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Science 17 October 1986:
Vol. 234. no. 4774, pp. 355 - 358
DOI: 10.1126/science.2429366
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Articles

Science, Vol 234, Issue 4774, 355-358
Copyright © 1986 by American Association for the Advancement of Science

articles

An early event in the interferon-induced transmembrane signaling process

WH Yap, TS Teo, and YH Tan

Human interferon stimulates a transient two- to threefold increase in the concentration of diacylglycerol and inositol tris-phosphate within 15 to 30 seconds of cell exposure to interferon. Antibodies to interferon inhibit this effect. The stimulation was measurable in isolated cell membranes exposed to interferon. Human alpha and beta, but not gamma, interferon stimulate this increase in cells containing the appropriate interferon receptor. The effect was proportional to the number of interferon receptors. Both the diacylglycerol increase and antiviral effects induced by interferon could be correlated in terms of dose dependence. Thus, a transient diacylglycerol increase is an early event in the interferon-induced transmembrane signaling process.


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