Science 22 August 1986: Vol. 233. no. 4766, pp. 859 - 866 DOI: 10.1126/science.3755548

Prev | Table of Contents | Next

Articles

The Ca2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate.

A. Radhakrishnan, A. Stein, R. Jahn, and D. Fasshauer (2009)
J. Biol. Chem. 284, 25749-25760
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of protein kinase C in diabetic nephropathy--where do we stand?.

J. Menne, M. Meier, J.-K. Park, and H. Haller (2009)
Nephrol. Dial. Transplant. 24, 2021-2023
 |  Full Text »  |  PDF »

A Pollen Protein, NaPCCP, That Binds Pistil Arabinogalactan Proteins Also Binds Phosphatidylinositol 3-Phosphate and Associates with the Pollen Tube Endomembrane System.

C. B. Lee, S. Kim, and B. McClure (2009)
Plant Physiology 149, 791-802
 |  Abstract »  |  Full Text »  |  PDF »

Arabidopsis Synaptotagmin 1 Is Required for the Maintenance of Plasma Membrane Integrity and Cell Viability.

A. L. Schapire, B. Voigt, J. Jasik, A. Rosado, R. Lopez-Cobollo, D. Menzel, J. Salinas, S. Mancuso, V. Valpuesta, F. Baluska, et al. (2008)
PLANT CELL 20, 3374-3388
 |  Abstract »  |  Full Text »  |  PDF »

Pollen Proteins Bind to the C-terminal Domain of Nicotiana alata Pistil Arabinogalactan Proteins.

C. B. Lee, K. N. Swatek, and B. McClure (2008)
J. Biol. Chem. 283, 26965-26973
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of PED/PEA-15 Molecular Interaction with Phospholipase D1 Enhances Insulin Sensitivity in Skeletal Muscle Cells.

F. Viparelli, A. Cassese, N. Doti, F. Paturzo, D. Marasco, N. A. Dathan, S. M. Monti, G. Basile, P. Ungaro, M. Sabatella, et al. (2008)
J. Biol. Chem. 283, 21769-21778
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta} mediates PTEN suppression and cell motility through calcium-dependent PKC-{alpha} activation in pancreatic cancer cells.

J. Y. C. Chow, H. Dong, K. T. Quach, P. N. Van Nguyen, K. Chen, and J. M. Carethers (2008)
Am J Physiol Gastrointest Liver Physiol 294, G899-G905
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin VII splice variants {alpha}, , and {delta} are expressed in pancreatic -cells and regulate insulin exocytosis.

B. R. Gauthier, D. L. Duhamel, M. Iezzi, S. Theander, F. Saltel, M. Fukuda, B. Wehrle-Haller, and C. B. Wollheim (2008)
FASEB J 22, 194-206
 |  Abstract »  |  Full Text »  |  PDF »

E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.

S.-W. Min, W.-P. Chang, and T. C. Sudhof (2007)
PNAS 104, 3823-3828
 |  Abstract »  |  Full Text »  |  PDF »

Specific Translocation of Protein Kinase C{alpha} to the Plasma Membrane Requires Both Ca2+ and PIP2 Recognition by Its C2 Domain.

J. H. Evans, D. Murray, C. C. Leslie, and J. J. Falke (2006)
Mol. Biol. Cell 17, 56-66
 |  Abstract »  |  Full Text »  |  PDF »

PKC-{delta} sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.

S. G. Brown, A. Thomas, L. V. Dekker, A. Tinker, and J. L. Leaney (2005)
Am J Physiol Cell Physiol 289, C543-C556
 |  Abstract »  |  Full Text »  |  PDF »

Relaxin Stimulates Protein Kinase C {zeta} Translocation: Requirement for Cyclic Adenosine 3',5'-Monophosphate Production.

B. T. Nguyen and C. W. Dessauer (2005)
Mol. Endocrinol. 19, 1012-1023
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties.

O.-H. Shin, W. Han, Y. Wang, and T. C. Sudhof (2005)
J. Biol. Chem. 280, 1641-1651
 |  Abstract »  |  Full Text »  |  PDF »

The Cytosolic Phospholipase A2 Catalytic Domain Modulates Association and Residence Time at Golgi Membranes.

J. H. Evans and C. C. Leslie (2004)
J. Biol. Chem. 279, 6005-6016
 |  Abstract »  |  Full Text »  |  PDF »

Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.

A. Siflinger-Birnboim and A. Johnson (2003)
Am J Physiol Lung Cell Mol Physiol 284, L435-L451
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and Prospect of Protein Kinase C Research: Epilogue.

Y. Nishizuka (2003)
J. Biochem. 133, 155-158
 |  Full Text »  |  PDF »

Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.

K. R. Birikh, E. H. Sklan, S. Shoham, and H. Soreq (2003)
PNAS 100, 283-288
 |  Abstract »  |  Full Text »  |  PDF »

The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore.

C. S. Stevenson, E. A. Capper, A. K. Roshak, B. Marquez, C. Eichman, J. R. Jackson, M. Mattern, W. H. Gerwick, R. S. Jacobs, and L. A. Marshall (2002)
J. Pharmacol. Exp. Ther. 303, 858-866
 |  Abstract »  |  Full Text »  |  PDF »

Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses.

M. Slevin, S. Kumar, and J. Gaffney (2002)
J. Biol. Chem. 277, 41046-41059
 |  Abstract »  |  Full Text »  |  PDF »

Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane.

C. Suzuki, G. Murakami, M. Fukuchi, T. Shimanuki, Y. Shikauchi, T. Imamura, and K. Miyazono (2002)
J. Biol. Chem. 277, 39919-39925
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Dynamics Characterization of the C2 Domain of Protein Kinase Cbeta.

L. Banci, G. Cavallaro, V. Kheifets, and D. Mochly-Rosen (2002)
J. Biol. Chem. 277, 12988-12997
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmins: Why So Many?.

T. C. Sudhof (2002)
J. Biol. Chem. 277, 7629-7632
 |  Full Text »  |  PDF »

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na+ channel regulation.

E. Kamynina, C. Tauxe, and O. Staub (2001)
Am J Physiol Renal Physiol 281, F469-F477
 |  Abstract »  |  Full Text »  |  PDF »

Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer.

J. A. Magee, T. Araki, S. Patil, T. Ehrig, L. True, P. A. Humphrey, W. J. Catalona, M. A. Watson, and J. Milbrandt (2001)
Cancer Res. 61, 5692-5696
 |  Abstract »  |  Full Text »  |  PDF »

Antigonadotropic Action of Adenosine Triphosphate in Human Granulosa-Luteal Cells: Involvement of Protein Kinase C{{alpha}}.

C.-J. Tai, S. K. Kang, K.-C. Choi, C.-R. Tzeng, and P. C. K. Leung (2001)
J. Clin. Endocrinol. Metab. 86, 3237-3242
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Multiple UNC-13 Proteins in the Caenorhabditis elegans Nervous System.

R. E. Kohn, J. S. Duerr, J. R. McManus, A. Duke, T. L. Rakow, H. Maruyama, G. Moulder, I. N. Maruyama, R. J. Barstead, and J. B. Rand (2000)
Mol. Biol. Cell 11, 3441-3452
 |  Abstract »  |  Full Text »

A Role for the beta Isoform of Protein Kinase C in Fear Conditioning.

E. J. Weeber, C. M. Atkins, J. C. Selcher, A. W. Varga, B. Mirnikjoo, R. Paylor, M. Leitges, and J. D. Sweatt (2000)
J. Neurosci. 20, 5906-5914
 |  Abstract »  |  Full Text »  |  PDF »

Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib.

P. J. Plant, F. Lafont, S. Lecat, P. Verkade, K. Simons, and D. Rotin (2000)
J. Cell Biol. 149, 1473-1484
 |  Abstract »  |  Full Text »  |  PDF »

Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha.

T. Ferro, P. Neumann, N. Gertzberg, R. Clements, and A. Johnson (2000)
Am J Physiol Lung Cell Mol Physiol 278, L1107-L1117
 |  Abstract »  |  Full Text »  |  PDF »

Myoferlin, a candidate gene and potential modifier of muscular dystrophy.

D. B. Davis, A. J. Delmonte, C. T. Ly, and E. M. McNally (2000)
Hum. Mol. Genet. 9, 217-226
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-Specific Protein Kinase C Isoform Expression in Rat Uterine Tissue.

T. T. Kim, T. Saunders, E. Bieber, and M. Phillippe (1999)
Reproductive Sciences 6, 293-300
 |  Abstract »  |  PDF »

Protein Kinase C and Calcineurin Synergize to Activate Ikappa B Kinase and NF-kappa B in T Lymphocytes.

S. A. Trushin, K. N. Pennington, A. Algeciras-Schimnich, and C. V. Paya (1999)
J. Biol. Chem. 274, 22923-22931
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm.

A. Zuniga, J. Torres, J. Ubeda, and R. Pulido (1999)
J. Biol. Chem. 274, 21900-21907
 |  Abstract »  |  Full Text »  |  PDF »

Calcium/Phospholipid-Dependent Protein Kinases in Rat Sertoli Cells: Regulation of Androgen Receptor Messenger Ribonucleic Acid.

A. Hansen Ree, V. Hansson, S. I. Walaas, W. Eskild, and K. Austlid Taskén (1999)
Biol Reprod 60, 1257-1262
 |  Abstract »  |  Full Text »

Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCßII mRNA in vascular smooth muscle cells.

N. A. Patel, C. E. Chalfant, M. Yamamoto, J. E. Watson, D. C. Eichler, and D. R. Cooper (1999)
FASEB J 13, 103-113
 |  Abstract »  |  Full Text »

Selective Role for beta -Protein Kinase C in Signaling for Obardot 2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells.

H. M. Korchak, M. W. Rossi, and L. E. Kilpatrick (1998)
J. Biol. Chem. 273, 27292-27299
 |  Abstract »  |  Full Text »  |  PDF »

Mapping of a Molecular Determinant for Protein Kinase C beta II Isozyme Function.

Y. Gokmen-Polar and A. P. Fields (1998)
J. Biol. Chem. 273, 20261-20266
 |  Abstract »  |  Full Text »  |  PDF »

ZmcPKC70, a Protein Kinase C-type Enzyme from Maize. BIOCHEMICAL CHARACTERIZATION, REGULATION BY PHORBOL 12-MYRISTATE 13-ACETATE AND ITS POSSIBLE INVOLVEMENT IN NITRATE REDUCTASE GENE EXPRESSION.

M. R. Chandok and S. K. Sopory (1998)
J. Biol. Chem. 273, 19235-19242
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenesis of the C2 Domain of Protein Kinase C-alpha . DIFFERENTIAL ROLES OF Ca2+ LIGANDS AND MEMBRANE BINDING RESIDUES.

M. Medkova and W. Cho (1998)
J. Biol. Chem. 273, 17544-17552
 |  Abstract »  |  Full Text »  |  PDF »

C2-domains, Structure and Function of a Universal Ca2+-binding Domain.

J. Rizo and T. C. Sudhof (1998)
J. Biol. Chem. 273, 15879-15882
 |  Full Text »  |  PDF »

Increased Protein Kinase C Activity in Myotrophin-Induced Myocyte Growth.

P. Sil, V. Kandaswamy, and S. Sen (1998)
Circ. Res. 82, 1173-1188
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of the C2A Domain of Synaptotagmin 1: Implications for Calcium-Regulated Secretion.

D. M. Thomas and L. A. Elferink (1998)
J. Neurosci. 18, 3511-3520
 |  Abstract »  |  Full Text »  |  PDF »

A Conserved Negative Regulatory Region in alpha PAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1.

Z.-S. Zhao, E. Manser, X.-Q. Chen, C. Chong, T. Leung, and L. Lim (1998)
Mol. Cell. Biol. 18, 2153-2163
 |  Abstract »  |  Full Text »  |  PDF »

Independent Folding and Ligand Specificity of the C2 Calciumdependent Lipid Binding Domain of Cytosolic Phospholipase A2.

E. A. Nalefski, T. McDonagh, W. Somers, J. Seehra, J. J. Falke, and J. D. Clark (1998)
J. Biol. Chem. 273, 1365-1372
 |  Abstract »  |  Full Text »  |  PDF »

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization.

P. J. Plant, H. Yeger, O. Staub, P. Howard, and D. Rotin (1997)
J. Biol. Chem. 272, 32329-32336
 |  Abstract »  |  Full Text »  |  PDF »

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cdelta.

P. Saharinen, N. Ekman, K. Sarvas, P. Parker, K. Alitalo, and O. Silvennoinen (1997)
Blood 90, 4341-4353
 |  Abstract »  |  Full Text »  |  PDF »

Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.

L. Luo, T. Lee, L. Tsai, G. Tang, L. Y. Jan, and Y. N. Jan (1997)
PNAS 94, 12963-12968
 |  Abstract »  |  Full Text »  |  PDF »

Amplification of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase Associated with Resistance to Alkylating Drugs in a Mammalian Cell Line.

K. Tano, W. C. Dunn, F. Darroudi, S. Shiota, R. J. Preston, A. T. Natarajan, and S. Mitra (1997)
J. Biol. Chem. 272, 13250-13254
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C Deficiency Blocks Recovery from Agonist-induced Desensitization.

M. Shih and C. C. Malbon (1996)
J. Biol. Chem. 271, 21478-21483
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of the Di-leucine-based Internalization Motif of the T Cell Receptor.

J. Dietrich, X. Hou, A.-M. K. Wegener, L.Øs. Pedersen, N. Odum, and C. Geisler (1996)
J. Biol. Chem. 271, 11441-11448
 |  Abstract »  |  Full Text »  |  PDF »

Endothelial Cell Tyrosine Kinase Receptor and G Protein–Coupled Receptor Activation Involves Distinct Protein Kinase C Isoforms.

H. Haller, W. Ziegler, C. Lindschau, and F. C. Luft (1996)
Arterioscler Thromb Vasc Biol 16, 678-686
 |  Abstract »  |  Full Text »

Phorbol Ester Regulation of Opioid Peptide Gene Expression in Myocardial Cells.

C. Ventura, G. Pintus, I. Vaona, F. Bennardini, G. Pinna, and B. Tadolini (1995)
J. Biol. Chem. 270, 30115-30120
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C: Structure, Function, and Regulation.

A. C. Newton and A. C. Newton (1995)
J. Biol. Chem. 270, 28495-28498
 |  Full Text »  |  PDF »

Determination of in Vivo Phosphorylation Sites in Protein Kinase C.

S. E. Tsutakawa, K. F. Medzihradszky, A. J. Flint, A. L. Burlingame, and D. E. Koshland , Jr. (1995)
J. Biol. Chem. 270, 26807-26812
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Interaction of Protein Kinase C with Phorbol Esters.

M. Mosior and A. C. Newton (1995)
J. Biol. Chem. 270, 25526-25533
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Phosphatidylserine-binding Region of Rat MARCKS (Myristoylated, Alanine-rich Protein Kinase C Substrate).

T. Nakaoka, N. Kojima, T. Ogita, and S. Tsuji (1995)
J. Biol. Chem. 270, 12147-12151
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylserine Decarboxylase 2 of Saccharomyces cerevisiáe.

P. J. Trotter, J. Pedretti, R. Yates, and D. R. Voelker (1995)
J. Biol. Chem. 270, 6071-6080
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C[IMAGE]-specific Phosphorylation of the Elongation Factor eEF-1alpha and an eEF-1alpha Peptide at Threonine 431.

K. Kielbassa, H.-J. Müller, H. E. Meyer, F. Marks, and M. Gschwendt (1995)
J. Biol. Chem. 270, 6156-6162
 |  Abstract »  |  Full Text »  |  PDF »

Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation.

S. Kiley and P. Parker (1995)
J. Cell Sci. 108, 1003-1016
 |  Abstract »  |  PDF »

Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control.

H Kobori, T Toda, H Yaguchi, M Toya, M Yanagida, and M Osumi (1994)
J. Cell Sci. 107, 1131-1136
 |  Abstract »  |  PDF »

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase..

J T Bruder, G Heidecker, and U R Rapp (1992)
Genes & Dev. 6, 545-556
 |  Abstract »  |  PDF »

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

A Bellacosa, Testa JR, S. Staal, and P. Tsichlis (1991)
Science 254, 274-277
 |  Abstract »  |  PDF »

Autophosphorylation of protein kinase C at three separated regions of its primary sequence.

A. Flint, R. Paladini, and D. Koshland Jr (1990)
Science 249, 408-411
 |  Abstract »  |  PDF »

Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans.

Y Tabuse, K Nishiwaki, and J Miwa (1989)
Science 243, 1713-1716
 |  Abstract »  |  PDF »

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.

Y. Hannun and R. Bell (1989)
Science 243, 500-507
 |  Abstract »  |  PDF »

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

S. Hanks, A. Quinn, and T Hunter (1988)
Science 241, 42-52
 |  Abstract »  |  PDF »

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP..

M Z Gilman (1988)
Genes & Dev. 2, 394-402
 |  Abstract »  |  PDF »

Structural and functional roles of glycosyl-phosphatidylinositol in membranes.

M. Low and A. Saltiel (1988)
Science 239, 268-275
 |  Abstract »  |  PDF »

The Family of Protein Kinase C: Its Molecular Heterogeneity and Differential Expression.

U. Kikkawa, K. Ogita, M.S. Shearman, K. Ase, K. Sekiguchi, Z. Naor, A. Kishimoto, Y. Nishizuka, N. Saito, C. Tanaka, et al. (1988)
Cold Spring Harb Symp Quant Biol 53, 97-102
 |  Abstract »  |  PDF »

Protein Kinase C Regulation by Sphingosine/Lysosphingolipids.

R.M. Bell, C.R. Loomis, and Y.A. Hannun (1988)
Cold Spring Harb Symp Quant Biol 53, 103-110
 |  Abstract »  |  PDF »

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.

C House and B. Kemp (1987)
Science 238, 1726-1728
 |  Abstract »  |  PDF »

The raf oncogene is associated with a radiation-resistant human laryngeal cancer.

U Kasid, A Pfeifer, R. Weichselbaum, A Dritschilo, and G. Mark (1987)
Science 237, 1039-1041
 |  Abstract »  |  PDF »

Expression and properties of two types of protein kinase C: alternative splicing from a single gene.

Y Ono, U Kikkawa, K Ogita, T Fujii, T Kurokawa, Y Asaoka, K Sekiguchi, K Ase, K Igarashi, and Y Nishizuka (1987)
Science 236, 1116-1120
 |  Abstract »  |  PDF »

Calcium Coordination and the Calmodulin Fold: Divergent versus Convergent Evolution.

R.H. Kretsinger (1987)
Cold Spring Harb Symp Quant Biol 52, 499-510
 |  Abstract »  |  PDF »

The complete primary structure of protein kinase C--the major phorbol ester receptor.

P. Parker, L Coussens, N Totty, L Rhee, S Young, E Chen, S Stabel, M. Waterfield, and A Ullrich (1986)
Science 233, 853-859
 |  Abstract »  |  PDF »

Protein Kinases in Cellular Signal Transduction: Tyrosine Kinase Growth Factor Receptors and Protein Kinase C.

A. Ullrich, H. Riedel, Y. Yarden, L. Coussens, A. Gray, T. Dull, J. Schlessinger, M.D. Waterfield, and P.J. Parker (1986)
Cold Spring Harb Symp Quant Biol 51, 713-724
 |  Abstract »  |  PDF »

To Advertise   |   Find Products