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Science 14 November 1986:
Vol. 234. no. 4778, pp. 866 - 868
DOI: 10.1126/science.3022377
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Articles

Science, Vol 234, Issue 4778, 866-868
Copyright © 1986 by American Association for the Advancement of Science

articles

Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse

O Heidmann, A Buonanno, B Geoffroy, B Robert, JL Guenet, JP Merlie, and JP Changeux

The chromosomal localization of the genes encoding the four subunits of muscle nicotinic receptor was determined by analyzing restriction fragment length polymorphisms between two mouse species Mus musculus domesticus (DBA/2) and Mus spretus (SPE). Analysis of the progeny of the interspecies mouse backcross (DBA/2 X SPE) X DBA/2 showed that the alpha-subunit gene cosegregates with the alpha-cardiac actin gene on chromosome 17, that the beta-subunit gene is located on chromosome 11, and that the gamma- and delta-subunit genes cosegregate and are located on chromosome 1.


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E. A. Ivakine, C. J. Fox, A. D. Paterson, S. M. Mortin-Toth, A. Canty, D. S. Walton, K. Aleksa, S. Ito, and J. S. Danska (2005)
J. Immunol. 174, 7129-7140
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Compartmentalization of Acetylcholine Receptor Gene Expression during Development of the Neuromuscular Junction.
J.P. Changeux, C. Babinet, J.L. Bessereau, A. Bessis, A. Cartaud, J. Cartaud, P. Daubas, A. Devillers-Thiery, A. Duclert, J.A. Hill, et al. (1990)
Cold Spring Harb Symp Quant Biol 55, 381-396
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