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Science 20 February 1987:
Vol. 235. no. 4791, pp. 893 - 895
DOI: 10.1126/science.2433770
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Articles

Science, Vol 235, Issue 4791, 893-895
Copyright © 1987 by American Association for the Advancement of Science

articles

Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis

M Lotz, DA Carson, and JH Vaughan

Several clinical features are consistent with nervous system involvement in the pathogenesis of rheumatoid arthritis. The neuropeptide substance P is one possible mediator of this interaction, since it can be released into joint tissues from primary sensory nerve fibers. The potential effects of the peptide on rheumatoid synoviocytes were examined. The results show that substance P stimulates prostaglandin E2 and collagenase release from synoviocytes. Furthermore, synoviocyte proliferation was increased in the presence of the neuropeptide. Similar effects were observed with a truncated form of substance P. Synoviocytes were sensitive to very small doses of the neuropeptide (10(-9) M), and its effects were inhibited by a specific antagonist. Thus, the specific stimulation of synoviocytes by the neuropeptide substance P represents a pathway by which the nervous system might be directly involved in the pathogenesis of rheumatoid arthritis.


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