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Science 26 September 1986:
Vol. 233. no. 4771, pp. 1425 - 1427
DOI: 10.1126/science.3018925
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Articles

Science, Vol 233, Issue 4771, 1425-1427
Copyright © 1986 by American Association for the Advancement of Science

articles

Tandem duplication of D-loop and ribosomal RNA sequences in lizard mitochondrial DNA

C Moritz and WM Brown

Some Cnemidophorus exsanguis have mitochondrial DNA's (mtDNA's) that are 22.2 kilobases (kb) in size, whereas most have mtDNA's of 17.4 kb. Restriction site mapping, DNA transfer hybridization experiments, and electron microscopy show that the size increment stems from the tandem duplication of a 4.8-kb region that includes regulatory sequences and transfer and ribosomal RNA genes. This observation is notable in that sequences outside of the control region are involved in major length variation. Besides revealing a novel form of mtDNA evolution in animals, these duplications provide a useful system for investigating the molecular and evolutionary biology of animal mtDNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Hotspot of Gene Order Rearrangement by Tandem Duplication and Random Loss in the Vertebrate Mitochondrial Genome.
D. San Mauro, D. J. Gower, R. Zardoya, and M. Wilkinson (2006)
Mol. Biol. Evol. 23, 227-234
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Molecular Mechanisms of Extensive Mitochondrial Gene Rearrangement in Plethodontid Salamanders.
R. L. Mueller and J. L. Boore (2005)
Mol. Biol. Evol. 22, 2104-2112
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Evolution of the Deep-Sea Gulper Eel Mitochondrial Genomes: Large-Scale Gene Rearrangements Originated Within the Eels.
J. G. Inoue, M. Miya, K. Tsukamoto, and M. Nishida (2003)
Mol. Biol. Evol. 20, 1917-1924
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Complete mtDNA Sequences of Two Millipedes Suggest a New Model for Mitochondrial Gene Rearrangements: Duplication and Nonrandom Loss.
D. V. Lavrov, J. L. Boore, and W. M. Brown (2002)
Mol. Biol. Evol. 19, 163-169
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Duplication and Concerted Evolution of the Mitochondrial Control Region in the Parrot Genus Amazona.
J. R. Eberhard, T. F. Wright, and E. Bermingham (2001)
Mol. Biol. Evol. 18, 1330-1342
   Abstract »    Full Text »    PDF »
Mytilus Mitochondrial DNA Contains a Functional Gene for a tRNASer(UCN) With a Dihydrouridine Arm-Replacement Loop and a pseudo-tRNASer(UCN) Gene.
C. T. Beagley, R. Okimoto, and D. R. Wolstenholme (1999)
Genetics 152, 641-652
   Abstract »    Full Text »
Multiple independent origins of mitochondrial gene order in birds.
D. P. Mindell, M. D. Sorenson, and D. E. Dimcheff (1998)
PNAS 95, 10693-10697
   Abstract »    Full Text »    PDF »
The Complete Nucleotide Sequence of a Snake (Dinodon semicarinatus) Mitochondrial Genome With Two Identical Control Regions.
Y. Kumazawa, H. Ota, M. Nishida, and T. Ozawa (1998)
Genetics 150, 313-329
   Abstract »    Full Text »
Heteroplasmy suggests limited biparental inheritance of Mytilus mitochondrial DNA.
W. Hoeh, K. Blakley, and W. Brown (1991)
Science 251, 1488-1490
   Abstract »    PDF »


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