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Science 27 February 1987:
Vol. 235. no. 4792, pp. 1070 - 1073
DOI: 10.1126/science.2881350
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Articles

Science, Vol 235, Issue 4792, 1070-1073
Copyright © 1987 by American Association for the Advancement of Science

articles

Arginine vasopressin as a thyrotropin-releasing hormone

MD Lumpkin, WK Samson, and SM McCann

Although hypothyroidism (with concomitant increased levels of thyroid-stimulating hormone) has been associated with elevated plasma vasopressin, the role that vasopressin plays in controlling thyroid-stimulating hormone secretion from the adenohypophysis is not understood. In two in vitro pituitary cell systems, vasopressin caused a specific and dose-related release of thyroid-stimulating hormone from cells that was equal in potency to that elicited by thyrotropin-releasing hormone, the primary acknowledged regulator of thyroid-stimulating hormone release. When injected into the hypothalamus, however, vasopressin specifically inhibited the release of thyroid-stimulating hormone. Thus, vasopressin may exert differential regulatory effects on thyroid-stimulating hormone secretion in the hypothalamus and pituitary gland.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ontogeny and Effects of Hypothalamic Pituitary Disconnection on Formation of Inositol Trisphosphate in Fetal Sheep Pituitary Cells.
L. C. Carey, S. B. Tatter, and J. C. Rose (2007)
Endocrinology 148, 1440-1444
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