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Science 3 April 1987:
Vol. 236. no. 4797, pp. 81 - 83
DOI: 10.1126/science.3105057
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Articles

Science, Vol 236, Issue 4797, 81-83
Copyright © 1987 by American Association for the Advancement of Science

articles

Rheumatoid factor secretion from human Leu-1+ B cells

RR Hardy, K Hayakawa, M Shimizu, K Yamasaki, and T Kishimoto

A human B cell subpopulation identifiable by the expression of the cell surface antigen Leu-1 (CD5) is responsible for most of the immunoglobulin M rheumatoid factor secreted in vitro after the cells are stimulated with Staphylococcus aureus. The ability of B cells bearing the Leu-1 marker (Leu-1+) to secrete rheumatoid factor is present early in development and extends to adulthood, since Leu-1+ B cells from cord blood and from peripheral blood lymphocytes of both normal adults and patients with certain autoimmune conditions secrete rheumatoid factor in comparable amounts. The neonatal enrichment of Leu-1+ B cells, the presence of Leu-1+ B cells in increased frequencies in patients with autoimmune disease, and the involvement of Leu-1+ B cells in autoantibody secretion suggest both developmental and functional homologies between this human B cell subpopulation and the murine Ly-1 B cell subpopulation.


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