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Science 24 July 1987:
Vol. 237. no. 4813, pp. 402 - 405
DOI: 10.1126/science.3299705
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Articles

Science, Vol 237, Issue 4813, 402-405
Copyright © 1987 by American Association for the Advancement of Science

articles

Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve

KS Cook, HY Min, D Johnson, RJ Chaplinsky, JS Flier, CR Hunt, and BM Spiegelman

Adipsin is a serine protease homolog whose primary structure was predicted from the nucleotide sequence of a differentiation-dependent adipocyte messenger RNA. Immunoblots probed with antisera to synthetic peptides identify two forms of adipsin that are synthesized and secreted by 3T3 adipocytes. These proteins of 44 and 37 kilodaltons are converted to 25.5 kilodaltons by enzymatic deglycosylation. Although adipsin is principally synthesized in adipose tissue, it is also produced by sciatic nerve and is found in the bloodstream. Because of the apparent restriction of adipsin synthesis to tissues highly active in lipid metabolism, its presence in serum, and its modulation in altered metabolic states, this molecule may play a previously unrecognized role in systemic lipid metabolism or energy balance.


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