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Science 15 May 1987:
Vol. 236. no. 4803, pp. 832 - 834
DOI: 10.1126/science.3576201
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Articles

Science, Vol 236, Issue 4803, 832-834
Copyright © 1987 by American Association for the Advancement of Science

articles

Modulation of memory processing by cholecystokinin: dependence on the vagus nerve

JF Flood, GE Smith, and JE Morley

Allowing mice access to food immediately after an aversive training session enhances memory retention. Cholecystokinin-octapeptide (CCK-8), which is a gastrointestinal hormone released during feeding, also enhances memory retention when administered intraperitoneally. This memory-enhancing effect of CCK-8 is blocked when the vagus nerve is cut, indicating that CCK-8 may produce its effect on memory retention by activating ascending fibers in the vagus nerve. Thus, CCK-8, a peripherally acting peptide, may mediate the memory-enhancing effects of feeding.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of mice lacking the gene for cholecystokinin.
C.-M. Lo, L. C. Samuelson, J. B. Chambers, A. King, J. Heiman, R. J. Jandacek, R. R. Sakai, S. C. Benoit, H. E. Raybould, S. C. Woods, et al. (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R803-R810
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Memories Are Made of This: Recent Advances in Understanding Cognitive Impairments and Dementia.
W. A. Banks and J. E. Morley (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, M314-321
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Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.
A. I Ivanov, V. A Kulchitsky, and A. A Romanovsky (2003)
J. Physiol. 547, 941-949
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Food for thought.
J. E Morley (2001)
Am. J. Clinical Nutrition 74, 567-568
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Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly.
R. J Kaplan, C. E Greenwood, G. Winocur, and T. M. Wolever (2001)
Am. J. Clinical Nutrition 74, 687-693
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Reply to UN Das.
R. J Kaplan, C. E Greenwood, G. Winocur, and T. M. Wolever (2001)
Am. J. Clinical Nutrition 74, 410-411
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Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis.
T. Hosoi, Y. Okuma, and Y. Nomura (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R141-R147
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