Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 October 1986:
Vol. 234. no. 4772, pp. 71 - 73
DOI: 10.1126/science.3749893
Prev | Table of Contents | Next

Articles

Science, Vol 234, Issue 4772, 71-73
Copyright © 1986 by American Association for the Advancement of Science

articles

Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin and cholecystokinin

RJ Nachman, GM Holman, WF Haddon, and N Ling

A sulfated, myotropic neuropeptide termed leucosulfakinin (Glu-Gln-Phe-Glu-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2) was isolated from head extracts of the cockroach Leucophaea maderae. The peptide exhibits sequence homology with the hormonally active portion of the vertebrate hormones human gastrin II and cholecystokinin, suggesting that these peptides are evolutionarily related. Six of the 11 amino acid residues (55 percent) are identical to those in gastrin II. In addition, the intestinal myotropic action of leucosulfakinin is analogous to that of gastrin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Discovery of a Cholecystokinin-Gastrin-Like Signaling System in Nematodes.
T. Janssen, E. Meelkop, M. Lindemans, K. Verstraelen, S. J. Husson, L. Temmerman, R. J. Nachman, and L. Schoofs (2008)
Endocrinology 149, 2826-2839
   Abstract »    Full Text »    PDF »
Identification and cardiotropic actions of sulfakinin peptides in the American lobster Homarus americanus.
P. S. Dickinson, J. S. Stevens, S. Rus, H. R. Brennan, C. C. Goiney, C. M. Smith, L. Li, D. W. Towle, and A. E. Christie (2007)
J. Exp. Biol. 210, 2278-2289
   Abstract »    Full Text »    PDF »
Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila.
G. Marques, T. E. Haerry, M. L. Crotty, M. Xue, B. Zhang, and M. B. O'Connor (2003)
Development 130, 5457-5470
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)