Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 November 1986:
Vol. 234. no. 4778, pp. 868 - 870
DOI: 10.1126/science.3775368
Prev | Table of Contents | Next

Articles

Science, Vol 234, Issue 4778, 868-870
Copyright © 1986 by American Association for the Advancement of Science

articles

Flow control among microvessels coordinated by intercellular conduction

SS Segal and BR Duling

Optimal distribution of blood flow requires coordination of vasodilation among resistance vessels. During hyperemia, blood vessels dilate upstream from the initiating stimulus. Spreading vasodilation independent of flow changes has not been previously demonstrated. In the present study, iontophoresis of acetylcholine adjacent to single hamster cheek pouch arterioles in situ (diameter, 20 to 37 micrometers) induced a rapid bidirectional dilation that was not attenuated when blood flow was eliminated with vascular occlusion. This finding indicates that a vasodilatory stimulus is conducted along the arteriole and demonstrates the existence of a mechanism of intercellular communication that is capable of coordinating diameter changes among resistance vessels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural adaptation of microvessel diameters in response to metabolic stimuli: where are the oxygen sensors?.
B. Reglin, T. W. Secomb, and A. R. Pries (2009)
Am J Physiol Heart Circ Physiol 297, H2206-H2219
   Abstract »    Full Text »    PDF »
Mechanistic basis of differential conduction in skeletal muscle arteries.
C. H. T. Tran, E. J. Vigmond, F. Plane, and D. G. Welsh (2009)
J. Physiol. 587, 1301-1318
   Abstract »    Full Text »    PDF »
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans.
A. R. Maher, A. B. Milsom, P. Gunaruwan, K. Abozguia, I. Ahmed, R. A. Weaver, P. Thomas, H. Ashrafian, G. V.R. Born, P. E. James, et al. (2008)
Circulation 117, 670-677
   Abstract »    Full Text »    PDF »
Age-related changes in conducted vasodilation: effects of exercise training and role in functional hyperemia.
S. E. Bearden, E. Linn, B. S. Ashley, and R. C. Looft-Wilson (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R1717-R1721
   Abstract »    Full Text »    PDF »
Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteries.
P. Winter and K. A. Dora (2007)
J. Physiol. 582, 335-347
   Abstract »    Full Text »    PDF »
Postischemic Augmentation of Conducted Dilation in Cerebral Arterioles.
A. C. Ngai, T.-S. Nguyen, J. R. Meno, and G. W. Britz (2007)
Stroke 38, 124-130
   Abstract »    Full Text »    PDF »
Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation.
M. T. Gladwin, N. J. H. Raat, S. Shiva, C. Dezfulian, N. Hogg, D. B. Kim-Shapiro, and R. P. Patel (2006)
Am J Physiol Heart Circ Physiol 291, H2026-H2035
   Abstract »    Full Text »    PDF »
Vascular Gap Junctions in Hypertension.
X. F. Figueroa, B. E. Isakson, and B. R. Duling (2006)
Hypertension 48, 804-811
   Full Text »    PDF »
Cross-talk between cardiac muscle and coronary vasculature..
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema (2006)
Physiol Rev 86, 1263-1308
   Abstract »    Full Text »    PDF »
Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries.
M. C. Jantzi, S. E. Brett, W. F. Jackson, R. Corteling, E. J. Vigmond, and D. G. Welsh (2006)
Am J Physiol Heart Circ Physiol 291, H1319-H1328
   Abstract »    Full Text »    PDF »
Initiation of remote microvascular preconditioning requires KATP channel activity.
L. Mabanta, P. Valane, J. Borne, and M. D. Frame (2006)
Am J Physiol Heart Circ Physiol 290, H264-H271
   Abstract »    Full Text »    PDF »
Defining electrical communication in skeletal muscle resistance arteries: a computational approach.
H. K Diep, E. J Vigmond, S. S Segal, and D. G Welsh (2005)
J. Physiol. 568, 267-281
   Abstract »    Full Text »    PDF »
Remote arteriolar dilations caused by methacholine: a role for CGRP sensory nerves?.
N. Thengchaisri and R. J. Rivers (2005)
Am J Physiol Heart Circ Physiol 289, H608-H613
   Abstract »    Full Text »    PDF »
Hemoglobin as a Nitrite Reductase Regulating Red Cell-Dependent Hypoxic Vasodilation.
M. T. Gladwin (2005)
Am. J. Respir. Cell Mol. Biol. 32, 363-366
   Full Text »    PDF »
Plasma ATP during exercise: possible role in regulation of coronary blood flow.
M. Farias III, M. W. Gorman, M. V. Savage, and E. O. Feigl (2005)
Am J Physiol Heart Circ Physiol 288, H1586-H1590
   Abstract »    Full Text »    PDF »
Hypertension attenuates cell-to-cell communication in hamster retractor muscle feed arteries.
D. T. Kurjiaka, S. B. Bender, D. D. Nye, W. B. Wiehler, and D. G. Welsh (2005)
Am J Physiol Heart Circ Physiol 288, H861-H870
   Abstract »    Full Text »    PDF »
Connexins: Gaps in Our Knowledge of Vascular Function.
X. F. Figueroa, B. E. Isakson, and B. R. Duling (2004)
Physiology 19, 277-284
   Abstract »    Full Text »    PDF »
Connexin expression and conducted vasodilation along arteriolar endothelium in mouse skeletal muscle.
R. C. Looft-Wilson, G. W. Payne, and S. S. Segal (2004)
J Appl Physiol 97, 1152-1158
   Abstract »    Full Text »    PDF »
Prostacyclin Analogue (Beraprost) Relief of Cold Intolerance After Digital Replantation and Revascularization.
N. ISOGAI, Y. MIYASATO, and S. ASAMURA (2004)
J Hand Surg Eur Vol. 29, 406-408
   Abstract »    Full Text »    PDF »
Levels of Gap Junction Proteins in Coronary Arterioles and Aorta of Hamsters Exposed to the Cold and During Hibernation and Arousal.
P. Saitongdee, D. L. Becker, P. Milner, G. E. Knight, and G. Burnstock (2004)
J. Histochem. Cytochem. 52, 603-616
   Abstract »    Full Text »    PDF »
Spreading dilatation in rat mesenteric arteries associated with calcium-independent endothelial cell hyperpolarization.
H. Takano, K. A. Dora, M. M. Spitaler, and C. J. Garland (2004)
J. Physiol. 556, 887-903
   Abstract »    Full Text »    PDF »
Homocellular Conduction Along Endothelium and Smooth Muscle of Arterioles in Hamster Cheek Pouch: Unmasking an NO Wave.
S. Budel, I. S. Bartlett, and S. S. Segal (2003)
Circ. Res. 93, 61-68
   Abstract »    Full Text »    PDF »
Central Role of Connexin40 in the Propagation of Electrically Activated Vasodilation in Mouse Cremasteric Arterioles In Vivo.
X. F. Figueroa, D. L. Paul, A. M. Simon, D. A. Goodenough, K. H. Day, D. N. Damon, and B. R. Duling (2003)
Circ. Res. 92, 793-800
   Abstract »    Full Text »    PDF »
Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion.
C. de Wit, F. Roos, S.-S. Bolz, and U. Pohl (2003)
Physiol Genomics 13, 169-177
   Abstract »    Full Text »    PDF »
EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles.
B. Hoepfl, B. Rodenwaldt, U. Pohl, and C. de Wit (2002)
Am J Physiol Heart Circ Physiol 283, H996-H1004
   Abstract »    Full Text »    PDF »
Role for endothelial cell conduction in ascending vasodilatation and exercise hyperaemia in hamster skeletal muscle.
S. S Segal and T. L Jacobs (2001)
J. Physiol. 536, 937-946
   Abstract »    Full Text »    PDF »
Structural adaptation of microvascular networks: functional roles of adaptive responses.
A. R. Pries, B. Reglin, and T. W. Secomb (2001)
Am J Physiol Heart Circ Physiol 281, H1015-H1025
   Abstract »    Full Text »    PDF »
Conducted vasoconstriction in rat mesenteric arterioles: role for dihydropyridine-insensitive Ca2+ channels.
F. Gustafsson, D. Andreasen, M. Salomonsson, B. L. Jensen, and N.-H. Holstein-Rathlou (2001)
Am J Physiol Heart Circ Physiol 280, H582-H590
   Abstract »    Full Text »    PDF »
Role of EDHF in conduction of vasodilation along hamster cheek pouch arterioles in vivo.
D. G. Welsh and S. S. Segal (2000)
Am J Physiol Heart Circ Physiol 278, H1832-H1839
   Abstract »    Full Text »    PDF »
Remote arteriolar dilations in response to muscle contraction under capillaries.
K. D. Cohen, B. R. Berg, and I. H. Sarelius (2000)
Am J Physiol Heart Circ Physiol 278, H1916-H1923
   Abstract »    Full Text »    PDF »
Impaired Conduction of Vasodilation Along Arterioles in Connexin40-Deficient Mice.
C. de Wit, F. Roos, S.-S. Bolz, S. Kirchhoff, O. Kruger, K. Willecke, and U. Pohl (2000)
Circ. Res. 86, 649-655
   Abstract »    Full Text »    PDF »
Resolution of smooth muscle and endothelial pathways for conduction along hamster cheek pouch arterioles.
I. S. Bartlett and S. S. Segal (2000)
Am J Physiol Heart Circ Physiol 278, H604-H612
   Abstract »    Full Text »    PDF »
Endothelial Cell Pathway for Conduction of Hyperpolarization and Vasodilation Along Hamster Feed Artery.
G. G. Emerson and S. S. Segal (2000)
Circ. Res. 86, 94-100
   Abstract »    Full Text »    PDF »
Vasomotor control in arterioles of the mouse cremaster muscle.
J. E. HUNGERFORD, W. C. SESSA, and S. S. SEGAL (2000)
FASEB J 14, 197-207
   Abstract »    Full Text »
Angiotensin II modulates conducted vasoconstriction to norepinephrine and local electrical stimulation in rat mesenteric arterioles.
F. Gustafsson and N.-H. Holstein-Rathlou (1999)
Cardiovasc Res 44, 176-184
   Abstract »    Full Text »    PDF »
Aortic Connexin43 Is Decreased During Hypertension Induced by Inhibition of Nitric Oxide Synthase.
J.-A. Haefliger, P. Meda, A. Formenton, P. Wiesel, A. Zanchi, H. R. Brunner, P. Nicod, and D. Hayoz (1999)
Arterioscler Thromb Vasc Biol 19, 1615-1622
   Abstract »    Full Text »    PDF »
Spread of vasodilatation and vasoconstriction along feed arteries and arterioles of hamster skeletal muscle.
S. S Segal, D. G Welsh, and D. T Kurjiaka (1999)
J. Physiol. 516, 283-291
   Abstract »    Full Text »    PDF »
Cardiovascular physiology in the twentieth century: great strides and missed opportunities.
H. J. Granger (1998)
Am J Physiol Heart Circ Physiol 275, H1925-H1936
   Abstract »    Full Text »    PDF »
Connexin43 Is Highly Localized to Sites of Disturbed Flow in Rat Aortic Endothelium but Connexin37 and Connexin40 Are More Uniformly Distributed.
J. E. Gabriels and D. L. Paul (1998)
Circ. Res. 83, 636-643
   Abstract »    Full Text »    PDF »
Voltage-gated sodium channels in cardiac microvascular endothelial cells.
K. B. Walsh, M. B. Wolf, and J. Fan (1998)
Am J Physiol Heart Circ Physiol 274, H506-H512
   Abstract »    Full Text »    PDF »
Capillaries demonstrate changes in membrane potential in response to pharmacological stimuli.
E. D. McGahren, J. M. Beach, and B. R. Duling (1998)
Am J Physiol Heart Circ Physiol 274, H60-H65
   Abstract »    Full Text »    PDF »
Endothelial and smooth muscle cell conduction in arterioles controlling blood flow.
D. G. Welsh and S. S. Segal (1998)
Am J Physiol Heart Circ Physiol 274, H178-H186
   Abstract »    Full Text »    PDF »
Local and Propagated Vascular Responses Evoked by Focal Synaptic Activity in Cerebellar Cortex.
C. Iadecola, G. Yang, T. J. Ebner, and G. Chen (1997)
J Neurophysiol 78, 651-659
   Abstract »    Full Text »    PDF »
Hypertension Increases Connexin43 in a Tissue-Specific Manner.
J.-A. Haefliger, E. Castillo, G. Waeber, G. E. Bergonzelli, J.-F. Aubert, E. Sutter, P. Nicod, B. Waeber, and P. Meda (1997)
Circulation 95, 1007-1014
   Abstract »    Full Text »
Precapillary Servo Control of Blood Pressure and Postcapillary Adjustment of Flow to Tissue Metabolic Status: A New Paradigm for Local Perfusion Regulation.
K. Groebe (1996)
Circulation 94, 1876-1885
   Abstract »    Full Text »
Gap Junctions in Vascular Tissues: Evaluating the Role of Intercellular Communication in the Modulation of Vasomotor Tone.
G. J. Christ, D. C. Spray, M. El-Sabban, L. K. Moore, and P. R. Brink (1996)
Circ. Res. 79, 631-646
   Abstract »    Full Text »
Muscle Length Directs Sympathetic Nerve Activity and Vasomotor Tone in Resistance Vessels of Hamster Retractor.
D. G. Welsh and S. S. Segal (1996)
Circ. Res. 79, 551-559
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)