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Science 13 February 1987:
Vol. 235. no. 4790, pp. 787 - 789
DOI: 10.1126/science.3810165
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Articles

Science, Vol 235, Issue 4790, 787-789
Copyright © 1987 by American Association for the Advancement of Science

articles

Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis

M Potter, JF Mushinski, EB Mushinski, S Brust, JS Wax, F Wiener, M Babonits, UR Rapp, and HC Morse 3rd

Deregulation of c-myc expression in association with chromosomal translocations occurs in over 95% of murine plasmacytomas, rat immunocytomas, and human Burkitt lymphomas. Infection with a murine retrovirus (J-3) containing an avian v-myc rapidly induced plasmacytomas in pristane-primed BALB/cAn mice. Only 17% of the induced plasmacytomas that were karyotyped showed the characteristic chromosomal translocations involving the c-myc locus. Instead, all of the translocation-negative tumors demonstrated characteristic J-3 virus integration sites that were actively transcribed. Thus, the high levels of v-myc expression have replaced the requirement for chromosomal translocation in plasmacytomagenesis and accelerated the process of transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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S. S. Park, A. L. Shaffer, J. S. Kim, W. duBois, M. Potter, L. M. Staudt, and S. Janz (2005)
Cancer Res. 65, 7644-7652
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Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells.
S. Ohno, J.-i. Hayakawa, N. Hashimoto, and F. Wiener (1999)
Carcinogenesis 20, 529-538
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The approaching era of the tumor suppressor genes.
G Klein (1987)
Science 238, 1539-1545
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