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Science 21 November 1986:
Vol. 234. no. 4779, pp. 985 - 988
DOI: 10.1126/science.3775372
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Articles

Science, Vol 234, Issue 4779, 985-988
Copyright © 1986 by American Association for the Advancement of Science

articles

Long-term potentiation in dentate gyrus: induction by asynchronous volleys in separate afferents

J Winson and D Dahl

Long-term potentiation (LTP), a long-lasting enhancement of synaptic efficacy, is considered a model for learning and memory. In anesthetized rats, activation of dentate granule cells by stimulating either the medial or lateral perforant pathway at frequencies of 100 to 400 Hz produced LTP of the stimulated pathway preferentially at 400 Hz. However, hippocampal pathways do not normally fire at this high rate. Stimuli at 200 Hz were then applied to either the medial or lateral pathway separately, to both pathways simultaneously, or to the two pathways asynchronously so that the composite stimulus applied to the granule cell dendrite was 400 Hz. LTP was produced preferentially in the asynchronous condition. Thus, lower frequency, physiological input volleys arriving asynchronously at medial and lateral synapses can induce LTP by activating a 400-Hz sensitive mechanism capable of integrating spatially separated granule cell inputs. This may reflect how LTP is normally produced in the dentate gyrus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Hippocampal Long-Term Potentiation during Waking Leads to Increased Extrahippocampal zif-268 Expression during Ensuing Rapid-Eye-Movement Sleep.
S. Ribeiro, C. V. Mello, T. Velho, T. J. Gardner, E. D. Jarvis, and C. Pavlides (2002)
J. Neurosci. 22, 10914-10923
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Long-Term Potentiation in the Dentate Gyrus Is Not Linked to Increased Extracellular Glutamate Concentration.
T. M. Jay, E. Zilkha, and T. P. Obrenovitch (1999)
J Neurophysiol 81, 1741-1748
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The influence of prior synaptic activity on the induction of long-term potentiation.
Y. Huang, A Colino, D. Selig, and R. Malenka (1992)
Science 255, 730-733
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The dynamics of free calcium in dendritic spines in response to repetitive synaptic input.
E Gamble and C Koch (1987)
Science 236, 1311-1315
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