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Science 12 September 1986:
Vol. 233. no. 4769, pp. 1192 - 1194
DOI: 10.1126/science.3461564
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Articles

Science, Vol 233, Issue 4769, 1192-1194
Copyright © 1986 by American Association for the Advancement of Science

articles

Correction of murine beta-thalassemia by gene transfer into the germ line

F Costantini, K Chada, and J Magram

A murine beta-thalassemia was corrected by the transfer of cloned beta-globin genes into the mouse germ line. The cloned mouse beta maj-globin gene or the cloned human beta-globin gene was introduced into mice deficient in beta-globin synthesis because of a deletion of the beta maj-globin gene. Both introduced genes produced functional beta-globin chains, leading to a reduction in one case, and elimination in another case, of the anemia and associated abnormalities of the red blood cells.


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The Molecular Genetic Revolution: Its Impact on Clinical Neurology.
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Transgenic animals.
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