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Science 12 September 1986:
Vol. 233. no. 4769, pp. 1197 - 1200
DOI: 10.1126/science.2426784
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Articles

Science, Vol 233, Issue 4769, 1197-1200
Copyright © 1986 by American Association for the Advancement of Science

articles

Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation

KG Chandy, TE DeCoursey, M Fischbach, N Talal, MD Cahalan, and S Gupta

The observation that voltage-dependent K+ channels are required for activation of human T lymphocytes suggests that pathological conditions involving abnormal mitogen responses might be reflected in ion channel abnormalities. Gigaohm seal techniques were used to study T cells from MRL/MpJ-lpr/lpr mice; these mice develop generalized lymphoproliferation of functionally and phenotypically abnormal T cells and a disease resembling human systemic lupus erythematosus. The number and predominant type of K+ channels in T cells from these mice differ dramatically from those in T cells from control strains and a congenic strain lacking the lpr gene locus. Thus an abnormal pattern of ion channel expression has now been associated with a genetic defect in cells of the immune system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Subset-specific expression of potassium channels in developing murine T lymphocytes.
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