Science 13 March 1987: Vol. 235. no. 4794, pp. 1348 - 1352 DOI: 10.1126/science.3029867

Prev | Table of Contents | Next

Articles

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes.

T. Ito, K.-i. Kawahara, K. Okamoto, S. Yamada, M. Yasuda, H. Imaizumi, Y. Nawa, X. Meng, B. Shrestha, T. Hashiguchi, et al. (2008)
Arterioscler Thromb Vasc Biol 28, 1825-1830
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-Specific Hemostasis in Mice.

N. Mackman (2005)
Arterioscler Thromb Vasc Biol 25, 2273-2281
 |  Abstract »  |  Full Text »  |  PDF »

Protein C and/or S deficiency presenting as peripheral arterial insufficiency.

Y P Cho, T-W Kwon, J-H Ahn, G H Kang, M S Han, Y H Kim, J H Kwak, and S G Lee (2005)
Br. J. Radiol. 78, 601-605
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structure of Anticoagulant Thrombin Variant E217K Provides Insights into Thrombin Allostery.

W. J. Carter, T. Myles, C. S. Gibbs, L. L. Leung, and J. A. Huntington (2004)
J. Biol. Chem. 279, 26387-26394
 |  Abstract »  |  Full Text »  |  PDF »

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.

A. W. Rijneveld, S. Weijer, S. Florquin, C. T. Esmon, J. C. M. Meijers, P. Speelman, P. H. Reitsma, H. Ten Cate, and T. van der Poll (2004)
Blood 103, 1702-1709
 |  Abstract »  |  Full Text »  |  PDF »

Effect of activated protein C on plasma plasminogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase: Comparison with unfractionated heparin.

T. Sakamoto, H. Ogawa, K. Takazoe, M. Yoshimura, H. Shimomura, Y. Moriyama, H. Arai, and K. Okajima (2003)
J. Am. Coll. Cardiol. 42, 1389-1394
 |  Abstract »  |  Full Text »  |  PDF »

Infections and endothelial cells.

T. T Keller, A. T.A Mairuhu, M. D de Kruif, S. K Klein, V. E.A Gerdes, H. ten Cate, D. P.M Brandjes, M. Levi, and E. C.M van Gorp (2003)
Cardiovasc Res 60, 40-48
 |  Abstract »  |  Full Text »  |  PDF »

The Potential Role of Direct Thrombin Inhibitors in the Prevention and Treatment of Venous Thromboembolism.

J. A. Heit (2003)
Chest 124 , 40S-48S
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Low Specificity and Cofactor Interaction Sites on Thrombin during Factor XIII Activation: COMPETITION FOR COFACTOR SITES ON THROMBIN DETERMINES ITS FATE.

H. Philippou, J. Rance, T. Myles, S. W. Hall, R. A. Ariens, P. J. Grant, L. Leung, and D. A. Lane (2003)
J. Biol. Chem. 278, 32020-32026
 |  Abstract »  |  Full Text »  |  PDF »

Expression and function of the endothelial protein C receptor in human neutrophils.

D. H. Sturn, N. C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C. J. Wiedermann (2003)
Blood 102, 1499-1505
 |  Abstract »  |  Full Text »  |  PDF »

Deep venous thrombosis associated with protein C and/or S deficiency: management with catheter-directed thrombolysis.

Y P Cho, H J Jang, D H Lee, J Ahn, M S Han, J S Kim, Y H Kim, and S G Lee (2003)
Br. J. Radiol. 76, 380-384
 |  Abstract »  |  Full Text »  |  PDF »

Thrombin and Vascular Development: A Sticky Subject.

M. Moser and C. Patterson (2003)
Arterioscler Thromb Vasc Biol 23, 922-930
 |  Abstract »  |  Full Text »  |  PDF »

Increased Plasma Thrombin-Activatable Fibrinolysis Inhibitor Levels in Normotensive Type 2 Diabetic Patients with Microalbuminuria.

Y. Yano, N. Kitagawa, E. C. Gabazza, K. Morioka, H. Urakawa, T. Tanaka, A. Katsuki, R. Araki-Sasaki, Y. Hori, K. Nakatani, et al. (2003)
J. Clin. Endocrinol. Metab. 88, 736-741
 |  Abstract »  |  Full Text »  |  PDF »

Extrahepatic Synthesis of Factor VII in Human Atherosclerotic Vessels.

J. N. Wilcox, S. Noguchi, and J. Casanova (2003)
Arterioscler Thromb Vasc Biol 23, 136-141
 |  Abstract »  |  Full Text »  |  PDF »

Factor V: a combination of Dr Jekyll and Mr Hyde.

K. G. Mann and M. Kalafatis (2003)
Blood 101, 20-30
 |  Full Text »  |  PDF »

Peripheral arterial insufficiency associated with protein C deficiency.

Y P Cho, D H Lee, H J Jang, J S Kim, M S Han, and S G Lee (2002)
Br. J. Radiol. 75, 843-846
 |  Abstract »  |  Full Text »  |  PDF »

Rho-GTPase-Dependent Platelet-Neutrophil Interaction Affected by HMG-CoA Reductase Inhibition With Altered Adenosine Nucleotide Release and Function.

N. C. Kaneider, P. Egger, S. Dunzendorfer, and C. J. Wiedermann (2002)
Arterioscler Thromb Vasc Biol 22, 1029-1035
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Resistance Is Associated with Increased Circulating Level of Thrombin-Activatable Fibrinolysis Inhibitor in Type 2 Diabetic Patients.

Y. Hori, E. C. Gabazza, Y. Yano, A. Katsuki, K. Suzuki, Y. Adachi, and Y. Sumida (2002)
J. Clin. Endocrinol. Metab. 87, 660-665
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral-Mediated Transfer of Tissue Plasminogen Activator Gene into Brain Capillary Endothelial Cells In Vitro.

J. Ai Kim, C. C. Hedrick, Dangci Xie, and M. J. Fisher (2001)
Angiology 52, 627-634
 |  Abstract »  |  PDF »

Intratracheal Administration of Activated Protein C Inhibits Bleomycin-induced Lung Fibrosis in the Mouse.

H. YASUI, E. C. GABAZZA, S. TAMAKI, T. KOBAYASHI, O. HATAJI, H. YUDA, S. SHIMIZU, K. SUZUKI, Y. ADACHI, and O. TAGUCHI (2001)
Am. J. Respir. Crit. Care Med. 163, 1660-1668
 |  Abstract »  |  Full Text »  |  PDF »

Adrenomedullin Inhibits Angiotensin II-Induced Expression of Tissue Factor and Plasminogen Activator Inhibitor-1 in Cultured Rat Aortic Endothelial Cells.

T. Sugano, H. Tsuji, H. Masuda, H. Nishimura, M. Yoshizumi, H. Kawano, S. Kimura, N. Ukimura, S. Yano, Y. Kunieda, et al. (2001)
Arterioscler Thromb Vasc Biol 21, 1078-1083
 |  Abstract »  |  Full Text »  |  PDF »

arboxypeptidase U at the Interface Between Coagulation and Fibrinolysis.

K. Schatteman, F. Goossens, J. Leurs, R. Verkerk, S. Scharpe, J. J. Michiels, and D. Hendriks (2001)
Clinical and Applied Thrombosis/Hemostasis 7, 93-101
 |  Abstract »  |  PDF »

Cytokines, Endothelium, and Adhesive Molecules in Pathologic Thrombopoiesis.

V. Cobankara, B. Oran, D. Ozatli, I. C. Haznedaroglu, A. Kosar, Y. Buyukasik, O. Ozcebe, S. Dundar, and S. Kirazli (2001)
Clinical and Applied Thrombosis/Hemostasis 7, 126-130
 |  Abstract »  |  PDF »

Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block.

B Isermann, S. Hendrickson, K Hutley, M Wing, and H Weiler (2001)
Development 128, 827-838
 |  Abstract »  |  PDF »

Pharmacological Profile of Recombinant, Human Activated Protein C (LY203638) in a Canine Model of Coronary Artery Thrombosis.

C. V. Jackson, B. D. Bailey, and T. J. Shetler (2000)
J. Pharmacol. Exp. Ther. 295, 967-971
 |  Abstract »  |  Full Text »

Changes of Hemostatic Molecular Markers After Gynecological Surgery.

K. Noda, H. Wada, N. Yamada, N. Noda, E. C. Gabazza, K. Kumeda, T. Okugawa, K. Yanoh, M. Ito, T. Nakano, et al. (2000)
Clinical and Applied Thrombosis/Hemostasis 6, 197-201
 |  Abstract »  |  PDF »

Decreased Protein C Activation Is Associated With Abnormal Collagen Turnover in the Intraalveolar Space of Patients With Interstitial Lung Disease.

H. Yasui, E. C. Gabazza, O. Taguchi, J. Risteli, L. Risteli, H. Wada, H. Yuda, T. Kobayashi, H. Kobayashi, K. Suzuki, et al. (2000)
Clinical and Applied Thrombosis/Hemostasis 6, 202-205
 |  Abstract »  |  PDF »

Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells.

Y. Kawashima, T. Nagasawa, and H. Ninomiya (2000)
Blood 96, 2157-2162
 |  Abstract »  |  Full Text »  |  PDF »

Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients.

C. Giusti, R. Schiaffini, C. Brufani, A. Pantaleo, E. M. Vingolo, and P. Gargiulo (2000)
Br J Ophthalmol 84, 591-595
 |  Abstract »  |  Full Text »

Role of Activated Protein C in Helicobacter pylori-Associated Gastritis.

S. Oka, E. C. Gabazza, Y. Taguchi, M. Yamaguchi, S. Nakashima, K. Suzuki, Y. Adachi, and I. Imoto (2000)
Infect. Immun. 68, 2863-2869
 |  Abstract »  |  Full Text »  |  PDF »

Hemostatic Abnormalities in Patients With Thrombotic Complications on Maintenance Hemodialysis.

A. Inoue, H. Wada, M. Takagi, M. Yamamuro, K. Mukai, T. Nakasaki, M. Shimura, K. Hiyoyama, H. Deguchi, E. C. Gabazza, et al. (2000)
Clinical and Applied Thrombosis/Hemostasis 6, 100-103
 |  Abstract »  |  PDF »

Thrombomodulin as a New Marker of Lesion-Induced Astrogliosis: Involvement of Thrombin through the G-Protein-Coupled Protease-Activated Receptor-1.

A. Pindon, M. Berry, and D. Hantai (2000)
J. Neurosci. 20, 2543-2550
 |  Abstract »  |  Full Text »  |  PDF »

Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S.

M. Makris, M. Leach, N. J. Beauchamp, M. E. Daly, P. C. Cooper, K. K. Hampton, P. Bayliss, I. R. Peake, G. J. Miller, and F. E. Preston (2000)
Blood 95, 1935-1941
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of a thrombomodulin gene mutation coding for an elongated protein with reduced expression in a kindred with myocardial infarction.

G. Kunz, H. A. Ireland, P. J. Stubbs, M. Kahan, G. C. Coulton, and D. A. Lane (2000)
Blood 95, 569-576
 |  Abstract »  |  Full Text »  |  PDF »

Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription.

E. M. Boyle Jr, T. G. Canty Jr, E. N. Morgan, W. Yun, T. H. Pohlman, and E. D. Verrier (1999)
Ann. Thorac. Surg. 68, 1949-1953
 |  Abstract »  |  Full Text »  |  PDF »

Chemokines in Lung Injury: Thomas A. Neff Lecture.

R. M. Strieter, S. L. Kunkel, M. P. Keane, and T. J. Standiford (1999)
Chest 116 , 103S-110S
 |  Full Text »

State-of-the-Art Review : Increased Activated Protein C: Protein C Inhibitor Complex and Decreased Protein C Inhibitor Levels in Patients with Chronic Renal Failure on Maintenance Hemodialysis.

M. Takagi, H. Wada, K. Mukai, K. Minamikawa, Y. Wakita, K. Deguchi, N. Junji, T. Hayashi, K. Suzuki, and H. Shiku (1999)
Clinical and Applied Thrombosis/Hemostasis 5, 113-116
 |  Abstract »  |  PDF »

Extrahepatic Expression and Regulation of Protein C in the Mouse.

K. Yamamoto and D. J. Loskutoff (1998)
Am. J. Pathol. 153, 547-555
 |  Abstract »  |  Full Text »  |  PDF »

The C-terminal Region of the Factor V B-domain Is Crucial for the Anticoagulant Activity of Factor V.

E. Thorelli, R. J. Kaufman, and B. Dahlback (1998)
J. Biol. Chem. 273, 16140-16145
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Activation of Protein C by Factor Xa and Thrombin in the Presence of Polyanionic Compounds.

A. R. Rezaie (1998)
Blood 91, 4572-4580
 |  Abstract »  |  Full Text »  |  PDF »

Protein C Anticoagulant System in Patients with Interstitial Lung Disease.

H. KOBAYASHI, E. C. GABAZZA, O. TAGUCHI, H. WADA, H. TAKEYA, J. NISHIOKA, H. YASUI, T. KOBAYASHI, O. HATAJI, K. SUZUKI, et al. (1998)
Am. J. Respir. Crit. Care Med. 157, 1850-1854
 |  Abstract »  |  Full Text »  |  PDF »

Monoclonal Anti-Cardiolipin Antibodies from New Zealand Black x New Zealand White F1 Mice React to Thrombomodulin.

K. Haruta, S. Kobayashi, S. Hirose, A. Horiai, M. Ohyanagi, M. Tanaka, T. Kawano, T. Shirai, Y. Takasaki, and H. Hashimoto (1998)
J. Immunol. 160, 253-258
 |  Abstract »  |  Full Text »  |  PDF »

Circulating Activated Endothelial Cells in Sickle Cell Anemia.

A. Solovey, Y. Lin, P. Browne, S. Choong, E. Wayner, and R. P. Hebbel (1997)
N. Engl. J. Med. 337, 1584-1590
 |  Abstract »  |  Full Text »  |  PDF »

Intrinsic Anticoagulation: Protein C, Protein S, and Thrombomodulin.

J. L. Mac Hale, N. Nathan, and M. D'Ambra (1997)
Seminars in Cardiothoracic and Vascular Anesthesia 1, 319-332
 |  Abstract »  |  PDF »

Protein C Activation and Factor Va Inactivation on Human Umbilical Vein Endothelial Cells.

M. F. Hockin, M. Kalafatis, M. Shatos, and K. G. Mann (1997)
Arterioscler Thromb Vasc Biol 17, 2765-2775
 |  Abstract »  |  Full Text »

Thrombomodulin Expression in Bovine Brain Capillaries : Anticoagulant Function of the Blood-Brain Barrier, Regional Differences, and Regulatory Mechanisms.

L. Wang, N. D. Tran, M. Kittaka, M. J. Fisher, S. S. Schreiber, and B. V. Zlokovic (1997)
Arterioscler Thromb Vasc Biol 17, 3139-3146
 |  Abstract »  |  Full Text »

Thrombomodulin Gene Mutations Associated With Myocardial Infarction.

H. Ireland, G. Kunz, K. Kyriakoulis, P. J. Stubbs, and D. A. Lane (1997)
Circulation 96, 15-18
 |  Abstract »  |  Full Text »

Functional Requirements for Inhibition of Thrombin by Antithrombin III in the Presence and Absence of Heparin.

M. Tsiang, A. K. Jain, and C. S. Gibbs (1997)
J. Biol. Chem. 272, 12024-12029
 |  Abstract »  |  Full Text »  |  PDF »

Factor VLeiden and Thrombophilia.

M. Kalafatis and K. G. Mann (1997)
Arterioscler Thromb Vasc Biol 17, 620-627
 |  Full Text »

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis.

A. Zivelin, J. H. Griffin, X. Xu, I. Pabinger, M. Samama, J. Conard, B. Brenner, A. Eldor, and U. Seligsohn (1997)
Blood 89, 397-402
 |  Abstract »  |  Full Text »  |  PDF »

The Amino Terminal Lectin-Like Domain of Thrombomodulin Is Required for Constitutive Endocytosis.

E. M. Conway, S. Pollefeyt, D. Collen, and M. Steiner-Mosonyi (1997)
Blood 89, 652-661
 |  Abstract »  |  Full Text »  |  PDF »

Complement C5b-9 Increases Plasminogen Binding and Activation on Human Endothelial Cells.

V. J. Christiansen, P. J. Sims, and K. K. Hamilton (1997)
Arterioscler Thromb Vasc Biol 17, 164-171
 |  Abstract »  |  Full Text »

Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos.

H Weiler-Guettler, W. Aird, H Rayburn, M Husain, and R. Rosenberg (1996)
Development 122, 2271-2281
 |  Abstract »  |  PDF »

Magnesium(II) Is a Crucial Constituent of the Blood Coagulation Cascade.

F. Sekiya, M. Yoshida, T. Yamashita, and T. Morita (1996)
J. Biol. Chem. 271, 8541-8544
 |  Abstract »  |  Full Text »  |  PDF »

Oxidized Low Density Lipoprotein Reduces Thrombomodulin Transcription in Cultured Human Endothelial Cells through Degradation of the Lipoprotein in Lysosomes.

H. Ishii, K. Kizaki, S. Horie, and M. Kazama (1996)
J. Biol. Chem. 271, 8458-8465
 |  Abstract »  |  Full Text »  |  PDF »

Antiphospholipid antibodies and thrombosis: assessment of the potential risk for thrombosis.

H. Salem (1996)
Lupus 5, 163-166
 |  PDF »

Coexistence of Hereditary Homocystinuria and Factor V Leiden -- Effect on Thrombosis.

H. Mandel, B. Brenner, M. Berant, N. Rosenberg, N. Lanir, C. Jakobs, B. Fowler, and U. Seligsohn (1996)
N. Engl. J. Med. 334, 763-768
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced In Vivo Antithrombotic Effects of Endothelial Cells Expressing Recombinant Plasminogen Activators Transduced With Retroviral Vectors.

D. A. Dichek, J. Anderson, A. B. Kelly, S. R. Hanson, and L. A. Harker (1996)
Circulation 93, 301-309
 |  Abstract »  |  Full Text »

EFFECTS OF CRYOPRESERVATION ON THE PROLIFERATION AND ANTICOAGULANT ACTIVITY OF HUMAN SAPHENOUS VEIN ENDOTHELIAL CELLS.

L. S. Bambang, J. P. Mazzucotelli, M. Moczar, F. Beaujean, and D. Loisance (1995)
J. Thorac. Cardiovasc. Surg. 110, 998-1004
 |  Abstract »  |  Full Text »

Determinants of Thrombin Receptor Cleavage.

K. Ishii, R. Gerszten, Y. W. Zheng, J. B. Welsh, C. W. Turck, and S. R. Coughlin (1995)
J. Biol. Chem. 270, 16435-16440
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of Tissue Factor Expression in Human Endothelial Cells.

G. C. N. Parry and N. Mackman (1995)
Arterioscler Thromb Vasc Biol 15, 612-621
 |  Abstract »  |  Full Text »

Rebound Increase in Thrombin Generation and Activity After Cessation of Intravenous Heparin in Patients With Acute Coronary Syndromes.

C. B. Granger, J. M. Miller, E. G. Bovill, A. Gruber, R. P. Tracy, M. W. Krucoff, C. Green, E. Berrios, R. A. Harrington, E. M. Ohman, et al. (1995)
Circulation 91, 1929-1935
 |  Abstract »  |  Full Text »

The Pathogenesis of Sepsis.

R. C. Bone (1991)
Ann Intern Med 115, 457-469
 |  Abstract »  |  PDF »

Background Review and Current Concepts of Reperfusion Injury.

J. M. Hallenbeck and A. J. Dutka (1990)
Arch Neurol 47, 1245-1254
 |  Abstract »  |  PDF »

Altered Coagulation in Cerebral Ischemia Platelet, Thrombin, and Plasmin Activity.

M. Fisher and R. Francis (1990)
Arch Neurol 47, 1075-1079
 |  Abstract »  |  PDF »

Recombinant gene expression in vivo within endothelial cells of the arterial wall.

E. Nabel, G Plautz, F. Boyce, J. Stanley, and G. Nabel (1989)
Science 244, 1342-1344
 |  Abstract »  |  PDF »

Heparin promotes the inactivation of antithrombin by neutrophil elastase.

R. Jordan, J Kilpatrick, and R. Nelson (1987)
Science 237, 777-779
 |  Abstract »  |  PDF »

To Advertise   |   Find Products