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Science 6 March 1987:
Vol. 235. no. 4793, pp. 1218 - 1221
DOI: 10.1126/science.3547648
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Articles

Science, Vol 235, Issue 4793, 1218-1221
Copyright © 1987 by American Association for the Advancement of Science

articles

CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae

LC Robinson, JB Gibbs, MS Marshall, IS Sigal, and K Tatchell

The yeast Saccharomyces cerevisiae contains two functional homologues of the ras oncogene family, RAS1 and RAS2. These genes are required for growth, and all evidence indicates that this essential function is the activation of adenylate cyclase. In contrast, ras in mammalian cells does not appear to influence adenylate cyclase activity. To clarify the relation between ras function in yeast and in higher eukaryotes, and the role played by yeast RAS in growth control, it is necessary to identify functions acting upstream of RAS in the adenylate cyclase pathway. The evidence presented here indicates that CDC25, identified by conditional cell cycle arrest mutations, encodes such an upstream function.


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GTP-GDP exchange proteins.
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Studies of RAS Function in the Yeast Saccharomyces cerevisiae.
M. Wigler, J. Field, S. Powers, D. Broek, T. Toda, S. Cameron, J. Nikawa, T. Michaeli, J. Colicelli, and K. Ferguson (1988)
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