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Science 5 December 1986:
Vol. 234. no. 4781, pp. 1217 - 1223
DOI: 10.1126/science.3775380
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Articles

Science, Vol 234, Issue 4781, 1217-1223
Copyright © 1986 by American Association for the Advancement of Science

articles

The molecular basis of erythrocyte shape

A Elgsaeter, BT Stokke, A Mikkelsen, and D Branton

Recent discoveries about the molecular organization and physical properties of the mammalian erythrocyte membrane and its associated structural proteins can now be used to explain, and may eventually be used to predict, the shape of the erythrocyte. Such explanations are possible because the relatively few structural proteins of the erythrocyte are regularly distributed over the entire cytoplasmic surface of the cell membrane and because the well-understood topological associations of these proteins seem to be stable in comparison with the time required for the cell to change shape. These simplifications make the erythrocyte the first nonmuscle cell for which it will be possible to extend our knowledge of molecular interactions to the next hierarchical level of organization that deals with shape and shape transformations.


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Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis.
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Crystal structure of the repetitive segments of spectrin.
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Synthesis of Two-Dimensional Polymers.
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A new member of the spectrin superfamily may participate in the formation of embryonic muscle attachments in Drosophila.
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Diffraction from Polymerized Membranes.
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