Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 March 1987:
Vol. 235. no. 4794, pp. 1390 - 1392
DOI: 10.1126/science.2950593
Prev | Table of Contents | Next

Articles

Science, Vol 235, Issue 4794, 1390-1392
Copyright © 1987 by American Association for the Advancement of Science

articles

Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome

JM Delabar, D Goldgaber, Y Lamour, A Nicole, JL Huret, J de Grouchy, P Brown, DC Gajdusek, and PM Sinet

With the recently cloned complementary DNA probe, lambda Am4 for the chromosome 21 gene encoding brain amyloid polypeptide (beta amyloid protein) of Alzheimer's disease, leukocyte DNA from three patients with sporadic Alzheimer's disease and two patients with karyotypically normal Down syndrome was found to contain three copies of this gene. Because a small region of chromosome 21 containing the ets-2 gene is duplicated in patients with Alzheimer's disease, as well as in karyotypically normal Down syndrome, duplication of a subsection of the critical segment of chromosome 21 that is duplicated in Down syndrome may be the genetic defect in Alzheimer's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident.
P. Altmann, J. Cunningham, U. Dhanesha, M. Ballard, J. Thompson, and F. Marsh (1999)
BMJ 319, 807-811
   Abstract »    Full Text »
Association of Decreased Paternal Age and Late-Onset Alzheimer's Disease: An Example of Genetic Imprinting?.
L. A. Farrer, L. A. Cupples, L. Connor, P. A. Wolf, and J. H. Growdon (1991)
Arch Neurol 48, 599-604
   Abstract »    PDF »
Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships.
H. C. Chui (1989)
Arch Neurol 46, 806-814
   Abstract »    PDF »
The Molecular Genetic Revolution: Its Impact on Clinical Neurology.
C. S. Payne and A. D. Roses (1988)
Arch Neurol 45, 1366-1376
   Abstract »    PDF »
Alzheimer Disease: Clinical and Biological Heterogeneity.
R. P. Friedland, E. Koss, J. V. Haxby, C. L. Grady, J. Luxenberg, M. B. Schapiro, and J. Kaye (1988)
Ann Intern Med 109, 298-311
   Abstract »    PDF »
Molecular and Genetic Investigations on Alzheimer Brain Amyloid.
R. E. Majocha and C. A. Marotta (1988)
J Geriatr Psychiatry Neurol 1, 65-70
   Abstract »    PDF »
Molecular genetics: applications to the clinical neurosciences.
J. Martin (1987)
Science 238, 765-772
   Abstract »    PDF »
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
P. St George-Hyslop, R. Tanzi, R. Polinsky, R. Neve, D Pollen, D Drachman, J Growdon, L. Cupples, L Nee, R. Myers, et al. (1987)
Science 238, 664-666
   Abstract »    PDF »
The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.
R. Tanzi, E. Bird, S. Latt, and R. Neve (1987)
Science 238, 666-669
   Abstract »    PDF »
Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.
M. Podlisny, G Lee, and D. Selkoe (1987)
Science 238, 669-671
   Abstract »    PDF »
Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.
S Bahmanyar, G. Higgins, D Goldgaber, D. Lewis, J. Morrison, M. Wilson, S. Shankar, and D. Gajdusek (1987)
Science 237, 77-80
   Abstract »    PDF »
Using Molecular Probes In The Study Of Alzheimer's Disease.
F. M. Sinex (1987)
American Journal of Alzheimer's Disease and Other Dementias 2, 5-8
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)