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Science 19 December 1986:
Vol. 234. no. 4783, pp. 1577 - 1580
DOI: 10.1126/science.3787264
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Articles

Science, Vol 234, Issue 4783, 1577-1580
Copyright © 1986 by American Association for the Advancement of Science

articles

Lipid domains in fluid membranes: a quick-freeze differential scanning calorimetry study

DL Melchior

The application of rapid-freezing techniques to differential scanning calorimetry (DSC) provides a new approach for understanding the organization of lipids in biomembranes. Use of quick-freeze DSC on membranes of mixed lipid composition supports the existence of nonrandom distributions of lipids (domains) in fluid bilayers. In addition to allowing investigations on the organization of lipids in fluid bilayers, the quick-freeze technique now allows calorimetric studies to be carried out on mammalian membranes which, because of their high cholesterol content, have not been previously amenable to study by DSC.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alteration of Lipids, G Proteins, and PKC in Cell Membranes of Elderly Hypertensives.
P. V. Escriba, J. M. Sanchez-Dominguez, R. Alemany, J. S. Perona, and V. Ruiz-Gutierrez (2003)
Hypertension 41, 176-182
   Abstract »    Full Text »    PDF »
Quick-freeze lipid techniques: correction.
D. Melchior (1987)
Science 238, 550
   PDF »


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