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Science 19 June 1987:
Vol. 236. no. 4808, pp. 1573 - 1577
DOI: 10.1126/science.3109035
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Articles

Science, Vol 236, Issue 4808, 1573-1577
Copyright © 1987 by American Association for the Advancement of Science

articles

Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility

M Lenardo, JW Pierce, and D Baltimore

Individual protein-binding sites within the mouse immunoglobulin heavy chain and kappa light chain gene enhancers were altered, making it possible to examine the functional role of the sites during transcription. The E motifs, which bind factors that are present in many if not all cells, mostly behave as transcriptional activating sites. The only known heavy chain enhancer site that binds a lymphocyte-specific factor, the "octamer" site, plays a critical role in transcription but only in a truncated form of the enhancer. In the full enhancer, no one site is crucial because of an apparent functional redundancy. The site in the kappa enhancer that binds a factor specific to mature B cells, kappa B, was crucial to the constitutive activity of the enhancer in B cells. This factor is also inducible in pre-B cells, and the site was necessary for inducibility of the kappa enhancer. Thus, the sites defined by protein binding are important for the functional activity of immunoglobulin enhancers, with the sites that bind proteins restricted in their cellular distribution playing the most important roles.


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Genes & Dev. 3, 1255-1266
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A. Winoto and D. Baltimore (1989)
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