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Science 6 March 1987:
Vol. 235. no. 4793, pp. 1211 - 1214
DOI: 10.1126/science.2434998
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Articles

Science, Vol 235, Issue 4793, 1211-1214
Copyright © 1987 by American Association for the Advancement of Science

articles

Cyclic AMP-modulated potassium channels in murine B cells and their precursors

D Choquet, P Sarthou, D Primi, PA Cazenave, and H Korn

A voltage-dependent potassium current (the delayed rectifier) has been found in murine B cells and their precursors with the whole-cell patch-clamp technique. The type of channel involved in the generation of this current appears to be present throughout all stages of pre-B-cell differentiation, since it is detected in pre-B cell lines infected with Abelson murine leukemia virus; these cell lines represent various phases of B-cell development. Thus, the presence of this channel is not obviously correlated with B-cell differentiation. Although blocked by Co2+, the channel, or channels, does not appear to be activated by Ca2+ entry. It is, however, inactivated by high intracellular Ca2+ concentrations. In addition, elevation of intracellular adenosine 3', 5'-monophosphate induces at all potentials a rapid decrease in the peak potassium conductance and increased rates of activation and inactivation. Therefore, potassium channels can be physiologically modulated by second messengers in lymphocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduction in Voltage-Gated K+ Currents in Primary Cultured Rat Pancreatic {beta}-Cells by Linoleic Acids.
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Antagonism of Rat {beta}-Cell Voltage-dependent K+ Currents by Exendin 4 Requires Dual Activation of the cAMP/Protein Kinase A and Phosphatidylinositol 3-Kinase Signaling Pathways.
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The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion.
P. E. MacDonald, W. El-kholy, M. J. Riedel, A. M. F. Salapatek, P. E. Light, and M. B. Wheeler (2002)
Diabetes 51, S434-442
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Comparison of Mouse and Rabbit Ei{kappa} Enhancers Indicates That Different Elements Within the Enhancer May Mediate Activation of Transcription and Recombination.
I. Coquilleau, P. Cavelier, F. Rougeon, and M. Goodhardt (2000)
J. Immunol. 164, 795-804
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Elevation of intracellular Ca2+ in the physiologically relevant range does not inhibit voltage-gated K+ channels in human T lymphocytes.
J. A H Verheugen (1998)
J. Physiol. 508, 167-177
   Abstract »    Full Text »    PDF »
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
T Hoshi, S. Garber, and R. Aldrich (1988)
Science 240, 1652-1655
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Subset-specific expression of potassium channels in developing murine T lymphocytes.
R. Lewis and M. Cahalan (1988)
Science 239, 771-775
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