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Science 25 July 1986:
Vol. 233. no. 4762, pp. 444 - 446
DOI: 10.1126/science.3726538
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Articles

Science, Vol 233, Issue 4762, 444-446
Copyright © 1986 by American Association for the Advancement of Science

articles

Morphological identification of serotonin-accumulating neurons in the living retina

DI Vaney

Neurons that accumulate the transmitter serotonin have been identified in the living retina by being labeled with 5,7-dihydroxytryptamine (5,7-HT), an autofluorescent serotonin analog. Iontophoretic injection of Lucifer yellow into the labeled cells under microscopic control revealed that the serotonin-accumulating neurons in rabbit retina constitute two morphological types of amacrine cells, termed S1 and S2, whose distal dendrites are stratified at the inner margin of the inner plexiform layer. The dendritic overlap of the S1 type is extraordinarily large: each point on the retina is covered by the fields of 550 to 900 S1 amacrines, and 6 to 8 meters of their dendrites are packed into each square millimeter of retina. Such a pervasive neuropil may provide an effective substrate for diffuse transmitter release, as proposed for serotonergic fibers elsewhere in the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Local Edge Detectors: A Substrate for Fine Spatial Vision at Low Temporal Frequencies in Rabbit Retina.
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Temporal Modulation of Scotopic Visual Signals by A17 Amacrine Cells in Mammalian Retina In Vivo.
C.-J. Dong and W. A. Hare (2003)
J Neurophysiol 89, 2159-2166
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Confocal Analysis of Reciprocal Feedback at Rod Bipolar Terminals in the Rabbit Retina.
J. Zhang, W. Li, E. B. Trexler, and S. C. Massey (2002)
J. Neurosci. 22, 10871-10882
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Glutamate Receptors in the Rod Pathway of the Mammalian Retina.
K. K. Ghosh, S. Haverkamp, and H. Wassle (2001)
J. Neurosci. 21, 8636-8647
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Dopamine-accumulating retinal neurons revealed by in vitro fluorescence display a unique morphology.
D. Dacey (1988)
Science 240, 1196-1198
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