminase from Drosophila melanogaster Support an Evolutionary Link between Pre-mRNA Editing and tRNA Modification.
L. P. Keegan, A. P. Gerber, J. Brindle, R. Leemans, A. Gallo, W. Keller, and M. A. O'Connell (2000)
Mol. Cell. Biol. 20, 825-833
   Abstract »    Full Text »
APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.
G. S. C. Dance, M. P. Sowden, Y. Yang, and H. C. Smith (2000)
Nucleic Acids Res. 28, 424-429
   Abstract »    Full Text »    PDF »
Rat McA-RH7777 cells efficiently assemble rat apolipoprotein B-48 or larger fragments into VLDL but not human apolipoprotein B of any size.
Q. Xiao, J. Elovson, and V. N. Schumaker (2000)
J. Lipid Res. 41, 116-125
   Abstract »    Full Text »
Phylogenetic Analysis of the Apolipoprotein B mRNA-editing Region. EVIDENCE FOR A SECONDARY STRUCTURE BETWEEN THE MOORING SEQUENCE AND THE 3' EFFICIENCY ELEMENT.
M. Hersberger, S. Patarroyo-White, K. S. Arnold, and T. L. Innerarity (1999)
J. Biol. Chem. 274, 34590-34597
   Abstract »    Full Text »    PDF »
Human Apolipoprotein (Apo) B-48 and ApoB-100 Kinetics With Stable Isotopes.
F. K. Welty, A. H. Lichtenstein, P. H. R. Barrett, G. G. Dolnikowski, and E. J. Schaefer (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 2966-2974
   Abstract »    Full Text »    PDF »
Genetic control of hepatic apoB-100 secretion in human apoB transgenic mouse strains.
E. Voyiaziakis, C. Ko, S. M. O'Rourke, and L.-S. Huang (1999)
J. Lipid Res. 40, 2004-2012
   Abstract »    Full Text »
Increased dietary triacylglycerol markedly enhances the ability of isolated rabbit enterocytes to secrete chylomicrons: an effect related to dietary fatty acid composition.
I. J. Cartwright and J. A. Higgins (1999)
J. Lipid Res. 40, 1858-1866
   Abstract »    Full Text »
Plasma Apolipoprotein B-48, Hepatic Apolipoprotein B mRNA Editing and Apolipoprotein B mRNA Editing Catalytic Subunit-1 mRNA Levels Are Altered in Zinc-Deficient Rats.
S. K. Reaves, J. C. Fanzo, J. Y. J. Wu, Y. R. Wang, Y. W. Wu, L. Zhu, and K. Y. Lei (1999)
J. Nutr. 129, 1855-1861
   Abstract »    Full Text »
A functional polymorphism in the apolipoprotein B promoter that influences the level of plasma low density lipoprotein.
F. M. van 't Hooft, S. Jormsjö, B. Lundahl, P. Tornvall, P. Eriksson, and A. Hamsten (1999)
J. Lipid Res. 40, 1686-1694
   Abstract »    Full Text »
Hammerhead Ribozyme Cleavage of Apolipoprotein B mRNA Generates a Truncated Protein.
J.-P. Wang, M. Enjoji, M. Tiebel, S. Ochsner, L. Chan, and B.-B. Teng (1999)
J. Biol. Chem. 274, 24161-24170
   Abstract »    Full Text »    PDF »
Genetic Deficiency of Acylation Stimulating Protein (ASP(C3ades-Arg)) Does Not Cause Hyperapobetalipoproteinemia in Mice.
R. A. Wetsel, J. Kildsgaard, E. Zsigmond, W. Liao, and L. Chan (1999)
J. Biol. Chem. 274, 19429-19433
   Abstract »    Full Text »    PDF »
Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization.
B.-B. Teng, S. Ochsner, Q. Zhang, K. V. Soman, P. P. Lau, and L. Chan (1999)
J. Lipid Res. 40, 623-635
   Abstract »    Full Text »
Assembly of Very Low Density Lipoprotein: A Two-Step Process of Apolipoprotein B Core Lipidation.
S. Rustaeus, K. Lindberg, P. Stillemark, C. Claesson, L. Asp, T. Larsson, J. Boren, and S.-O. Olofsson (1999)
J. Nutr. 129, 463
   Abstract »    Full Text »    PDF »
Identification of Domains in Apolipoprotein B100 That Confer a High Requirement for the Microsomal Triglyceride Transfer Protein.
E. Nicodeme, F. Benoist, R. McLeod, Z. Yao, J. Scott, C. C. Shoulders, and T. Grand-Perret (1999)
J. Biol. Chem. 274, 1986-1993
   Abstract »    Full Text »    PDF »
Secondary Structure for the Apolipoprotein B mRNA Editing Site. AU-BINDING PROTEINS INTERACT WITH A STEM LOOP.
N. Richardson, N. Navaratnam, and J. Scott (1998)
J. Biol. Chem. 273, 31707-31717
   Abstract »    Full Text »    PDF »
A Sequence-Specific RNA-Binding Protein Complements Apobec-1 To Edit Apolipoprotein B mRNA.
A. Mehta and D. M. Driscoll (1998)
Mol. Cell. Biol. 18, 4426-4432
   Abstract »    Full Text »
Distinct Promoters Induce APOBEC-1 Expression in Rat Liver and Intestine.
J. Greeve, D. Axelos, S. Welker, M. Schipper, and H. Greten (1998)
Arterioscler. Thromb. Vasc. Biol. 18, 1079-1092
   Abstract »    Full Text »    PDF »
Expression and Conservation of Apolipoprotein AIV in an Avian Species.
A. Steinmetz, M. Hermann, J. Nimpf, R. Aebersold, A. Ducret, R. B. Weinberg, and W. J. Schneider (1998)
J. Biol. Chem. 273, 10543-10549
   Abstract »    Full Text »    PDF »
Two Efficiency Elements Flanking the Editing Site of Cytidine 6666 in the Apolipoprotein B mRNA Support Mooring-dependent Editing.
M. Hersberger and T. L. Innerarity (1998)
J. Biol. Chem. 273, 9435-9442
   Abstract »    Full Text »    PDF »
Genetically modified mice for the study of apolipoprotein B.
E. Kim and S. G. Young (1998)
J. Lipid Res. 39, 703-723
   Abstract »    Full Text »    PDF »
The Enzymatic and Non-enzymatic Roles of Protein-disulfide Isomerase in Apolipoprotein B Secretion.
L. Wang, D. G. Fast, and A. D. Attie (1997)
J. Biol. Chem. 272, 27644-27651
   Abstract »    Full Text »    PDF »
Dietary Fat Clearance in Normal Subjects Is Modulated by Genetic Variation at the Apolipoprotein B Gene Locus.
J. Lopez-Miranda, J.M. Ordovas, M.A. Ostos, C. Marin, S. Jansen, J. Salas, A. Blanco-Molina, J.A. Jimenez-Pereperez, F. Lopez-Segura, and F. Perez-Jimenez (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 1765-1773
   Abstract »    Full Text »
Decreased Production and Increased Catabolism of Apolipoprotein B-100 in Apolipoprotein B-67/B-100 Heterozygotes.
F. K. Welty, A. H. Lichtenstein, P. H. R. Barrett, G. G. Dolnikowski, J. M. Ordovas, and E. J. Schaefer (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 881-888
   Abstract »    Full Text »
Effective Lowering of Plasma, LDL, and Esterified Cholesterol in LDL Receptor–Knockout Mice by Adenovirus-Mediated Gene Delivery of ApoB mRNA Editing Enzyme (Apobec1).
B. Teng, B. Ishida, T. M. Forte, S. Blumenthal, L.-Z. Song, A. M. Gotto Jr, and L. Chan (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 889-897
   Abstract »    Full Text »
Uptake by J774 Macrophages of Very-Low-Density Lipoproteins Isolated From ApoE-Deficient Mice Is Mediated by a Distinct Receptor and Stimulated by Lipoprotein Lipase.
W. L. Hendriks, F. van der Sman-de Beer, B. J.M. van Vlijmen, L. C. van Vark, M. H. Hofker, and L. M. Havekes (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 498-504
   Abstract »    Full Text »
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme..
S Yamanaka, K S Poksay, K S Arnold, and T L Innerarity (1997)
Genes & Dev. 11, 321-333
   Abstract »    PDF »
Cloning of an Apobec-1-binding Protein That Also Interacts with Apolipoprotein B mRNA and Evidence for Its Involvement in RNA Editing.
P. P. Lau, H.-J. Zhu, M. Nakamuta, and L. Chan (1997)
J. Biol. Chem. 272, 1452-1455
   Abstract »    Full Text »    PDF »
Tissue-specific Inhibition of Apolipoprotein B mRNA Editing in the Liver by Adenovirus-mediated Transfer of a Dominant Negative Mutant APOBEC-1 Leads to Increased Low Density Lipoprotein in Mice.
K. Oka, K. Kobayashi, M. Sullivan, J. Martinez, B.-B. Teng, K. Ishimura-Oka, and L. Chan (1997)
J. Biol. Chem. 272, 1456-1460
   Abstract »    Full Text »    PDF »
Purification of Human Double-stranded RNA-specific Editase 1(hRED1) Involved in Editing of Brain Glutamate Receptor B Pre-mRNA.
M. A. O'Connell, A. Gerber, and W. Keller (1997)
J. Biol. Chem. 272, 473-478
   Abstract »    Full Text »    PDF »
In the Absence of Endogenous Mouse Apolipoprotein E, Apolipoprotein E*2(Arg-158 right-arrow Cys) Transgenic Mice Develop More Severe Hyperlipoproteinemia than Apolipoprotein E*3-Leiden Transgenic Mice.
B. J.M. van Vlijmen, K. W. van Dijk, H. B. van't Hof, P. J.J. van Gorp, A. van der Zee, H. van der Boom, M. L. Breuer, M. H. Hofker, and L. M. Havekes (1996)
J. Biol. Chem. 271, 30595-30602
   Abstract »    Full Text »    PDF »
Apobec-1 Interacts with a 65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro.
A. Mehta, S. Banerjee, and D. M. Driscoll (1996)
J. Biol. Chem. 271, 28294-28299
   Abstract »    Full Text »    PDF »
Complete Phenotypic Characterization of apobec-1 Knockout Mice with a Wild-type Genetic Background and a Human Apolipoprotein B Transgenic Background, and Restoration of Apolipoprotein B mRNA Editing by Somatic Gene Transfer of Apobec-1.
M. Nakamuta, B. H.-J. Chang, E. Zsigmond, K. Kobayashi, H. Lei, B. Y. Ishida, K. Oka, E. Li, and L. Chan (1996)
J. Biol. Chem. 271, 25981-25988
   Abstract »    Full Text »    PDF »
Hyperediting of Multiple Cytidines of Apolipoprotein B mRNA by APOBEC-1 Requires Auxiliary Protein(s) but Not a Mooring Sequence Motif.
S. Yamanaka, K. S. Poksay, D. M. Driscoll, and T. L. Innerarity (1996)
J. Biol. Chem. 271, 11506-11510
   Abstract »    Full Text »    PDF »
Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48.
K.-I. Hirano, S. G. Young, R. V. Farese Jr., J. Ng, E. Sande, C. Warburton, L. M. Powell-Braxton, and N. O. Davidson (1996)
J. Biol. Chem. 271, 9887-9890
   Abstract »    Full Text »    PDF »
The Amino Terminus of Apolipoprotein B Is Necessary but Not Sufficient for Microsomal Triglyceride Transfer Protein Responsiveness.
D. G. Gretch, S. L. Sturley, L. Wang, B. A. Lipton, A. Dunning, K. A. A. Grunwald, J. R. Wetterau, Z. Yao, P. Talmud, and A. D. Attie (1996)
J. Biol. Chem. 271, 8682-8691
   Abstract »    Full Text »    PDF »
Overexpression of APOBEC-1 Results in Mooring Sequence-dependent Promiscuous RNA Editing.
M. Sowden, J. K. Hamm, and H. C. Smith (1996)
J. Biol. Chem. 271, 3011-3017
   Abstract »    Full Text »    PDF »
Biosynthesis of Apolipoprotein B48-containing Lipoproteins.
T. L. Innerarity, J. Borén, S. Yamanaka, and S.-O. Olofsson (1996)
J. Biol. Chem. 271, 2353-2356
   Full Text »    PDF »
Brefeldin A Reversibly Inhibits the Assembly of ApoB Containing Lipoproteins in McA-RH7777 Cells.
S. Rustaeus, K. Lindberg, J. Borén, and S.-O. Olofsson (1995)
J. Biol. Chem. 270, 28879-28886
   Abstract »    Full Text »    PDF »
Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment.
C.-N. Wang, T. C. Hobman, and D. N. Brindley (1995)
J. Biol. Chem. 270, 24924-24931
   Abstract »    Full Text »    PDF »
Identification and Molecular Analysis of Two ApoB Gene Mutations Causing Low Plasma Cholesterol Levels.
F. K. Welty, J. Ordovas, E. J. Schaefer, P. W.F. Wilson, and S. G. Young (1995)
Circulation 92, 2036-2040
   Abstract »    Full Text »
Evidence for a Site-specific Cytidine Deamination Reaction Involved in C to U RNA Editing of Plant Mitochondria.
W. Yu and W. Schuster (1995)
J. Biol. Chem. 270, 18227-18233
   Abstract »    Full Text »    PDF »
apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Is a Novel RNA-binding Protein.
S. Anant, A. J. MacGinnitie, and N. O. Davidson (1995)
J. Biol. Chem. 270, 14762-14767
   Abstract »    Full Text »    PDF »
Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity.
A. J. MacGinnitie, S. Anant, and N. O. Davidson (1995)
J. Biol. Chem. 270, 14768-14775
   Abstract »    Full Text »    PDF »
Alternative mRNA Splicing and Differential Promoter Utilization Determine Tissue-specific Expression of the Apolipoprotein B mRNA-editing Protein (Apobec1) Gene in Mice.
M. Nakamuta, K. Oka, J. Krushkal, K. Kobayashi, M. Yamamoto, W.-H. Li, and L. Chan (1995)
J. Biol. Chem. 270, 13042-13056
   Abstract »    Full Text »    PDF »
Characterization of Recombinant Human ApoB-48–Containing Lipoproteins in Rat Hepatoma McA-RH7777 Cells Transfected With ApoB-48 cDNA : Overexpression of ApoB-48 Decreases Synthesis of Endogenous ApoB-100.
M. M. Hussain, Y. Zhao, R. K. Kancha, B. D. Blackhart, and Z. Yao (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 485-494
   Abstract »    Full Text »
Molecular cloning of an apolipoprotein B messenger RNA editing protein.
B Teng, C. Burant, and N. Davidson (1993)
Science 260, 1816-1819
   Abstract »    PDF »
Editing of transfer RNAs in Acanthamoeba castellanii mitochondria.
K. Lonergan and M. Gray (1993)
Science 259, 812-816
   Abstract »    PDF »
Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid.
L. Lanier, S Cwirla, G Yu, R Testi, and J. Phillips (1989)
Science 246, 1611-1613
   Abstract »    PDF »
Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord.
H Akagi and R Miledi (1988)
Science 242, 270-273
   Abstract »    PDF »
Purification and Molecular Cloning of a Novel Essential Component of the Apolipoprotein B mRNA Editing Enzyme-Complex.
H. Lellek, R. Kirsten, I. Diehl, F. Apostel, F. Buck, and J. Greeve (2000)
J. Biol. Chem. 275, 19848-19856
   Abstract »    Full Text »    PDF »
A Targeted Apolipoprotein B-38.9-producing Mutation Causes Fatty Livers in Mice Due to the Reduced Ability of Apolipoprotein B-38.9 to Transport Triglycerides.
Z. Chen, R. L. Fitzgerald, M. R. Averna, and G. Schonfeld (2000)
J. Biol. Chem. 275, 32807-32815
   Abstract »    Full Text »    PDF »
O|Identification of GRY-RBP as an Apolipoprotein B RNA-binding Protein That Interacts with Both Apobec-1 and Apobec-1 Complementation Factor to Modulate C to U Editing.
V. Blanc, N. Navaratnam, J. O. Henderson, S. Anant, S. Kennedy, A. Jarmuz, J. Scott, and N. O. Davidson (2001)
J. Biol. Chem. 276, 10272-10283
   Abstract »    Full Text »    PDF »
Chloroplast RNA Editing Required for Functional Acetyl-CoA Carboxylase in Plants.
Y. Sasaki, A. Kozaki, A. Ohmori, H. Iguchi, and Y. Nagano (2001)
J. Biol. Chem. 276, 3937-3940
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT