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Science 26 September 1986:
Vol. 233. no. 4771, pp. 1420 - 1422
DOI: 10.1126/science.3749886
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Articles

Science, Vol 233, Issue 4771, 1420-1422
Copyright © 1986 by American Association for the Advancement of Science

articles

Amitotic neuroblastoma cells used for neural implants in monkeys

DM Gash, MF Notter, SH Okawara, AL Kraus, and RJ Joynt

The potential utility of cultured neuroblastoma cells as donor tissue for neutral implants into the mammalian brain has been examined. Cells from a human neuroblastoma cell line, IMR-32, were labeled with [3H]thymidine and chemically rendered amitotic. These differentiated IMR-32 cells were grafted into the hippocampi of five adult African Green monkeys, and graft survival was evaluated for up to 270 days after transplantation. Autoradiographically labeled grafted cells were identified in four animals. Processes from grafted cells could be followed for distances of up to 150 micrometers into the host brain. No evidence for neoplastic growth of the transplant was found. Thus, grafted neuroblastoma cells can survive for prolonged periods in the primate brain and may serve as a practical source of donor tissue for neural implants.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neural transplantation: a call for patience rather than patients.
J. Sladek Jr and I Shoulson (1988)
Science 240, 1386-1388
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