Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 May 1987:
Vol. 236. no. 4805, pp. 1103 - 1106
DOI: 10.1126/science.2883731
Prev | Table of Contents | Next

Articles

Science, Vol 236, Issue 4805, 1103-1106
Copyright © 1987 by American Association for the Advancement of Science

articles

HTLV-I--associated B-cell CLL: indirect role for retrovirus in leukemogenesis

DL Mann, P DeSantis, G Mark, A Pfeifer, M Newman, N Gibbs, M Popovic, MG Sarngadharan, RC Gallo, J Clark, and al. et

Serum containing antibodies to the human T-lymphotropic virus type I (HTLV-I) has been observed at a higher than expected frequency in patients with B-cell chronic lymphocytic leukemia (CLL) in an area endemic for HTLV-I. An attempt was made to determine whether the cells from patients with this leukemia were HTLV-I antigen-committed B cells that had undergone malignant transformation. Cells from two HTLV-I seropositive Jamaican patients with CLL were fused with a human B-lymphoblastoid cell line. The hybridoma cells that resulted from the fusion of CLL cells from patient I.C. produced an immunoglobulin (IgM) that reacted with the p24 gag protein from HTLV-I, HTLV-II, and HTLV-III (now referred to as HIV), but showed preferential reactivity with HTLV-I. The specific immunoglobulin gene rearrangement (IgM, kappa) in the CLL cell was demonstrated in the hybridoma cell line, indicating that the captured immunoglobulin was from the CLL cells. The IgM secreted by the fusion of CLL cells from patient L.L. reacted only with HTLV-I-infected cells and with the HTLV-I large envelope protein (gp61) on Western blots. The CLL cells from these patients appear to be a malignant transformation of an antigen-committed B cell responding to HTLV-I infection, suggesting an indirect role for this retrovirus in leukemogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhanced Replication of Human T-Cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner.
R. Takayanagi, T. Ohashi, E. Yamashita, Y. Kurosaki, K. Tanaka, Y. Hakata, Y. Komoda, S. Ikeda, Y. Tsunetsugu-Yokota, Y. Tanaka, et al. (2007)
J. Virol. 81, 5908-5918
   Abstract »    Full Text »    PDF »
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity.
R. J. Bende, W. M. Aarts, R. G. Riedl, D. de Jong, S. T. Pals, and C. J.M. van Noesel (2005)
J. Exp. Med. 201, 1229-1241
   Abstract »    Full Text »    PDF »
Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia.
B. T. Messmer, E. Albesiano, D. G. Efremov, F. Ghiotto, S. L. Allen, J. Kolitz, R. Foa, R. N. Damle, F. Fais, D. Messmer, et al. (2004)
J. Exp. Med. 200, 519-525
   Abstract »    Full Text »    PDF »
Correlation of Major Histocompatibility Complex Class I Downregulation with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Cytotoxic T-Lymphocyte Killing in a Rat Model.
T. Ohashi, S. Hanabuchi, R. Suzuki, H. Kato, T. Masuda, and M. Kannagi (2002)
J. Virol. 76, 7010-7019
   Abstract »    Full Text »    PDF »
Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor.
B. Ciric, V. VanKeulen, M. Rodriguez, R. A. Kyle, M. A. Gertz, and L. R. Pease (2001)
Blood 97, 321-323
   Abstract »    Full Text »    PDF »
Induction of Adult T-Cell Leukemia-Like Lymphoproliferative Disease and Its Inhibition by Adoptive Immunotherapy in T-Cell-Deficient Nude Rats Inoculated with Syngeneic Human T-Cell Leukemia Virus Type 1-Immortalized Cells.
T. Ohashi, S. Hanabuchi, H. Kato, Y. Koya, F. Takemura, K. Hirokawa, T. Yoshiki, Y. Tanaka, M. Fujii, and M. Kannagi (1999)
J. Virol. 73, 6031-6040
   Abstract »    Full Text »    PDF »
Human T-Lymphotrophic Viruses and Diseases of Long Latency.
W. A. Blattner (1989)
Ann Intern Med 111, 4-6
   Abstract »    PDF »
Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood donors.
A. Williams, C. Fang, D. Slamon, B. Poiesz, S. Sandler, W. Darr 2nd, G Shulman, E. McGowan, D. Douglas, R. Bowman, et al. (1988)
Science 240, 643-646
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)