Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 17 April 1987:
Vol. 236. no. 4799, pp. 271 - 280
DOI: 10.1126/science.3563506
Prev | Table of Contents | Next

Articles

Science, Vol 236, Issue 4799, 271-280
Copyright © 1987 by American Association for the Advancement of Science

articles

Ranking possible carcinogenic hazards

BN Ames, R Magaw, and LS Gold

This review discusses reasons why animal cancer tests cannot be used to predict absolute human risks. Such tests, however, may be used to indicate that some chemicals might be of greater concern than others. Possible hazards to humans from a variety of rodent carcinogens are ranked by an index that relates the potency of each carcinogen in rodents to the exposure in humans. This ranking suggests that carcinogenic hazards from current levels of pesticide residues or water pollution are likely to be of minimal concern relative to the background levels of natural substances, though one cannot say whether these natural exposures are likely to be of major or minor importance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Against Beck: In Defence of Risk Analysis.
S. Campbell and G. Currie (2006)
Philosophy of the Social Sciences 36, 149-172
   Abstract »    PDF »
Electronic Rulemaking: A Public Participation Research Agenda for the Social Sciences.
S. W. Shulman, D. Schlosberg, S. Zavestoski, and D. Courard-Hauri (2003)
Social Science Computer Review 21, 162-178
   Abstract »    PDF »
An Enthusiasm for Metabolism.
B. N. Ames (2003)
J. Biol. Chem. 278, 4369-4380
   Full Text »    PDF »
HOW MUCH DOES THE ENVIRONMENT CONTRIBUTE TO CANCER?.
L. Rushton (2003)
Occup. Environ. Med. 60, 150-156
   Full Text »    PDF »
How can we prevent cancer?.
C. M. Croce (2001)
PNAS 98, 10986-10988
   Full Text »    PDF »
Chemoprevention: Increased potential to bear fruit.
C. R. Wolf (2001)
PNAS 98, 2941-2943
   Full Text »    PDF »
Alleged misconceptions' distort perceptions of environmental cancer risks.
L. TOMATIS, R. L. MELNICK, J. HASEMAN, J. C. BARRETT, and J. HUFF (2001)
FASEB J 15, 195-203
   Abstract »    Full Text »    PDF »
The Antimicrobial Treatment of Periodontal Disease: Changing the Treatment Paradigm.
W.J. Loesche (1999)
Critical Reviews in Oral Biology & Medicine 10, 245-275
   Abstract »    Full Text »    PDF »
Carcinogens in food: priorities for regulatory action.
A. McDonald, R. Fielder, G. Diggle, D. Tennant, and C. Fisher (1996)
Human and Experimental Toxicology 15, 739-746
   Abstract »    PDF »
Does Lowering Cholesterol Cause Cancer?.
J. E. Dalen and W. S. Dalton (1996)
JAMA 275, 67-69
   Abstract »    PDF »
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
W. Orr and R. Sohal (1994)
Science 263, 1128-1130
   Abstract »    PDF »
Rodent carcinogens: setting priorities.
L. Gold, T. Slone, B. Stern, N. Manley, and B. Ames (1992)
Science 258, 261-265
   Abstract »    PDF »
Appraising the Evidence.
A. Wildavsky (1992)
Science 257, 728-729
   PDF »
A critical theoretic look at technical risk analysis.
T. Webler, H. Rakel, and R. J. S. Ross (1992)
Organization Environment 6, 23-38
   Abstract »    PDF »
A Balanced Approach To Risk Assessment.
D. G. Hoel (1991)
Toxicology and Industrial Health 7, 305-311
   PDF »
The Environment and the Lung: Changing Perspectives.
J. M. Samet and M. J. Utell (1991)
JAMA 266, 670-675
   Abstract »    PDF »
Response.
B. N. AMES and L. S. GOLD (1991)
Science 251, 607-608
   PDF »
In Reply: Carcinogens and Human Health: Part 1.
B. N. Ames and L. S. Gold (1990)
Science 250, 1645-1646
   PDF »
Too many rodent carcinogens: mitogenesis increases mutagenesis.
B. Ames and L. Gold (1990)
Science 249, 970-971
   PDF »
Risk within reason.
R. Zeckhauser and W. Viscusi (1990)
Science 248, 559-564
   Abstract »    PDF »
The Maximum Tolerated Dose: The Debate.
E. E. Mcconnell (1989)
International Journal of Toxicology 8, 1115-1120
   PDF »
The rat as an experimental animal.
T. Gill 3rd, G. Smith, R. Wissler, and H. Kunz (1989)
Science 245, 269-276
   Abstract »    PDF »
Carcinogenicity of Chemicals: The Weight of Evidence.
R.L. Carter (1988)
Human and Experimental Toxicology 7, 411-418
   Abstract »    PDF »
The Risk of Polychlorinated Dibenzodioxins in Human Milk.
J. E. Bartmess (1988)
J Hum Lact 4, 105-107
   Abstract »    PDF »
Cancer Risk of Pesticides in Agricultural Workers.
Council on Scientific Affairs (1988)
JAMA 260, 959-966
   Abstract »    PDF »
In Reply: Carcinogenic Risk Estimation.
B. N. Ames and L. S. Gold (1988)
Science 240, 1045-1047
   PDF »
Evolving legal standards for the admissibility of scientific evidence.
B Black (1988)
Science 239, 1508-1512
   Abstract »    PDF »
Paleolithic diet, evolution, and carcinogens.
D. Davis (1987)
Science 238, 1633-1634
   PDF »
Risk assessment and comparisons: an introduction.
R Wilson and E. Crouch (1987)
Science 236, 267-270
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)