Related Content
Search Google Scholar for:
|
|
Science 17 July 1987:
Vol. 237. no. 4812, pp. 293 - 297
DOI: 10.1126/science.3037704
|
|
Articles
Science, Vol 237, Issue 4812, 293-297
Copyright © 1987 by American Association for the Advancement of Science
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II
RM Hanley,
AR Means,
T Ono,
BE Kemp,
KE Burgin,
N Waxham,
and
PT Kelly
The calcium-calmodulin-dependent protein kinase II is a major component of brain synaptic junctions and has been proposed to play a variety of important roles in brain function. A complementary DNA representing a portion of the smaller 50-kilodalton subunit of the rat brain enzyme has been cloned and sequenced. The calmodulin-binding region has been identified and a synthetic analog prepared that binds calmodulin with high affinity in the presence of calcium. Like the 50-kilodalton kinase polypeptide, the concentration of the messenger RNA varies both neuroanatomically and during postnatal development of the brain. The broad tissue and species cross-reactivity of the complementary DNA suggests that the 50-kilodalton subunit found in rat brain is evolutionarily conserved and is the product of a single gene.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Calmodulin Regulates Current Density and Frequency-Dependent Inhibition of Sodium Channel Nav1.8 in DRG Neurons.
- J.-S. Choi, A. Hudmon, S. G. Waxman, and S. D. Dib-Hajj (2006)
J Neurophysiol
96, 97-108
| Abstract »
| Full Text »
| PDF »
- Pavlovian Fear Conditioning Regulates Thr286 Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala Synapses.
- S. M. Rodrigues, C. R. Farb, E. P. Bauer, J. E. LeDoux, and G. E. Schafe (2004)
J. Neurosci.
24, 3281-3288
| Abstract »
| Full Text »
| PDF »
- Identification of Domains Essential for the Assembly of Calcium/Calmodulin-dependent Protein Kinase II Holoenzymes.
- S. J. Kolb, A. Hudmon, T. R. Ginsberg, and M. N. Waxham (1998)
J. Biol. Chem.
273, 31555-31564
| Abstract »
| Full Text »
| PDF »
- Cell- and Lamina-Specific Expression and Activity-Dependent Regulation of Type II Calcium/Calmodulin-Dependent Protein Kinase Isoforms in Monkey Visual Cortex.
- B. Tighilet, T. Hashikawa, and E. G. Jones (1998)
J. Neurosci.
18, 2129-2146
| Abstract »
| Full Text »
| PDF »
- Ca2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: Evidence for direct inhibition of phospholipase C.
- E. A. Richard, S. Ghosh, J. M. Lowenstein, and J. E. Lisman (1997)
PNAS
94, 14095-14099
| Abstract »
| Full Text »
| PDF »
- Ca2+/Calmodulin Causes Rab3A to Dissociate from Synaptic Membranes.
- J. B. Park, C. C. Farnsworth, and J. A. Glomset (1997)
J. Biol. Chem.
272, 20857-20865
| Abstract »
| Full Text »
| PDF »
- Insulinoma Cells Contain an Isoform of Ca2+/Calmodulin-Dependent Protein Kinase II {delta} Associated with Insulin Secretion Vesicles.
- M. Mohlig, S. Wolter, P. Mayer, J. Lang, M. Osterhoff, P. A. Horn, H. Schatz, and A. Pfeiffer (1997)
Endocrinology
138, 2577-2584
| Abstract »
| Full Text »
| PDF »
- A Peptide Model for Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II.
- J. A. Putkey and M. N. Waxham (1996)
J. Biol. Chem.
271, 29619-29623
| Abstract »
| Full Text »
| PDF »
- The Calmodulin-Nitric Oxide Synthase Interaction.
- Z. Su, M. A. Blazing, D. Fan, and S. E. George (1995)
J. Biol. Chem.
270, 29117-29122
| Abstract »
| Full Text »
| PDF »
- Phosphorylation and Activation of Ca[IMAGE]-Calmodulin-dependent Protein Kinase IV by Ca[IMAGE]-Calmodulin-dependent Protein Kinase Ia Kinase.
- M. A. Selbert, K. A. Anderson, Q.-H. Huang, E. G. Goldstein, A. R. Means, and A. M. Edelman (1995)
J. Biol. Chem.
270, 17616-17621
| Abstract »
| Full Text »
| PDF »
- Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
- W. Meador, A. Means, and F. Quiocho (1993)
Science
262, 1718-1721
| Abstract »
| PDF »
- Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.
- W. Meador, A. Means, and F. Quiocho (1992)
Science
257, 1251-1255
| Abstract »
| PDF »
- Solution structure of a calmodulin-target peptide complex by multidimensional NMR.
- M Ikura, G. Clore, A. Gronenborn, G Zhu, C. Klee, and A Bax (1992)
Science
256, 632-638
| Abstract »
| PDF »
- Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPbeta.
- M. Wegner, Z. Cao, and M. G. Rosenfeld (1992)
Science
256, 370-373
| Abstract »
| PDF »
- Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase.
- R. Pearson, R. Wettenhall, A. Means, D. Hartshorne, and B. Kemp (1988)
Science
241, 970-973
| Abstract »
| PDF »
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
- S. Hanks, A. Quinn, and T Hunter (1988)
Science
241, 42-52
| Abstract »
| PDF »
- Regulatory Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase.
- H. Tokumitsu, M.-a. Muramatsu, M. Ikura, and R. Kobayashi (2000)
J. Biol. Chem.
275, 20090-20095
| Abstract »
| Full Text »
| PDF »
- Identification of Novel Bifunctional Calmodulin-binding and Microtubule-stabilizing Motifs in STOP Proteins.
- C. Bosc, R. Frank, E. Denarier, M. Ronjat, A. Schweitzer, J. Wehland, and D. Job (2001)
J. Biol. Chem.
276, 30904-30913
| Abstract »
| Full Text »
| PDF »
|
|
