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Science 19 December 1986:
Vol. 234. no. 4783, pp. 1545 - 1548
DOI: 10.1126/science.3787260
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Articles

Science, Vol 234, Issue 4783, 1545-1548
Copyright © 1986 by American Association for the Advancement of Science

articles

A novel human gene closely related to the abl proto-oncogene

GD Kruh, CR King, MH Kraus, NC Popescu, SC Amsbaugh, WO McBride, and SA Aaronson

A DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to the corresponding sequences of c-abl and v-abl but was related to other tyrosine kinase genes as well. The new sequence was localized by in situ hybridization and somatic cell genetic analysis to human chromosome 1q24-25, which differs from the location of any previously identified tyrosine kinase gene. The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.
Q. L. K. Lam, C. K. C. Lo, B.-J. Zheng, K.-H. Ko, D. G. Osmond, G. E. Wu, R. Rottapel, and L. Lu (2007)
Int. Immunol. 19, 267-276
   Abstract »    Full Text »    PDF »
Glutathione Peroxidase 1 Is Regulated by the c-Abl and Arg Tyrosine Kinases.
C. Cao, Y. Leng, W. Huang, X. Liu, and D. Kufe (2003)
J. Biol. Chem. 278, 39609-39614
   Abstract »    Full Text »    PDF »
Catalase Activity Is Regulated by c-Abl and Arg in the Oxidative Stress Response.
C. Cao, Y. Leng, and D. Kufe (2003)
J. Biol. Chem. 278, 29667-29675
   Abstract »    Full Text »    PDF »
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
P. J. Woodring, T. Hunter, and J. Y. J. Wang (2003)
J. Cell Sci. 116, 2613-2626
   Abstract »    Full Text »    PDF »
Functional Interaction between the c-Abl and Arg Protein-tyrosine Kinases in the Oxidative Stress Response.
C. Cao, Y. Leng, C. Li, and D. Kufe (2003)
J. Biol. Chem. 278, 12961-12967
   Abstract »    Full Text »    PDF »
ARG tyrosine kinase activity is inhibited by STI571.
K. Okuda, E. Weisberg, D. G. Gilliland, and J. D. Griffin (2001)
Blood 97, 2440-2448
   Abstract »    Full Text »    PDF »
A new ETV6 / TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.
Y. Iijima, T. Ito, T. Oikawa, M. Eguchi, M. Eguchi-Ishimae, N. Kamada, K. Kishi, S. Asano, Y. Sakaki, and Y. Sato (2000)
Blood 95, 2126-2131
   Abstract »    Full Text »    PDF »
The Tyrosine Kinase Abl-Related Gene ARG Is Fused to ETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts.
G. Cazzaniga, S. Tosi, A. Aloisi, G. Giudici, M. Daniotti, P. Pioltelli, L. Kearney, and A. Biondi (1999)
Blood 94, 4370-4373
   Abstract »    Full Text »    PDF »
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites..
R Ren, Z S Ye, and D Baltimore (1994)
Genes & Dev. 8, 783-795
   Abstract »    PDF »
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
S. Hanks, A. Quinn, and T Hunter (1988)
Science 241, 42-52
   Abstract »    PDF »
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.
V. Rao, T. Papas, and E. Reddy (1987)
Science 237, 635-639
   Abstract »    PDF »


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