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Science 24 April 1987:
Vol. 236. no. 4800, pp. 410 - 416
DOI: 10.1126/science.2882604

Articles

Science, Vol 236, Issue 4800, 410-416
Copyright © 1987 by American Association for the Advancement of Science


articles

Neurogenetic adaptive mechanisms in alcoholism

CR Cloninger

Clinical, genetic, and neuropsychopharmacological studies of developmental factors in alcoholism are providing a better understanding of the neurobiological bases of personality and learning. Studies of the adopted-away children of alcoholics show that the predisposition to initiate alcohol-seeking behavior is genetically different from susceptibility to loss of control after drinking begins. Alcohol-seeking behavior is a special case of exploratory appetitive behavior and involves different neurogenetic processes than do susceptibility to behavioral tolerance and dependence on the antianxiety or sedative effects of alcohol. Three dimensions of personality have been described that may reflect individual differences in brain systems modulating the activation, maintenance, and inhibition of behavioral responses to the effects of alcohol and other environmental stimuli. These personality traits distinguish alcoholics with different patterns of behavioral, neurophysiological, and neuropharmacological responses to alcohol.


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Psychopathological and Behavioral Correlates of Dopaminergic Sensitivity in Alcohol-Dependent Patients.
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Mental Disorders and Homicidal Behavior in Finland.
M. Eronen, P. Hakola, and J. Tiihonen (1996)
Arch Gen Psychiatry 53, 497-501
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Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats.
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J. Neurosci. 16, 3474-3485
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Early-Onset Alcoholics Have Lower Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Levels Than Late-Onset Alcoholics.
M.-L. Fus-Aime, M. J. Eckardt, D. T. George, G. L. Brown, I. Mefford, and M. Linnoila (1996)
Arch Gen Psychiatry 53, 211-216
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The Effects of Alcohol Consumption on Laboratory-Induced Panic and State Anxiety.
M. G. Kushner, T. B. Mackenzie, J. Fiszdon, D. P. Valentiner, E. Foa, N. Anderson, and D. Wangensteen (1996)
Arch Gen Psychiatry 53, 264-270
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Specificity of Ethanollike Effects Elicited by Serotonergic and Noradrenergic Mechanisms.
J. H. Krystal, E. Webb, N. Cooney, H. R. Kranzler, and D. S. Charney (1994)
Arch Gen Psychiatry 51, 898-911
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Predicting Early Onset of Male Antisocial Behavior From Preschool Behavior.
R. E. Tremblay, R. O. Pihl, F. Vitaro, and P. L. Dobkin (1994)
Arch Gen Psychiatry 51, 732-739
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A Psychobiological Model of Temperament and Character.
C. R. Cloninger, D. M. Svrakic, and T. R. Przybeck (1993)
Arch Gen Psychiatry 50, 975-990
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Criminality Associated With Mental Disorders and Intellectual Deficiency.
J. Tiihonen, M. Eronen, and P. Hakola (1993)
Arch Gen Psychiatry 50, 917-918
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Progress in Psychiatry- Second of Two Parts.
R. Michels and P. M. Marzuk (1993)
N. Engl. J. Med. 329, 628-638
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Paternal and Maternal Genetic and Environmental Contributions to Cerebrospinal Fluid MonoamineMetabolites in Rhesus Monkeys (Macaca mulatta).
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Arch Gen Psychiatry 50, 615-623
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Low Serum Cholesterol Levels and Morning Suicide.
E. H. Friedman (1993)
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A Twin Study of Genetic and Environmental Contributions to Liability for Posttraumatic Stress Symptoms.
W. R. True, J. Rice, S. A. Eisen, A. C. Heath, J. Goldberg, M. J. Lyons, and J. Nowak (1993)
Arch Gen Psychiatry 50, 257-264
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Nicotine Dependence and Major Depression: New Evidence From a Prospective Investigation.
N. Breslau, M. M. Kilbey, and P. Andreski (1993)
Arch Gen Psychiatry 50, 31-35
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Genetic Vulnerability to Drug Abuse: The D2 Dopamine Receptor Taq I B1 Restriction Fragment Length Polymorphism Appears More Frequently in Polysubstance Abusers.
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The Definition of Alcoholism.
R. M. Morse and D. K. Flavin (1992)
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T. F. Babor, M. Hofmann, F. K. DelBoca, V. Hesselbrock, R. E. Meyer, Z. S. Dolinsky, and B. Rounsaville (1992)
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Types of Alcoholics, II: Application of an Empirically Derived Typology to Treatment Matching.
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Arch Gen Psychiatry 49, 609-614
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Current Excitement With D2 Dopamine Receptor Gene Alleles in Substance Abuse.
G. R. Uhl, A. M. Persico, and S. S. Smith (1992)
Arch Gen Psychiatry 49, 157-160
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Nicotine Dependence, Major Depression, and Anxiety in Young Adults.
N. Breslau, M. M. Kilbey, and P. Andreski (1991)
Arch Gen Psychiatry 48, 1069-1074
   Abstract »    PDF »
NO Association Between an Allele at the D2 Dopamine Receptor Gene (DRD2) and Alcoholism.
J. Gelernter, S. O'Malley, N. Risch, H. R. Kranzler, J. Krystal, K. Merikangas, J. L. Kennedy, and K. K. Kidd (1991)
JAMA 266, 1801-1807
   Abstract »    PDF »
D2 Dopamine Receptor Gene Is Associated but Not Linked With Alcoholism.
C. R. Cloninger (1991)
JAMA 266, 1833-1834
   Abstract »    PDF »
Alcoholism and Alleles of the Human D2 Dopamine Receptor Locus: Studies of Association and Linkage.
A. Parsian, R. D. Todd, E. J. Devor, K. L. O'Malley, B. K. Suarez, T. Reich, and C. R. Cloninger (1991)
Arch Gen Psychiatry 48, 655-663
   Abstract »    PDF »
Mental Disorders Among Alcoholics: Relationship to Age of Onset and Cerebrospinal Fluid Neuropeptides.
A. Roy, J. DeJong, D. Lamparski, B. Adinoff, T. George, V. Moore, D. Garnett, M. Kerich, and M. Linnoila (1991)
Arch Gen Psychiatry 48, 423-427
   Abstract »    PDF »
Personality and Cerebrospinal Fluid Monoamine Metabolites in Alcoholics and Controls.
R. Limson, D. Goldman, A. Roy, D. Lamparski, B. Ravitz, B. Adinoff, and M. Linnoila (1991)
Arch Gen Psychiatry 48, 437-441
   Abstract »    PDF »
Screening for Alcoholism by Life-style Risk Assessment in a Community Hospital.
A. W. Graham (1991)
Arch Intern Med 151, 958-964
   Abstract »    PDF »
Identifying genes determining trait differences in behavior and drug response: a comment on 'Quantitative trait loci and psychopharmacology'.
D. Goldman and M. R. Filling-Katz (1991)
J Psychopharmacol 5, 11-17
   Abstract »    PDF »
Alcohol and the Heart: The Long-term Effects of Alcohol on the Cardiovascular System.
B. Moushmoush and P. Abi-Mansour (1991)
Arch Intern Med 151, 36-42
   Abstract »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)