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Science 16 October 1987:
Vol. 238. no. 4825, pp. 347 - 350
DOI: 10.1126/science.3659917
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Articles

Science, Vol 238, Issue 4825, 347-350
Copyright © 1987 by American Association for the Advancement of Science

articles

Conservation of the Duchenne muscular dystrophy gene in mice and humans

EP Hoffman, AP Monaco, CC Feener, and LM Kunkel

Division of Genetics, Children's Hospital, Boston, MA 02115.

A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.


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