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Science 7 November 1986:
Vol. 234. no. 4777, pp. 740 - 743
DOI: 10.1126/science.2877492
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Articles
Science, Vol 234, Issue 4777, 740-743
Copyright © 1986 by American Association for the Advancement of Science
A pseudoautosomal gene in man
PJ Goodfellow,
SM Darling,
NS Thomas,
and
PN Goodfellow
The X/Y homologous gene MIC2 was shown to exchange between the sex chromosomes, thus demonstrating that it is a pseudoautosomal gene in man. MIC2 recombines with the sex-determining gene(s) TDF at a frequency of 2 to 3 percent. It is the most proximal pseudoautosomal locus thus far described and as such is an important marker for use in studies directed towards the isolation of TDF.
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