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Science 5 September 1986:
Vol. 233. no. 4768, pp. 1078 - 1080
DOI: 10.1126/science.3461562
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Articles

Science, Vol 233, Issue 4768, 1078-1080
Copyright © 1986 by American Association for the Advancement of Science

articles

Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets

RL Heimark, DR Twardzik, and SM Schwartz

Damage to the vessel wall is a signal for endothelial migration and replication and for platelet release at the site of injury. Addition of transforming growth factor-beta (TGF-beta) purified from platelets to growing aortic endothelial cells inhibited [3H]thymidine incorporation in a concentration-dependent manner. A transient inhibition of DNA synthesis was also observed in response to wounding; cell migration and replication are inhibited during the first 24 hours after wounding. By 48 hours after wounding both TGF-beta-treated and -untreated cultures showed similar responses. Flow microfluorimetric analysis of cell cycle distribution indicated that after 24 hours of exposure to TGF-beta the cells were blocked from entering S phase, and the fraction of cells in G1 was increased. The inhibition of the initiation of regeneration by TGF-beta could allow time for recruitment of smooth muscle cells into the site of injury by other platelet components.


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