Related Content
Search Google Scholar for:
|
|
Science 1 August 1986: Vol. 233. no. 4763, pp. 545 - 548 DOI: 10.1126/science.2425435
|
|
Articles
Science, Vol 233, Issue 4763, 545-548
Copyright © 1986 by American Association for the Advancement of Science
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor
JA Abraham,
A Mergia,
JL Whang,
A Tumolo,
J Friedman,
KA Hjerrild,
D Gospodarowicz,
and
JC Fiddes
Basic and acidic fibroblast growth factors (FGF's) are potent mitogens for capillary endothelial cells in vitro, stimulate angiogenesis in vivo, and may participate in tissue repair. An oligonucleotide probe for bovine basic FGF was designed from the nucleotide sequence of the amino-terminal exon of bovine acidic FGF, taking into account the 55 percent amino acid sequence homology between the two factors. With this oligonucleotide probe, a full length complementary DNA for basic FGF was isolated from bovine pituitary. Basic FGF in bovine hypothalamus was shown to be encoded by a single 5.0-kilobase messenger RNA; in a human hepatoma cell line, both 4.6- and 2.2-kilobase basic FGF messenger RNA's were present. Both growth factors seem to be synthesized with short amino-terminal extensions that are not found on the isolated forms for which the amino acid sequences have been determined. Neither basic nor acidic FGF has a classic signal peptide.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Differential roles of PDGFR-{alpha} and PDGFR-{beta} in angiogenesis and vessel stability.
- J. Zhang, R. Cao, Y. Zhang, T. Jia, Y. Cao, and E. Wahlberg (2009)
FASEB J
23, 153-163
| Abstract »
| Full Text »
| PDF »
- Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.
- P. Zhu, R. Hata, F. Cao, F. Gu, Y. Hanakawa, K. Hashimoto, and M. Sakanaka (2008)
FASEB J
22, 3866-3877
| Abstract »
| Full Text »
| PDF »
- Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats..
- M. Nakae, H. Kamiya, K. Naruse, N. Horio, Y. Ito, R. Mizubayashi, Y. Hamada, E. Nakashima, N. Akiyama, Y. Kobayashi, et al. (2006)
Diabetes
55, 1470-1477
| Abstract »
| Full Text »
| PDF »
- Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia.
- T. Funasaka, T. Yanagawa, V. Hogan, and A. Raz (2005)
FASEB J
19, 1422-1430
| Abstract »
| Full Text »
| PDF »
- Altered Gene Expression of Angiogenic Factors Induced by Calcium-Mediated Dissociation of Retinal Pigment Epithelial Cells.
- X.-F. Wang, J. Z. Cui, S. S. Prasad, and J. A. Matsubara (2005)
Invest. Ophthalmol. Vis. Sci.
46, 1508-1515
| Abstract »
| Full Text »
| PDF »
- Vascular Endothelial Growth Factor: Basic Science and Clinical Progress.
- N. Ferrara (2004)
Endocr. Rev.
25, 581-611
| Abstract »
| Full Text »
| PDF »
- The Neuropeptide Secretoneurin Acts as a Direct Angiogenic Cytokine In Vitro and In Vivo.
- R. Kirchmair, R. Gander, M. Egger, A. Hanley, M. Silver, A. Ritsch, T. Murayama, N. Kaneider, W. Sturm, M. Kearny, et al. (2004)
Circulation
109, 777-783
| Abstract »
| Full Text »
| PDF »
- Complementary Deoxyribonucleic Acid Cloning of Spermatogonial Stem Cell Renewal Factor.
- T. Miura, T. Ohta, C. I. Miura, and K. Yamauchi (2003)
Endocrinology
144, 5504-5510
| Abstract »
| Full Text »
| PDF »
- Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts.
- J. Liu, C. B. Rich, J. A. Buczek-Thomas, M. A. Nugent, M. P. Panchenko, and J. A. Foster (2003)
Am J Physiol Lung Cell Mol Physiol
285, L1106-L1115
| Abstract »
| Full Text »
| PDF »
- Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-Induced Hepatic Injury and Fibrogenesis.
- C. Yu, F. Wang, C. Jin, X. Huang, D. L. Miller, C. Basilico, and W. L. McKeehan (2003)
Am. J. Pathol.
163, 1653-1662
| Abstract »
| Full Text »
| PDF »
- Secretion of FGF-16 Requires an Uncleaved Bipartite Signal Sequence.
- K. Miyakawa and T. Imamura (2003)
J. Biol. Chem.
278, 35718-35724
| Abstract »
| Full Text »
| PDF »
- Factors Regulating Arteriogenesis.
- W. Schaper and D. Scholz (2003)
Arterioscler Thromb Vasc Biol
23, 1143-1151
| Abstract »
| Full Text »
| PDF »
- Involvement of the Fibroblast Growth Factor System in Adaptive and Chemokine-Induced Arteriogenesis.
- E. Deindl, I. E. Hoefer, B. Fernandez, M. Barancik, M. Heil, M. Strniskova, and W. Schaper (2003)
Circ. Res.
92, 561-568
| Abstract »
| Full Text »
| PDF »
- Cellular and Molecular Deviations in Bovine In Vitro-Produced Embryos Are Related to the Large Offspring Syndrome.
- G. Lazzari, C. Wrenzycki, D. Herrmann, R. Duchi, T. Kruip, H. Niemann, and C. Galli (2002)
Biol Reprod
67, 767-775
| Abstract »
| Full Text »
| PDF »
- Plasma Membrane Disruption in Orthodontic Tooth Movement in Rats.
- M.F. Orellana, A.K. Smith, J.L. Waller, E. DeLeon Jr., and J.L. Borke (2002)
Journal of Dental Research
81, 43-47
| Abstract »
| Full Text »
| PDF »
- Differential regulation of the fibroblast growth factor (FGF) family by {alpha}2-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis.
- I. R. Asplin, S. M. Wu, S. Mathew, G. Bhattacharjee, and S. V. Pizzo (2001)
Blood
97, 3450-3457
| Abstract »
| Full Text »
| PDF »
- Basic Fibroblast Growth Factor and Ultraviolet B Transform Melanocytes in Human Skin.
- C. Berking, R. Takemoto, K. Satyamoorthy, R. Elenitsas, and M. Herlyn (2001)
Am. J. Pathol.
158, 943-953
| Abstract »
| Full Text »
| PDF »
- VASCULAR ENDOTHELIAL GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR IN CHILDREN WITH CYANOTIC CONGENITAL HEART DISEASE.
- S. L. Starnes, B. W. Duncan, J. M. Kneebone, G. L. Rosenthal, T. K. Jones, R. G. Grifka, F. Cecchin, D. J. Owens, C. Fearneyhough, and F. M. Lupinetti (2000)
J. Thorac. Cardiovasc. Surg.
119, 534-539
| Abstract »
| Full Text »
| PDF »
- Angiogenic growth factors: potential new treatment for acute myocardial infarction?.
- L. M Goncalves (2000)
Cardiovasc Res
45, 294-302
| Abstract »
| Full Text »
| PDF »
- Release of bFGF, an Endothelial Cell Survival Factor, by Osmotic Shock.
- M. E. Hartnett, C. M. Garcia, and P. A. D’Amore (1999)
Invest. Ophthalmol. Vis. Sci.
40, 2945-2951
| Abstract »
| Full Text »
| PDF »
- Processing, Secretion, and Anti-HIV-1 Activity of IL-16 With or Without a Signal Peptide in CD4+ T Cells.
- P. Zhou, K. Devadas, D. Tewari, A. Jegorow, and A. L. Notkins (1999)
J. Immunol.
163, 906-912
| Abstract »
| Full Text »
| PDF »
- Nuclear Activities of Basic Fibroblast Growth Factor: Potentiation of Low-Serum Growth Mediated by Natural or Chimeric Nuclear Localization Signals.
- M. Arese, Y. Chen, R. Z. Florkiewicz, A. Gualandris, B. Shen, and D. B. Rifkin (1999)
Mol. Biol. Cell
10, 1429-1444
| Abstract »
| Full Text »
- Repression of Human Fibroblast Growth Factor 2 by a Novel Transcription Factor.
- T. Ueba, B. Kaspar, X. Zhao, and F. H. Gage (1999)
J. Biol. Chem.
274, 10382-10387
| Abstract »
| Full Text »
| PDF »
- Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization.
- H. Ozaki, N. Okamoto, S. Ortega, M. Chang, K. Ozaki, S. Sadda, M. A. Vinores, N. Derevjanik, D. J. Zack, C. Basilico, et al. (1998)
Am. J. Pathol.
153, 757-765
| Abstract »
| Full Text »
| PDF »
- Estrogen Stimulates Delayed Mitogen-Activated Protein Kinase Activity in Human Endothelial Cells via an Autocrine Loop That Involves Basic Fibroblast Growth Factor.
- S. Kim-Schulze, W. L. Lowe Jr, and H. W. Schnaper (1998)
Circulation
98, 413-421
| Abstract »
| Full Text »
| PDF »
- Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis.
- G. Seghezzi, S. Patel, C. J. Ren, A. Gualandris, G. Pintucci, E. S. Robbins, R. L. Shapiro, A. C. Galloway, D. B. Rifkin, and P. Mignatti (1998)
J. Cell Biol.
141, 1659-1673
| Abstract »
| Full Text »
| PDF »
- Mitogenic Effect of Angiotensin II on Rat Carotid Arteries and Type II or III Mesenteric Microvessels but Not Type I Mesenteric Microvessels Is Mediated by Endogenous Basic Fibroblast Growth Factor.
- E. J. Su, D. M. Lombardi, J. Wiener, M. J. A. P. Daemen, M. A. Reidy, and S. M. Schwartz (1998)
Circ. Res.
82, 321-327
| Abstract »
| Full Text »
| PDF »
- Macrophage/Microglia Regulation of Astrocytic Tenascin: Synergistic Action of Transforming Growth Factor-beta and Basic Fibroblast Growth Factor.
- G. M. Smith and J. H. Hale (1997)
J. Neurosci.
17, 9624-9633
| Abstract »
| Full Text »
| PDF »
- Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA.
- H. Tabata, M. Silver, and J. M Isner (1997)
Cardiovasc Res
35, 470-479
| Abstract »
| Full Text »
| PDF »
- Nitric Oxide Promotes Proliferation and Plasminogen Activator Production by Coronary Venular Endothelium Through Endogenous bFGF.
- M. Ziche, A. Parenti, F. Ledda, P. Dell'Era, H. J. Granger, C. A. Maggi, and M. Presta (1997)
Circ. Res.
80, 845-852
| Abstract »
| Full Text »
- Vascular Smooth Muscle Cell Cytotoxicity and Sustained Inhibition of Neointimal Formation by Fibroblast Growth Factor 2–Saporin Fusion Protein.
- A. Farb, S. J. Lee, D. H. Min, Z. Parandoosh, J. Cook, J. McDonald, G. F. Pierce, and R. Virmani (1997)
Circ. Res.
80, 542-550
| Abstract »
| Full Text »
- Pituitary Cytokine and Growth Factor Expression and Action.
- D. Ray and S. Melmed (1997)
Endocr. Rev.
18, 206-228
| Abstract »
| Full Text »
- Endogenous FGF-2 Is Important for Cholinergic Sprouting in the Denervated Hippocampus.
- A. M. Fagan, S. T. Suhr, C. A. Lucidi-Phillipi, D. A. Peterson, D. M. Holtzman, and F. H. Gage (1997)
J. Neurosci.
17, 2499-2511
| Abstract »
| Full Text »
| PDF »
- A cDNA Encoding Fish Fibroblast Growth Factor-2, Which Lacks Alternative Translation Initiation.
- J.-i. Hata, J. Takeo, C. Segawa, and S. Yamashita (1997)
J. Biol. Chem.
272, 7285-7289
| Abstract »
| Full Text »
| PDF »
- Biological Roles of Fibroblast Growth Factor-2.
- A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin (1997)
Endocr. Rev.
18, 26-45
| Abstract »
| Full Text »
- Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens.
- C. Stolen, M. Jackson, and A. Griep (1997)
Development
124, 4009-4017
| Abstract »
| PDF »
- Oncostatin M induces basic fibroblast growth factor expression in endothelial cells and promotes endothelial cell proliferation, migration and spindle morphology.
- E. Wijelath, B Carlsen, T Cole, J Chen, S Kothari, and W. Hammond (1997)
J. Cell Sci.
110, 871-879
| Abstract »
| PDF »
- Integrin Regulation by Endogenous Expression of 18-kDa Fibroblast Growth Factor-2.
- S. Klein, A. Bikfalvi, T. M. Birkenmeier, F. G. Giancotti, and D. B. Rifkin (1996)
J. Biol. Chem.
271, 22583-22590
| Abstract »
| Full Text »
| PDF »
- Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.
- A Vogel, C Rodriguez, and J. Izpisua-Belmonte (1996)
Development
122, 1737-1750
| Abstract »
| PDF »
- Induction of DNA Synthesis by a Single Transient Mechanical Stimulus of Human Vascular Smooth Muscle Cells : Role of Fibroblast Growth Factor–2.
- G. C. Cheng, P. Libby, A. J. Grodzinsky, and R. T. Lee (1996)
Circulation
93, 99-105
| Abstract »
| Full Text »
- Contraction-Induced Cell Wounding and Release of Fibroblast Growth Factor in Heart.
- M. S. F. Clarke, R. W. Caldwell, H. Chiao, K. Miyake, and P. L. McNeil (1995)
Circ. Res.
76, 927-934
| Abstract »
| Full Text »
- Heparan sulfate proteoglycans as transducers of FGF-2 signalling.
- N Quarto and F Amalric (1994)
J. Cell Sci.
107, 3201-3212
| Abstract »
| PDF »
- Generation of cohesive ends on PCR products by UDG-mediated excision of dU, and application for cloning into restriction digest-linearized vectors..
- C Smith, P J Day, and M R Walker (1993)
Genome Res.
2, 328-332
| Abstract »
| PDF »
- Basic fibroblast growth factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes.
- L Sherman, K. Stocker, R Morrison, and G Ciment (1993)
Development
118, 1313-1326
| Abstract »
| PDF »
- Characterization of the nuclear translocation of acidic fibroblast growth factor.
- Y Cao, M Ekstrom, and R. Pettersson (1993)
J. Cell Sci.
104, 77-87
| Abstract »
| PDF »
- Human retinal pigment epithelial cells from different donors continuously produce a vascular endothelial cell-stimulating factor into serum-free medium.
- Q. Yang, R. Smets, A Neetens, and D Vanden Berghe (1993)
J. Cell Sci.
104, 211-218
| Abstract »
| PDF »
- Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development.
- R. Friesel and S. A. Brown (1992)
Development
116, 1051-1058
| Abstract »
| PDF »
- BHK-21-derived cell lines that produce basic fibroblast growth factor, but not parental BHK-21 cells, initiate neuronal differentiation of neural crest progenitors.
- G Brill, N Vaisman, G Neufeld, and C Kalcheim (1992)
Development
115, 1059-1069
| Abstract »
| PDF »
- Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.
- Y. Li, P. Milner, A. Chauhan, M. Watson, R. Hoffman, C. Kodner, J Milbrandt, and T. Deuel (1990)
Science
250, 1690-1694
| Abstract »
| PDF »
- Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence.
- T Imamura, K Engleka, X Zhan, Y Tokita, R Forough, D Roeder, A Jackson, J. Maier, T Hla, and T Maciag (1990)
Science
249, 1567-1570
| Abstract »
| PDF »
- Vascular permeability factor, an endothelial cell mitogen related to PDGF.
- P. Keck, S. Hauser, G Krivi, K Sanzo, T Warren, J Feder, and D. Connolly (1989)
Science
246, 1309-1312
| Abstract »
| PDF »
- Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).
- L. Lin, D Mismer, J. Lile, L. Armes, E. Butler 3rd, J. Vannice, and F Collins (1989)
Science
246, 1023-1025
| Abstract »
| PDF »
- Burn Wound Closure With Cultured Autologous Keratinocytes and Fibroblasts Attached to a Collagen-Glycosaminoglycan Substrate.
- J. F. Hansbrough, S. T. Boyce, M. L. Cooper, and T. J. Foreman (1989)
JAMA
262, 2125-2130
| Abstract »
| PDF »
- Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
- P. Finch, J. Rubin, T Miki, D Ron, and S. Aaronson (1989)
Science
245, 752-755
| Abstract »
| PDF »
- AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
- B Ensoli, S Nakamura, S. Salahuddin, P Biberfeld, L Larsson, B Beaver, F Wong-Staal, and R. Gallo (1989)
Science
243, 223-226
| Abstract »
| PDF »
- The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.
- D Kimelman, J. Abraham, T Haaparanta, T. Palisi, and M. Kirschner (1988)
Science
242, 1053-1056
| Abstract »
| PDF »
- Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells.
- S Nakamura, S. Salahuddin, P Biberfeld, B Ensoli, P. Markham, F Wong-Staal, and R. Gallo (1988)
Science
242, 426-430
| Abstract »
| PDF »
- Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.
- D. Rappolee, C. Brenner, R Schultz, D Mark, and Z Werb (1988)
Science
241, 1823-1825
| Abstract »
| PDF »
- Site-directed neovessel formation in vivo.
- J. Thompson, K. Anderson, J. DiPietro, J. Zwiebel, M Zametta, W. Anderson, and T Maciag (1988)
Science
241, 1349-1352
| Abstract »
| PDF »
- Extracellular Modulating Factors and the Control of Intraocular Neovascularization: An Overview.
- B. M. Glaser (1988)
Arch Ophthalmol
106, 603-607
| Abstract »
| PDF »
- Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.
- H. Weiner, L. Weiner, and J. Swain (1987)
Science
237, 280-282
| Abstract »
| PDF »
- Angiogenic factors.
- J Folkman and M Klagsbrun (1987)
Science
235, 442-447
| Abstract »
| PDF »
- Human Basic Fibroblast Growth Factor: Nucleotide Sequence, Genomic Organization, and Expression in Mammalian Cells.
- J.A. Abraham, J.L. Whang, A. Tumolo, A. Mergia, and J.C. Fiddes (1986)
Cold Spring Harb Symp Quant Biol
51, 657-668
| Abstract »
| PDF »
- Extensive Repertoire of Membrane-bound and Soluble Dendritic Cell-specific ICAM-3-grabbing Nonintegrin 1 (DC-SIGN1) and DC-SIGN2 Isoforms. INTER-INDIVIDUAL VARIATION IN EXPRESSION OF DC-SIGN TRANSCRIPTS.
- S. Mummidi, G. Catano, L. Lam, A. Hoefle, V. Telles, K. Begum, F. Jimenez, S. S. Ahuja, and S. K. Ahuja (2001)
J. Biol. Chem.
276, 33196-33212
| Abstract »
| Full Text »
| PDF »
|
|