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Science 31 October 1986:
Vol. 234. no. 4776, pp. 596 - 601
DOI: 10.1126/science.2876520
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Articles

Science, Vol 234, Issue 4776, 596-601
Copyright © 1986 by American Association for the Advancement of Science

articles

Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders

SZ Salahuddin, DV Ablashi, PD Markham, SF Josephs, S Sturzenegger, M Kaplan, G Halligan, P Biberfeld, F Wong-Staal, B Kramarsky, and al. et

A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals: two HTLV-III seropositive patients from the United States (one with AIDS-related lymphoma and one with dermatopathic lymphadenopathy), three HTLV-III seronegative patients from the United States (one with angioimmunoblastic lymphadenopathy, one with cutaneous T-cell lymphoma, and one with immunoblastic lymphoma), and one HTLV-III seronegative patient with acute lymphocytic leukemia from Jamaica. All six isolates were closely related by antigenic analysis, and sera from all six virus-positive patients reacted immunologically with each virus isolate. In contrast, only four sera from 220 randomly selected healthy donors and none from 12 AIDS patients without associated lymphoma were seropositive. The virus selectively infected freshly isolated human B cells and converted them into large, refractile mono- or binucleated cells with nuclear and cytoplasmic inclusion bodies. HBLV is morphologically similar to viruses of the herpesvirus family but is readily distinguishable from the known human and nonhuman primate herpesviruses by host range, in vitro biological effects, and antigenic features.


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Extrahippocampal Involvement in Human Herpesvirus 6 Encephalitis Depicted at MR Imaging.
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Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum.
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Characterization of the Human Herpesvirus 6 U69 Gene Product and Identification of Its Nuclear Localization Signal.
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Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner.
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Human Herpesvirus 6A (HHV-6A) and HHV-6B Alter E2F1/Rb Pathways and E2F1 Localization and Cause Cell Cycle Arrest in Infected T Cells.
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J. Virol. 81, 13499-13508
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Identification of Human Herpesvirus 6 in a Patient With Severe Unilateral Panuveitis.
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Inhibition of Transcription of the Beta Interferon Gene by the Human Herpesvirus 6 Immediate-Early 1 Protein.
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J. Virol. 81, 5737-5748
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Human Herpesvirus 6 DNA Levels in Cerebrospinal Fluid Due to Primary Infection Differ from Those Due to Chromosomal Viral Integration and Have Implications for Diagnosis of Encephalitis.
K. N. Ward, H. N. Leong, A. D. Thiruchelvam, C. E. Atkinson, and D. A. Clark (2007)
J. Clin. Microbiol. 45, 1298-1304
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Human herpesvirus 6A accelerates AIDS progression in macaques.
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J. Virol. 81, 708-717
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Mollaret's Meningitis Due to Human Herpesvirus 6 in an Adolescent.
J. D. Capouya, D. M. Berman, and J. A. Dumois (2006)
Clinical Pediatrics 45, 861-863
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Functional Interaction between Human Herpesvirus 6 Immediate-Early 2 Protein and Ubiquitin-Conjugating Enzyme 9 in the Absence of Sumoylation..
A. Tomoiu, A. Gravel, R. M. Tanguay, and L. Flamand (2006)
J. Virol. 80, 10218-10228
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Human herpesvirus-6 dysregulates monocyte-mediated anticryptococcal defences.
C. Cermelli, V. Cenacchi, F. Beretti, F. Pezzini, D. D. Luca, and E. Blasi (2006)
J. Med. Microbiol. 55, 695-702
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Human herpesvirus 6 envelope cholesterol is required for virus entry.
H. Huang, Y. Li, T. Sadaoka, H. Tang, T. Yamamoto, K. Yamanishi, and Y. Mori (2006)
J. Gen. Virol. 87, 277-285
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Human Herpesvirus 6 Open Reading Frame U14 Protein and Cellular p53 Interact with Each Other and Are Contained in the Virion.
M. Takemoto, M. Koike, Y. Mori, S. Yonemoto, Y. Sasamoto, K. Kondo, Y. Uchiyama, and K. Yamanishi (2005)
J. Virol. 79, 13037-13046
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The Human Herpesvirus 6 G Protein-Coupled Receptor Homolog U51 Positively Regulates Virus Replication and Enhances Cell-Cell Fusion In Vitro.
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J. Virol. 79, 11914-11924
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A novel homologue of Human herpesvirus 6 in chimpanzees.
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Variant-Specific Tropism of Human Herpesvirus 6 in Human Astrocytes.
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J. Virol. 79, 9439-9448
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Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland.
K N Ward, N J Andrews, C M Verity, E Miller, and E M Ross (2005)
Arch. Dis. Child. 90, 619-623
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Viral Replication-Independent Blockade of Dendritic Cell Maturation and Interleukin-12 Production by Human Herpesvirus 6.
A. P. Smith, C. Paolucci, G. Di Lullo, S. E. Burastero, F. Santoro, and P. Lusso (2005)
J. Virol. 79, 2807-2813
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Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter.
M. L. Opsahl and P. G. E. Kennedy (2005)
Brain 128, 516-527
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Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy.
L. De Bolle, L. Naesens, and E. De Clercq (2005)
Clin. Microbiol. Rev. 18, 217-245
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Relapsing-Remitting Multiple Sclerosis and Human Herpesvirus 6 Active Infection.
R. Alvarez-Lafuente, V. De las Heras, M. Bartolome, J. J. Picazo, and R. Arroyo (2004)
Arch Neurol 61, 1523-1527
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Intracellular Processing of Human Herpesvirus 6 Glycoproteins Q1 and Q2 into Tetrameric Complexes Expressed on the Viral Envelope.
P. Akkapaiboon, Y. Mori, T. Sadaoka, S. Yonemoto, and K. Yamanishi (2004)
J. Virol. 78, 7969-7983
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Infection with an Endemic Human Herpesvirus Disrupts Critical Glial Precursor Cell Properties.
J. Dietrich, B. M. Blumberg, M. Roshal, J. V. Baker, S. D. Hurley, M. Mayer-Proschel, and D. J. Mock (2004)
J. Neurosci. 24, 4875-4883
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Discovery of a Second Form of Tripartite Complex Containing gH-gL of Human Herpesvirus 6 and Observations on CD46.
Y. Mori, P. Akkapaiboon, S. Yonemoto, M. Koike, M. Takemoto, T. Sadaoka, Y. Sasamoto, S. Konishi, Y. Uchiyama, and K. Yamanishi (2004)
J. Virol. 78, 4609-4616
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Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis.
M. Takemoto, Y. Mori, K. Ueda, K. Kondo, and K. Yamanishi (2004)
J. Gen. Virol. 85, 869-879
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Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.
D. Donati, N. Akhyani, A. Fogdell-Hahn, C. Cermelli, R. Cassiani-Ingoni, A. Vortmeyer, J. D. Heiss, P. Cogen, W. D. Gaillard, S. Sato, et al. (2003)
Neurology 61, 1405-1411
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Selective suppression of IL-12 production by human herpesvirus 6.
A. Smith, F. Santoro, G. Di Lullo, L. Dagna, A. Verani, and P. Lusso (2003)
Blood 102, 2877-2884
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Pathogenic Effects of Human Herpesvirus 6 in Human Lymphoid Tissue Ex Vivo.
J.-C. Grivel, F. Santoro, S. Chen, G. Faga, M. S. Malnati, Y. Ito, L. Margolis, and P. Lusso (2003)
J. Virol. 77, 8280-8289
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Variant A Glycoprotein H-Glycoprotein L-Glycoprotein Q Complex Associates with Human CD46.
Y. Mori, X. Yang, P. Akkapaiboon, T. Okuno, and K. Yamanishi (2003)
J. Virol. 77, 4992-4999
   Abstract »    Full Text »    PDF »
A Highly Selective CCR2 Chemokine Agonist Encoded by Human Herpesvirus 6.
H. R. Luttichau, I. Clark-Lewis, P. O. Jensen, C. Moser, J. Gerstoft, and T. W. Schwartz (2003)
J. Biol. Chem. 278, 10928-10933
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The Human Herpesvirus 6 U100 Gene Product Is the Third Component of the gH-gL Glycoprotein Complex on the Viral Envelope.
Y. Mori, P. Akkapaiboon, X. Yang, and K. Yamanishi (2003)
J. Virol. 77, 2452-2458
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Herpesvirus Infections in Organ Transplant Recipients.
F. J. Jenkins, D. T. Rowe, and C. R. Rinaldo Jr. (2003)
Clin. Vaccine Immunol. 10, 1-7
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Human herpesvirus 6: molecular biology and clinical features.
D.H. Dockrell (2003)
J. Med. Microbiol. 52, 5-18
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Phenotypic and Functional Alterations of Dendritic Cells Induced by Human Herpesvirus 6 Infection.
M. Kakimoto, A. Hasegawa, S. Fujita, and M. Yasukawa (2002)
J. Virol. 76, 10338-10345
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Human Herpesvirus 6 and Measles Virus Employ Distinct CD46 Domains for Receptor Function.
H. L. Greenstone, F. Santoro, P. Lusso, and E. A. Berger (2002)
J. Biol. Chem. 277, 39112-39118
   Abstract »    Full Text »    PDF »
Role of the Human Herpesvirus 6 U69-Encoded Kinase in the Phosphorylation of Ganciclovir.
L. De Bolle, D. Michel, T. Mertens, C. Manichanh, H. Agut, E. De Clercq, and L. Naesens (2002)
Mol. Pharmacol. 62, 714-721
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High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients.
J. Sashihara, K. Tanaka-Taya, S. Tanaka, K. Amo, H. Miyagawa, G. Hosoi, T. Taniguchi, T. Fukui, N. Kasuga, T. Aono, et al. (2002)
Blood 100, 2005-2011
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Activation of Monocyte Cyclooxygenase-2 Gene Expression by Human Herpesvirus 6. ROLE FOR CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN AND ACTIVATOR PROTEIN-1.
M.-E. Janelle, A. Gravel, J. Gosselin, M. J. Tremblay, and L. Flamand (2002)
J. Biol. Chem. 277, 30665-30674
   Abstract »    Full Text »    PDF »
Viral Gene Expression Patterns in Human Herpesvirus 6B-Infected T Cells.
B. Oster and P. Hollsberg (2002)
J. Virol. 76, 7578-7586
   Abstract »    Full Text »    PDF »
Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases.
D. V. Ablashi, L. G. Chatlynne, J. E. Whitman Jr., and E. Cesarman (2002)
Clin. Microbiol. Rev. 15, 439-464
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Real-Time PCR for Quantification of Human Herpesvirus 6 DNA from Lymph Nodes and Saliva.
S. Collot, B. Petit, D. Bordessoule, S. Alain, M. Touati, F. Denis, and S. Ranger-Rogez (2002)
J. Clin. Microbiol. 40, 2445-2451
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Variant A but Not Variant B Induces Fusion from Without in a Variety of Human Cells through a Human Herpesvirus 6 Entry Receptor, CD46.
Y. Mori, T. Seya, H. L. Huang, P. Akkapaiboon, P. Dhepakson, and K. Yamanishi (2002)
J. Virol. 76, 6750-6761
   Abstract »    Full Text »    PDF »
Detection of Viral DNA and Immune Responses to the Human Herpesvirus 6 101-Kilodalton Virion Protein in Patients with Multiple Sclerosis and in Controls.
M. V. Tejada-Simon, Y. C. Q. Zang, J. Hong, V. M. Rivera, J. M. Killian, and J. Z. Zhang (2002)
J. Virol. 76, 6147-6154
   Abstract »    Full Text »    PDF »
Characterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus).
H. B. Jenson, Y. Ench, Y. Zhang, S.-J. Gao, J. R. Arrand, and M. Mackett (2002)
J. Gen. Virol. 83, 1621-1633
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Immediate-Early 1 Protein Is a Sumoylated Nuclear Phosphoprotein Colocalizing with Promyelocytic Leukemia Protein-associated Nuclear Bodies.
A. Gravel, J. Gosselin, and L. Flamand (2002)
J. Biol. Chem. 277, 19679-19687
   Abstract »    Full Text »    PDF »
Human herpesvirus-6 rep/U94 gene product has single-stranded DNA-binding activity.
P. Dhepakson, Y. Mori, Y. B. Jiang, H. L. Huang, P. Akkapaiboon, T. Okuno, and K. Yamanishi (2002)
J. Gen. Virol. 83, 847-854
   Abstract »    Full Text »    PDF »
Neutralizing Antibody Responses to Human Herpesviruses 6 and 7 Do Not Cross-React with Each Other, and Maternal Neutralizing Antibodies Contribute to Sequential Infection with These Viruses in Childhood.
M. Yoshida, S. Torigoe, K. Ikeue, and M. Yamada (2002)
Clin. Vaccine Immunol. 9, 388-393
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Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies.
M. Yoshida, S. Torigoe, and M. Yamada (2002)
Clin. Vaccine Immunol. 9, 394-402
   Abstract »    Full Text »    PDF »
Gene Expression Profile of Herpesvirus-Infected T Cells Obtained Using Immunomicroarrays: Induction of Proinflammatory Mechanisms.
M. Mayne, C. Cheadle, S. S. Soldan, C. Cermelli, Y. Yamano, N. Akhyani, J. E. Nagel, D. D. Taub, K. G. Becker, and S. Jacobson (2001)
J. Virol. 75, 11641-11650
   Abstract »    Full Text »    PDF »
Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo.
C. Manichanh, C. Olivier-Aubron, J.-P. Lagarde, J.-T. Aubin, P. Bossi, A. Gautheret-Dejean, J.-M. Huraux, and H. Agut (2001)
J. Gen. Virol. 82, 2767-2776
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The R3 Region, One of Three Major Repetitive Regions of Human Herpesvirus 6, Is a Strong Enhancer of Immediate-Early Gene U95.
M. Takemoto, T. Shimamoto, Y. Isegawa, and K. Yamanishi (2001)
J. Virol. 75, 10149-10160
   Abstract »    Full Text »    PDF »
Frequent Detection of the Human Herpesvirus 6-Specific Genomes in the Livers of Children with Various Liver Diseases.
Y. Ozaki, H. Tajiri, K. Tanaka-Taya, S. Mushiake, A. Kimoto, K. Yamanishi, and S. Okada (2001)
J. Clin. Microbiol. 39, 2173-2177
   Abstract »    Full Text »    PDF »
Definition of a Divergent Epitope That Allows Differential Detection of Early Protein p41 from Human Herpesvirus 6 Variants A and B.
Y. Xu, A. Linde, H. Dahl, and G. Winberg (2001)
J. Clin. Microbiol. 39, 1449-1455
   Abstract »    Full Text »    PDF »
Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections.
K. N. Ward, D. J. Turner, X. C. Parada, and A. D. Thiruchelvam (2001)
J. Clin. Microbiol. 39, 959-963
   Abstract »    Full Text »    PDF »
Transcriptional Down-Regulation of CXC Chemokine Receptor 4 Induced by Impaired Association of Transcription Regulator YY1 with c-Myc in Human Herpesvirus 6-Infected Cells.
A. Hasegawa, M. Yasukawa, I. Sakai, and S. Fujita (2001)
J. Immunol. 166, 1125-1131
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Comparison of Specific Serological Assays for Diagnosing Human Herpesvirus 6 Infection after Liver Transplantation.
T. Yoshikawa, J. B. Black, M. Ihira, K. Suzuki, S. Suga, K. Iida, Y. Saito, K. Asonuma, K. Tanaka, and Y. Asano (2001)
Clin. Vaccine Immunol. 8, 170-173
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Characterization of Transcripts Expressed from Human Herpesvirus 6A Strain GS Immediate-Early Region B U16-U17 Open Reading Frames.
L. M. Flebbe-Rehwaldt, C. Wood, and B. Chandran (2000)
J. Virol. 74, 11040-11054
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Real-Time Quantitative PCR for Human Herpesvirus 6 DNA.
G. Locatelli, F. Santoro, F. Veglia, A. Gobbi, P. Lusso, and M. S. Malnati (2000)
J. Clin. Microbiol. 38, 4042-4048
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Coinfection of SCID-hu Thy/Liv Mice with Human Herpesvirus 6 and Human Immunodeficiency Virus Type 1.
A. Gobbi, C. A. Stoddart, G. Locatelli, F. Santoro, C. Bare, V. Linquist-Stepps, M. E. Moreno, N. W. Abbey, B. G. Herndier, M. S. Malnati, et al. (2000)
J. Virol. 74, 8726-8731
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Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7.
F M Mattes, J E McLaughlin, V C Emery, D A Clark, and P D Griffiths (2000)
J. Clin. Pathol. 53, 612-614
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Expression of Human Herpesvirus 6B rep within Infected Cells and Binding of Its Gene Product to the TATA-Binding Protein In Vitro and In Vivo.
Y. Mori, P. Dhepakson, T. Shimamoto, K. Ueda, Y. Gomi, H. Tani, Y. Matsuura, and K. Yamanishi (2000)
J. Virol. 74, 6096-6104
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Management of herpes virus infections following transplantation.
(2000)
J. Antimicrob. Chemother. 45, 729-748
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Identification and Analysis of a Novel Heparin-Binding Glycoprotein Encoded by Human Herpesvirus 7.
D. Skrincosky, P. Hocknell, L. Whetter, P. Secchiero, B. Chandran, and S. Dewhurst (2000)
J. Virol. 74, 4530-4540
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Multiple Antiviral Activities of Cyanovirin-N: Blocking of Human Immunodeficiency Virus Type 1 gp120 Interaction with CD4 and Coreceptor and Inhibition of Diverse Enveloped Viruses.
B. Dey, D. L. Lerner, P. Lusso, M. R. Boyd, J. H. Elder, and E. A. Berger (2000)
J. Virol. 74, 4562-4569
   Abstract »    Full Text »    PDF »
Suppressive effects of human herpesvirus-6 on thrombopoietin-inducible megakaryocytic colony formation in vitro.
H. Isomura, M. Yoshida, H. Namba, N. Fujiwara, R. Ohuchi, F. Uno, M. Oda, Y. Seino, and M. Yamada (2000)
J. Gen. Virol. 81, 663-673
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Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A.
G. Dominguez, T. R. Dambaugh, F. R. Stamey, S. Dewhurst, N. Inoue, and P. E. Pellett (1999)
J. Virol. 73, 8040-8052
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Comparison of the Complete DNA Sequences of Human Herpesvirus 6 Variants A and B.
Y. Isegawa, T. Mukai, K. Nakano, M. Kagawa, J. Chen, Y. Mori, T. Sunagawa, K. Kawanishi, J. Sashihara, A. Hata, et al. (1999)
J. Virol. 73, 8053-8063
   Abstract »    Full Text »    PDF »
Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA.
M. Daibata, T. Taguchi, Y. Nemoto, H. Taguchi, and I. Miyoshi (1999)
Blood 94, 1545-1549
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Human Cytomegalovirus and Human Herpesvirus 6 Genes That Transform and Transactivate.
J. Doniger, S. Muralidhar, and L. J. Rosenthal (1999)
Clin. Microbiol. Rev. 12, 367-382
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine.
P. Zou, Y. Isegawa, K. Nakano, M. Haque, Y. Horiguchi, and K. Yamanishi (1999)
J. Virol. 73, 5926-5933
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 (HHV-6) Causes Severe Thymocyte Depletion in SCID-hu Thy/Liv Mice.
A. Gobbi, C. A. Stoddart, M. S. Malnati, G. Locatelli, F. Santoro, N. W. Abbey, C. Bare, V. Linquist-Stepps, M. B. Moreno, B. G. Herndier, et al. (1999)
J. Exp. Med. 189, 1953-1960
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Human Herpesvirus 6 Infects Dendritic Cells and Suppresses Human Immunodeficiency Virus Type 1 Replication in Coinfected Cultures.
H. Asada, V. Klaus-Kovtun, H. Golding, S. I. Katz, and A. Blauvelt (1999)
J. Virol. 73, 4019-4028
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Down-Regulation of CXCR4 by Human Herpesvirus 6 (HHV-6) and HHV-7.
M. Yasukawa, A. Hasegawa, I. Sakai, H. Ohminami, J. Arai, S. Kaneko, Y. Yakushijin, K. Maeyama, H. Nakashima, R. Arakaki, et al. (1999)
J. Immunol. 162, 5417-5422
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The U69 Gene of Human Herpesvirus 6 Encodes a Protein Kinase Which Can Confer Ganciclovir Sensitivity to Baculoviruses.
A. Ansari and V. C. Emery (1999)
J. Virol. 73, 3284-3291
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Latent Infection and Reactivation of Human Herpesvirus 6 in Two Novel Myeloid Cell Lines.
M. Yasukawa, H. Ohminami, E. Sada, Y. Yakushijin, M. Kaneko, K. Yanagisawa, H. Kohno, S. Bando, and S. Fujita (1999)
Blood 93, 991-999
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The New Herpesviruses: Emerging Pathogens of Dermatological Interest.
F. Drago and A. Rebora (1999)
Arch Dermatol 135, 71-75
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Human Herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report.
D V Ablashi, W Lapps, M Kaplan, J E Whitman, J R Richert, and G R Pearson (1998)
Multiple Sclerosis 4, 490-496
   Abstract »    PDF »
Viral Glycoproteins Accumulate in Newly Formed Annulate Lamellae following Infection of Lymphoid Cells by Human Herpesvirus 6.
G. Cardinali, M. Gentile, M. Cirone, C. Zompetta, L. Frati, A. Faggioni, and M. R. Torrisi (1998)
J. Virol. 72, 9738-9746
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Prospective Study of Persistence and Excretion of Human Herpesvirus-6 in Patients With Exanthem Subitum and Their Parents.
S. Suga, T. Yoshikawa, Y. Kajita, T. Ozaki, and Y. Asano (1998)
Pediatrics 102, 900-904
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Prediction of Human Herpesvirus 6 Infection After Allogeneic Bone Marrow Transplantation.
T. Yoshikawa, K. Suzuki, M. Ihira, H. Furukawa, S. Suga, Y. Asano, S. Kojima, K. Kato, and T. Matsuyama (1998)
Blood 92, 2597-2599
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Expression of Human Herpesvirus-6 Antigens in Benign and Malignant Lymphoproliferative Diseases.
M. Luppi, P. Barozzi, R. Garber, A. Maiorana, G. Bonacorsi, T. Artusi, R. Trovato, R. Marasca, and G. Torelli (1998)
Am. J. Pathol. 153, 815-823
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Infection as a Risk Factor for the Development of Severe Drug-Induced Hypersensitivity Syndrome.
Y. Suzuki, R. Inagi, T. Aono, K. Yamanishi, and T. Shiohara (1998)
Arch Dermatol 134, 1108-1112
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Severe Hypersensitivity Syndrome Due to Sulfasalazine Associated With Reactivation of Human Herpesvirus 6.
M. Tohyama, Y. Yahata, M. Yasukawa, R. Inagi, Y. Urano, K. Yamanishi, and K. Hashimoto (1998)
Arch Dermatol 134, 1113-1117
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Human Herpesviruses 6 and 7: New Roles Yet to Be Discovered?.
L. Le Cleach, A. M. Fillet, H. Agut, and O. Chosidow (1998)
Arch Dermatol 134, 1155-1157
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Human Herpesvirus 6 Open Reading Frame U12 Encodes a Functional beta -Chemokine Receptor.
Y. Isegawa, Z. Ping, K. Nakano, N. Sugimoto, and K. Yamanishi (1998)
J. Virol. 72, 6104-6112
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Temporal Mapping of Transcripts in Herpesvirus 6 Variants.
P. Mirandola, P. Menegazzi, S. Merighi, T. Ravaioli, E. Cassai, and D. Di Luca (1998)
J. Virol. 72, 3837-3844
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Mononucleosis syndrome and coincidental human herpesvirus-7 and Epstein-Barr virus infection.
H-H Chiu, C-Y Lee, P-I Lee, K-H Lin, and L-M Huang (1998)
Arch. Dis. Child. 78, 479-480
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Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures.
J. Hukin, K. Farrell, L. M MacWilliam, M. Colbourne, E. Waida, R. Tan, L. Mroz, and E. Thomas (1998)
Pediatrics 101 , e3
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 (HHV-6)-Positive Burkitt's Lymphoma: Establishment of a Novel Cell Line Infected With HHV-6.
K. Bandobashi, M. Daibata, M. Kamioka, Y. Tanaka, I. Kubonishi, H. Taguchi, Y. Ohtsuki, and I. Miyoshi (1997)
Blood 90, 1200-1207
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CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B.
W. Kempf, V. Adams, N. Wey, R. Moos, M. Schmid, E. Avitabile, and G. Campadelli-Fiume (1997)
PNAS 94, 7600-7605
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Identification of RANTES, MIP-1alpha, and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells.
F. Cocchi, A. L. DeVico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso (1995)
Science 270, 1811-1815
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Human Herpesvirus-6 Infection in Children -- A Prospective Study of Complications and Reactivation.
C. B. Hall, C. E. Long, K. C. Schnabel, M. T. Caserta, K. M. McIntyre, M. A. Costanzo, A. Knott, S. Dewhurst, R. A. Insel, and L. G. Epstein (1994)
N. Engl. J. Med. 331, 432-438
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Severe Infectious Mononucleosis-like Syndrome and Primary Human Herpesvirus 6 Infection in an Adult.
K. Akashi, Y. Eizuru, Y. Sumiyoshi, T. Minematsu, S. Hara, M. Harada, M. Kikuchi, Y. Niho, and Y. Minamishima (1993)
N. Engl. J. Med. 329, 168-171
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Puzzles Concerning the Pathogenicity of Human Herpesvirus 6.
H. Agut (1993)
N. Engl. J. Med. 329, 203-204
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