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Science 9 October 1987:
Vol. 238. no. 4824, pp. 185 - 188
DOI: 10.1126/science.3659909
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Articles

Science, Vol 238, Issue 4824, 185-188
Copyright © 1987 by American Association for the Advancement of Science

articles

Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia

IU Ali, R Lidereau, C Theillet, and R Callahan

Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892.

The somatic loss of heterozygosity for normal alleles occurring in human tumors has suggested the presence of recessive oncogenes. The results presented here demonstrate a loss of heterozygosity of several genes on chromosome 11 in primary breast tumors. Restriction fragment length polymorphism analysis of these DNAs further suggests that the most frequent loss of sequences in breast tumors occurs between the beta-globin and parathyroid hormone loci on the short arm of chromosome 11. The loss of heterozygosity for chromosome 11 loci has a significant association with tumors that lack estrogen and progesterone receptors, grade III tumors, and distal metastasis.


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