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Science 15 August 1986:
Vol. 233. no. 4765, pp. 770 - 774
DOI: 10.1126/science.3016895
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Articles

Science, Vol 233, Issue 4765, 770-774
Copyright © 1986 by American Association for the Advancement of Science

articles

Distinct pathways of viral spread in the host determined by reovirus S1 gene segment

KL Tyler, DA McPhee, and BN Fields

The genetic and molecular mechanisms that determine the capacity of a virus to utilize distinct pathways of spread in an infected host were examined by using reoviruses. Both reovirus type 1 and reovirus type 3 spread to the spinal cord following inoculation into the hindlimb or forelimb footpad of newborn mice. For type 3 this spread is through nerves and occurs via the microtubule-associated system of fast axonal transport. By contrast, type 1 spreads to the spinal cord through the bloodstream. With the use of reassortant viruses containing various combinations of double-stranded RNA segments (genes) derived from type 1 and type 3, the viral S1 double-stranded RNA segment was shown to be responsible for determining the capacity of reoviruses to spread to the central nervous system through these distinct pathways.


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