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Science 13 February 1987:
Vol. 235. no. 4790, pp. 790 - 793
DOI: 10.1126/science.3643650
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Articles

Science, Vol 235, Issue 4790, 790-793
Copyright © 1987 by American Association for the Advancement of Science

articles

Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome

NC Pedersen, EW Ho, ML Brown, and JK Yamamoto

A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new virus, whereas 10 of 25 cats with signs of ill health were seropositive for the virus. Tentatively designated feline T-lymphotropic lentivirus, this new feline retrovirus appears to be antigenically distinct from human immunodeficiency virus. There is no evidence for cat-to-human transmission of the agent. Kittens experimentally infected by way of blood or plasma from naturally infected animals developed generalized lymphadenopathy several weeks later, became transiently febrile and leukopenic, and continued to show a generalized lymphadenopathy 5 months after infection.


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J. Virol. 76, 6882-6892
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Evolution of Replication Efficiency following Infection with a Molecularly Cloned Feline Immunodeficiency Virus of Low Virulence.
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J. Virol. 76, 6062-6072
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Early Pathogenesis of Transmucosal Feline Immunodeficiency Virus Infection.
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J. Virol. 76, 6311-6322
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In Vitro and Animal Models of Human Immunodeficiency Virus Infection of the Central Nervous System.
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Feline Immunodeficiency Virus Xenoinfection: the Role of Chemokine Receptors and Envelope Diversity.
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Envelope Gene-Mediated Neurovirulence in Feline Immunodeficiency Virus Infection: Induction of Matrix Metalloproteinases and Neuronal Injury.
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Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma.
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Feline Immunodeficiency Virus Cell Entry.
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J. Virol. 75, 5433-5440
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Binding of Recombinant Feline Immunodeficiency Virus Surface Glycoprotein to Feline Cells: Role of CXCR4, Cell-Surface Heparans, and an Unidentified Non-CXCR4 Receptor.
A. de Parseval and J. H. Elder (2001)
J. Virol. 75, 4528-4539
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AIDS Vaccination Studies Using an Ex Vivo Feline Immunodeficiency Virus Model: Reevaluation of Neutralizing Antibody Levels Elicited by a Protective and a Nonprotective Vaccine after Removal of Antisubstrate Cell Antibodies.
S. Giannecchini, D. Del Mauro, D. Matteucci, and M. Bendinelli (2001)
J. Virol. 75, 4424-4429
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Immunogenicity of an Anti-Clade B Feline Immunodeficiency Fixed-Cell Virus Vaccine in Field Cats.
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J. Virol. 74, 10911-10919
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Antiviral Therapy Reduces Viral Burden but Does Not Prevent Thymic Involution in Young Cats Infected with Feline Immunodeficiency Virus.
K. A. Hayes, A. J. Phipps, S. Francke, and L. E. Mathes (2000)
Antimicrob. Agents Chemother. 44, 2399-2405
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Relationship of Lymphoid Lesions to Disease Course in Mucosal Feline Immunodeficiency Virus Type C Infection.
L. A. Obert and E. A. Hoover (2000)
Vet. Pathol. 37, 386-401
   Abstract »    Full Text »    PDF »
The feline model of neuroAIDS: understanding the progression towards AIDS dementia.
M. Podell, P. A. March, W. R. Buck, and L. E. Mathes (2000)
J Psychopharmacol 14, 205-213
   Abstract »    PDF »
Feline Immunodeficiency Virus Vif Localizes to the Nucleus.
U. Chatterji, C. K. Grant, and J. H. Elder (2000)
J. Virol. 74, 2533-2540
   Abstract »    Full Text »    PDF »
Expanded Host Cell Tropism and Cytopathic Properties of Feline Immunodeficiency Virus Strain PPR Subsequent to Passage through Interleukin-2-Independent T Cells.
D. L. Lerner and J. H. Elder (2000)
J. Virol. 74, 1854-1863
   Abstract »    Full Text »    PDF »
Anti-Feline Immunodeficiency Virus (FIV) Soluble Factor(s) Produced from Antigen-Stimulated Feline CD8+ T Lymphocytes Suppresses FIV Replication.
I.-S. Choi, R. Hokanson, and E. W. Collisson (2000)
J. Virol. 74, 676-683
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Envelope gene sequences encoding variable regions 3 and 4 are involved in macrophage tropism of feline immunodeficiency virus.
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J. Gen. Virol. 80, 2639-2646
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In Vivo Monocyte Tropism of Pathogenic Feline Immunodeficiency Viruses.
S. W. Dow, C. K. Mathiason, and E. A. Hoover (1999)
J. Virol. 73, 6852-6861
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Shared Usage of the Chemokine Receptor CXCR4 by Primary and Laboratory-Adapted Strains of Feline Immunodeficiency Virus.
J. Richardson, G. Pancino, R. Merat, T. Leste-Lasserre, A. Moraillon, J. Schneider-Mergener, M. Alizon, P. Sonigo, and N. Heveker (1999)
J. Virol. 73, 3661-3671
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Differential Cell Tropism of Feline Immunodeficiency Virus Molecular Clones In Vivo.
G. A. Dean, S. Himathongkham, and E. E. Sparger (1999)
J. Virol. 73, 2596-2603
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AIDS Vaccination Studies Using an Ex Vivo Feline Immunodeficiency Virus Model: Detailed Analysis of the Humoral Immune Response to a Protective Vaccine.
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J. Virol. 73, 1-10
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Demonstration that orf2 Encodes the Feline Immunodeficiency Virus Transactivating (Tat) Protein and Characterization of a Unique Gene Product with Partial Rev Activity.
A. de Parseval and J. H. Elder (1999)
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Neurovirulence in Feline Immunodeficiency Virus-Infected Neonatal Cats Is Viral Strain Specific and Dependent on Systemic Immune Suppression.
C. Power, R. Buist, J. B. Johnston, M. R. Del Bigio, W. Ni, M. R. Dawood, and J. Peeling (1998)
J. Virol. 72, 9109-9115
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CXCR4 Is Required by a Nonprimate Lentivirus: Heterologous Expression of Feline Immunodeficiency Virus in Human, Rodent, and Feline Cells.
E. M. Poeschla and D. J. Looney (1998)
J. Virol. 72, 6858-6866
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Modulation of Feline Immunodeficiency Virus Infection by Stromal Cell-Derived Factor.
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J. Virol. 72, 2097-2104
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A Novel Point Mutation at Position 156 of Reverse Transcriptase from Feline Immunodeficiency Virus Confers Resistance to the Combination of (-)-beta -2',3'-Dideoxy-3'-Thiacytidine and 3'-Azido-3'-Deoxythymidine.
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J. Virol. 72, 2335-2340
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Delayed Infection after Immunization with a Peptide from the Transmembrane Glycoprotein of the Feline Immunodeficiency Virus.
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J. Virol. 72, 2406-2415
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Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo.
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PNAS 95, 939-944
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Science 257, 1885-1894
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Development and testing of AIDS vaccines.
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The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
A. Fauci (1988)
Science 239, 617-622
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